Marc Mansour
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marcmansour.bsky.social
Marc Mansour
@marcmansour.bsky.social
210 followers 310 following 3 posts

Professor of Haematology at University College London Cancer Institute and Great Ormond Street Institute of Child Health. Clinician scientist investigating, caring for and developing new therapies for patients with acute leukaemia .. more

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Biology 60%
Public Health 25%
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Reposted by Marc R. Mansour

cijilim.bsky.social
Ci Ji (CJ) Lim @cijilim.bsky.social · 11d
Our paper in Science is out! @souravagrawal.bsky.social, @rlynn.bsky.social, @susvirkar.bsky.social, and the rest of the team show human RPA is a telomerase processivity factor essential for telomere maintenance. This reshapes our thinking about telomerase regulation. www.science.org/doi/10.1126/...
Human RPA is an essential telomerase processivity factor for maintaining telomeres
Telomerase counteracts telomere shortening by repeatedly adding DNA repeats to chromosome ends. We identified the replication protein A (RPA) heterotrimer as a telomerase processivity factor critical ...
www.science.org

Reposted by Marc R. Mansour

nickjonesimmuno.bsky.social
Nick Jones @nickjonesimmuno.bsky.social · 21d
Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine.

www.sciencedirect.com/science/arti...
Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia
T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…
www.sciencedirect.com

marcmansour.bsky.social
Marc Mansour @marcmansour.bsky.social · Sep 13
Bye bye X, hello Bluesky !

Reposted by Marc R. Mansour

arnaudkr.bsky.social
Arnaud Krebs @arnaudkr.bsky.social · Aug 18
This is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇

Reposted by Marc R. Mansour

trowbridgelab.bsky.social
Jennifer Trowbridge @trowbridgelab.bsky.social · Apr 16
Congrats to Kira Young who spearheaded this work & all contributing authors. This was a fun (and long!) collaboration with @marcmansour.bsky.social, @challenlab.bsky.social, @ericpietras.bsky.social, Kelsey Fisher-Wellman, @keisukeito-lab.bsky.social & Steven Chan

marcmansour.bsky.social
Marc Mansour @marcmansour.bsky.social · Jan 9
Thanks Sunniyat - great to be part of the Bluesky community- like a breath of fresh air !

marcmansour.bsky.social
Marc Mansour @marcmansour.bsky.social · Jan 8
This is fantastic mechanistic work Dorien, Ruud and team! Congrats

Reposted by Marc R. Mansour

minimolecule.bsky.social
Sunniyat Rahman @minimolecule.bsky.social · Dec 10
For my new followers! Focal deletions of noncoding regions in cancer genomes can have unexpected consequences. Out now in @bloodjournal.bsky.social, we’ve discovered a novel mechanism of oncogene activation whereby focal deletion of a ‘promoter tether’ leads to aberrant expression of IRX3 in T-ALL.👇