Jason Derks
@jasonderks.bsky.social
Increasing throughput of proteomics @parallelsq.bsky.social
Reposted by Jason Derks
A bit dense, but the important message is dead simple:
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
How to design 1000-plex mass tags using the differential mass defect
Multiplexing samples in mass spectrometry-based proteomics has long been accomplished by isotopologues of small molecules. These chemically-identical "mass tags" conjugate to peptides to encode sample...
www.biorxiv.org
October 24, 2025 at 2:08 PM
A bit dense, but the important message is dead simple:
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
We got to cite the E = mc² paper!
Kidding :)
The important part is that combinations of isotopes unlock 100-1000x gains in protein measurement speed.
Here's how: www.biorxiv.org/content/10.1...
#TeamMassSpec #Proteomics 🧪
Reposted by Jason Derks
The hits keep on coming from @parallelsq.bsky.social! Today we released an exciting use-case for plexDIA in single cell analysis of #alzheimer's disease, characterizing dysregulation of the 20S proteasome. #TeamMassSpec #Proteomics
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Ubiquitin-Proteasome System Dysregulation in Alzheimer's Disease Impacts Protein Abundance
Alzheimer's disease (AD) is a relentlessly progressive, fatal neurodegenerative disorder associated with widespread aberrant proteomic changes. The full extent of protein dysfunctions in AD and their ...
www.biorxiv.org
May 29, 2025 at 5:10 PM
The hits keep on coming from @parallelsq.bsky.social! Today we released an exciting use-case for plexDIA in single cell analysis of #alzheimer's disease, characterizing dysregulation of the 20S proteasome. #TeamMassSpec #Proteomics
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Members of PTI have developed mass tags which improve spectral quality and enable 9-plexDIA in a project lead by @harrisons.bsky.social
🧪 Transforming biomedical discovery needs proteomics that is specific and accurate, but also faster and cheaper
@parallelsq.bsky.social is proud to introduce 9-plex PSMtags: a new mass tag that improves sequencing and increases throughput in sensitive proteomics 👇
www.biorxiv.org/content/10.1...
@parallelsq.bsky.social is proud to introduce 9-plex PSMtags: a new mass tag that improves sequencing and increases throughput in sensitive proteomics 👇
www.biorxiv.org/content/10.1...
www.biorxiv.org
May 28, 2025 at 12:47 PM
Members of PTI have developed mass tags which improve spectral quality and enable 9-plexDIA in a project lead by @harrisons.bsky.social
We are excited to introduce ‘time’ as a new domain for proteomics multiplexing!
It enables:
-Label-free multiplexing
-Combinatorial multiplexing with plexDIA
Using combined 9-plexDIA and 3-timePlex we demonstrate 27-plex DIA 🚀
It enables:
-Label-free multiplexing
-Combinatorial multiplexing with plexDIA
Using combined 9-plexDIA and 3-timePlex we demonstrate 27-plex DIA 🚀
May 28, 2025 at 10:05 AM
We are excited to introduce ‘time’ as a new domain for proteomics multiplexing!
It enables:
-Label-free multiplexing
-Combinatorial multiplexing with plexDIA
Using combined 9-plexDIA and 3-timePlex we demonstrate 27-plex DIA 🚀
It enables:
-Label-free multiplexing
-Combinatorial multiplexing with plexDIA
Using combined 9-plexDIA and 3-timePlex we demonstrate 27-plex DIA 🚀