Computational and Structural Biotechnology Journal (CSBJ)
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Computational and Structural Biotechnology Journal (CSBJ)
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Computational and Structural Biotechnology Journal (CSBJ) is an online open-access journal and is composed of four specialty sections: • General • Smart Hospital • Nanoscience & Advanced Materials • Quantum Biology & Biophotonics

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🔗 Structural modeling and biochemical characterization of MSMEG_0748, a MoxR ATPase from Mycobacterium smegmatis. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#Mycobacterium #ATPase #AlphaFold #StructuralBiology #Biophysics #Microbiology
Structural modeling and biochemical characterization of MSMEG_0748, a MoxR ATPase from Mycobacterium smegmatis. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.010
December 7, 2025 at 3:59 AM
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🔗 Targeting CAPON to modulate the CAPON–NOS Axis: a computational approach. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#DrugDiscovery #ComputationalBiology #AlzheimersResearch #Neuroscience #ProteinProteinInteractions #VirtualScreening
Targeting CAPON to modulate the CAPON–NOS Axis: a computational approach. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.001
December 7, 2025 at 3:27 AM
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🔗 Understanding the characteristic behaviour of the wild-type and mutant structure of FLT3 protein by computational methods. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#ComputationalBiology #MolecularDynamics #StructuralBiology #Cancer
Understanding the characteristic behaviour of the wild-type and mutant structure of FLT3 protein by computational methods. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.023
December 7, 2025 at 2:36 AM
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🔗 Stoichiometric insights into SARS-CoV-2 spike–ACE2 binding across variants. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#COVID19 #SARSCoV2 #SpikeProtein #StructuralBiology #MolecularDynamics #Virology #Biophysics #ComputationalBiology
Stoichiometric insights into SARS-CoV-2 spike–ACE2 binding across variants. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.07.034
December 6, 2025 at 10:41 PM
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🔗 STAG-LLM: Predicting TCR-pHLA binding with protein language models and computationally generated 3D structures. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#StructuralBiology #ProteinLanguageModels #Immunotherapy #TCR #HLA #Immunology #AI
STAG-LLM: Predicting TCR-pHLA binding with protein language models and computationally generated 3D structures. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.004
December 5, 2025 at 8:23 PM
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🔗 DrugForm-DTA: Towards real-world drug-target binding affinity model. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#DrugDevelopment #DrugDiscovery #Cheminformatics #StructuralBiology #ChemicalBiology #DrugTargetAffinity
DrugForm-DTA: Towards real-world drug-target binding affinity model. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.09.023
December 5, 2025 at 7:46 PM
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🔗 Predicting PROTAC off-target effects via warhead involvement levels in drug–target interactions using graph attention neural networks. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#StructuralBiology #ChemicalBiology #PROTAC #DrugDiscovery
Predicting PROTAC off-target effects via warhead involvement levels in drug–target interactions using graph attention neural networks. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.028
November 30, 2025 at 10:54 PM
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🔗 Metabolic phenotypes: Molecular bridges between health homeostasis and disease imbalance. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#MetabolicPhenotyping #Metabolomics #PrecisionMedicine #BiomarkerDiscovery #TranslationalMedicine
Metabolic phenotypes: Molecular bridges between health homeostasis and disease imbalance. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.057
November 30, 2025 at 9:59 PM
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🔗 Temporal complexity of LVV-hemorphin-7 allosterism at the angiotensin II type 1 receptor assessed using entropy-based approaches. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#StructuralBiology #Biophysics #GPCR #Entropy #Pharmacology
Temporal complexity of LVV-hemorphin-7 allosterism at the angiotensin II type 1 receptor assessed using entropy-based approaches. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.024
November 30, 2025 at 9:19 PM
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🔗 Advancing automated cell type annotation with large language models and single-cell isoform sequencing. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#LargeLanguageModels #Genomics #CellBiology #AlternativeSplicing #LLMs #SystemsBiology
Advancing automated cell type annotation with large language models and single-cell isoform sequencing. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.008
November 21, 2025 at 9:54 PM
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🔗 Cell-type specific single-cell signatures reveal nephrotoxic drug effects. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#Nephrotoxicity #CellBiology #Cheminformatics #AcuteKidneyInjury #DrugDiscovery #SingleCellGenomics #DrugDevelopment
Cell-type specific single-cell signatures reveal nephrotoxic drug effects. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.012
November 21, 2025 at 9:11 PM
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🔗 A statistical-physics approach for codon usage optimisation. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#Genomics #CodonOptimization #SyntheticBiology #GeneticEngineering #SystemsBiology #GeneDesign #MolecularBiology
A statistical-physics approach for codon usage optimisation. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.07.020
November 20, 2025 at 9:05 PM
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🔗 Long-range transcription factor binding sites clustered regions may mediate transcriptional regulation through phase-separation interactions in early human embryo. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚CSBJ: www.csbj.org

#DevelopmentalBiology #Genomics
Long-range transcription factor binding sites clustered regions may mediate transcriptional regulation through phase-separation interactions in early human embryo. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.09.017
November 20, 2025 at 7:43 PM
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🧬 What new possibilities emerge when Large Language Models (LLMs) meet large-scale omics data?

🔗 Large language models and their applications in bioinformatics. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚CSBJ: www.csbj.org

#Omics #ArtificialIntelligence #LLM
Large language models and their applications in bioinformatics. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.09.031
November 20, 2025 at 7:02 PM
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🔗Protein allosteric site identification using machine learning and per amino acid residue reported internal protein nanoenvironment descriptors. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚CSBJ: www.csbj.org

#ComputationalBiology #StructuralBiology #Biophysics
Protein allosteric site identification using machine learning and per amino acid residue reported internal protein nanoenvironment descriptors. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.036
November 20, 2025 at 12:52 AM
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🔗 Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#GPCR #StructuralBiology #MolecularDynamics #Pharmacology #Biophysics
Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.039
November 20, 2025 at 12:00 AM
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🔗 Multiscale molecular modeling of chromatin with MultiMM: From nucleosomes to the whole genome. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#Chromatin #ComputationalBiology #Genomics #MolecularModeling #Biophysics #StructuralBiology
Multiscale molecular modeling of chromatin with MultiMM: From nucleosomes to the whole genome. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.09.025
November 17, 2025 at 7:05 PM
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🔗 Molecular dynamics simulations unveil the aggregation patterns and salting out of polyarginines at zwitterionic POPC bilayers in solutions of various ionic strengths. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚CSBJ: www.csbj.org

#MembraneProtein #Biophysics
Molecular dynamics simulations unveil the aggregation patterns and salting out of polyarginines at zwitterionic POPC bilayers in solutions of various ionic strengths. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.004
November 17, 2025 at 6:04 PM
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🔗 Conformational plasticity links structural instability of NAA10F128I and NAA10F128L mutants to their catalytic deregulation. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#Biophysics #Enzymology #StructuralBiology #Mutations #ProteinFolding
Conformational plasticity links structural instability of NAA10F128I and NAA10F128L mutants to their catalytic deregulation. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.014
November 16, 2025 at 7:48 PM
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🔗 RNA-protein interaction prediction without high-throughput data: An overview and benchmark of in silico tools. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#RNA #ProteinInteraction #Genomics #Proteomics #Bioinformatics
RNA-protein interaction prediction without high-throughput data: An overview and benchmark of in silico tools. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.11.015
November 16, 2025 at 6:54 PM
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🔗Impact of water models on the structure and dynamics of enzyme tunnels. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚CSBJ: www.csbj.org

#ComputationalBiology #MolecularDynamics #Enzymology #StructuralBiology #ProteinEngineering #Biophysics #MolecularSimulation
Impact of water models on the structure and dynamics of enzyme tunnels. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2024.10.051
November 16, 2025 at 2:55 PM
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🔗 Evolutionary and structural bioinformatics identifies GPR89 as a conserved member of the LIMR protein superfamily. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#StructuralBiology #ComputationalBiology #Evolution #ProteinScience #AlphaFold
Evolutionary and structural bioinformatics identifies GPR89 as a conserved member of the LIMR protein superfamily. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.003
November 16, 2025 at 1:47 PM
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🔗 Radiomic clustering using graph network techniques coupled with unbalanced optimal transport. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#Radiomics #MedicalImaging #CancerResearch #PrecisionOncology #Radiogenomics #DigitalHealth
Radiomic clustering using graph network techniques coupled with unbalanced optimal transport. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.066
November 16, 2025 at 11:13 AM
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🔗 In silico investigations of albumin-GLP-1 receptor agonist complexes for diabetes drug delivery applications. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#MolecularDynamics #DiabetesResearch #Biotherapeutics #DrugDelivery #Biophysics
In silico investigations of albumin-GLP-1 receptor agonist complexes for diabetes drug delivery applications. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.007
November 16, 2025 at 10:23 AM
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🔗 Does isovaleric acid play a key role in the interaction between probiotics and antidepressants? A secondary analysis of a randomized clinical trial. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#GutBrainAxis #MentalHealth #Probiotics
Does isovaleric acid play a key role in the interaction between probiotics and antidepressants? A secondary analysis of a randomized clinical trial. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.05.035
November 13, 2025 at 9:18 PM