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csbj.org
🔗 STAG-LLM: Predicting TCR-pHLA binding with protein language models and computationally generated 3D structures. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#StructuralBiology #ProteinLanguageModels #Immunotherapy #TCR #HLA #Immunology #AI
STAG-LLM: Predicting TCR-pHLA binding with protein language models and computationally generated 3D structures. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.004
December 5, 2025 at 8:23 PM
aromanel.bsky.social
🚨 Out in NAR @narjournal.bsky.social!

Introducing HapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequences.

📄 Paper: doi.org/10.1093/nar/...
💻 DB: bcglab.cibio.unitn.it/hapscoredb

#Bioinformatics #Genomics #ProteinLanguageModels #CompBio
HapScoreDB: a database of protein language model functional scores for haplotype-resolved protein sequences
Abstract. Deciphering the functional effects of genetic variants, especially those inherited together on the same haplotype, remains a major challenge in h
doi.org
November 25, 2025 at 9:25 AM
arxivlens.bsky.social
Nucleotide context models outperform protein language models for predicting antibody affinity maturation
Araki, T., Fukuyama, J. et al.
Paper
Details
#AntibodyAffinity #ProteinLanguageModels #NucleotideContextModels
June 19, 2025 at 9:00 AM
csbugent.bsky.social
📢 CSB at the International Rhodobacter Symposium 2025! 🌎

PhD students Miguel and Carla took the stage to present their cutting-edge work in #proteinlanguagemodels, #biosensor and #geneticcircuits.

Thanks to Isobionics and WUR for the organization!
May 14, 2025 at 11:45 AM
abio.bsky.social
🧬 Honored to contribute to this research on EXO5's role in cancer! We computationally explore how EXO5 common haplotypes shape DNA repair, protein dynamics, and cancer outcomes. Thanks to an amazing team and to the Pezcoller Foundation.
#CancerResearch #Genomics #ProteinLanguageModels #MD
A common haplotype in the EXO5 gene can impact its protein structure and dynamics and modulate genome stability and cancer progression
Understanding the impact of common germline variants on protein structure, function, and disease progression is crucial in cancer research. This study presents a comprehensive analysis of the EXO5 gen...
www.biorxiv.org
November 23, 2024 at 8:56 PM