Awesome work by lead author Lauren Burgeno et al: Dopamine evoked by non-contingent cues increases over cocaine use, producing greater cue reactivity; whereas dopamine evoked by contingent cues decreases over cocaine use, producing escalation of drug consumption. www.nature.com/articles/s41...
Cocaine seeking and consumption are oppositely regulated by mesolimbic dopamine in male rats - Nature Communications
Here authors demonstrate how opposing trajectories of dopamine transmission underlie changes in drug seeking and taking over chronic drug use. Increased dopamine to drug cues elevates craving, whereas...
www.nature.com
November 12, 2025 at 8:32 PM
Awesome work by lead author Lauren Burgeno et al: Dopamine evoked by non-contingent cues increases over cocaine use, producing greater cue reactivity; whereas dopamine evoked by contingent cues decreases over cocaine use, producing escalation of drug consumption. www.nature.com/articles/s41...
Because of Lit's focus on helping you build standard & interoperable components. Lit's reactivity is only for element properties, and only sugar for what you would have written by hand in a class setter.
Choosing something like Signals would mean imposing that choice on non-Lit component users...
Choosing something like Signals would mean imposing that choice on non-Lit component users...
October 24, 2025 at 6:31 PM
Because of Lit's focus on helping you build standard & interoperable components. Lit's reactivity is only for element properties, and only sugar for what you would have written by hand in a class setter.
Choosing something like Signals would mean imposing that choice on non-Lit component users...
Choosing something like Signals would mean imposing that choice on non-Lit component users...
Meditated on non-reactivity this morning and came across this:
Mindfulness gives you time.
Time gives you choices.
Choices, skillfully made, lead to freedom.
-Bhante Henepola Gunaratana
#meditation #selfcare
Mindfulness gives you time.
Time gives you choices.
Choices, skillfully made, lead to freedom.
-Bhante Henepola Gunaratana
#meditation #selfcare
December 15, 2024 at 1:49 PM
Meditated on non-reactivity this morning and came across this:
Mindfulness gives you time.
Time gives you choices.
Choices, skillfully made, lead to freedom.
-Bhante Henepola Gunaratana
#meditation #selfcare
Mindfulness gives you time.
Time gives you choices.
Choices, skillfully made, lead to freedom.
-Bhante Henepola Gunaratana
#meditation #selfcare
1/ We know meditation attenuates the conceptual mind, increases equanimity (non-reactivity), and moves experience into the present moment. But what are the computational mechanisms behind this?
February 26, 2025 at 5:59 AM
1/ We know meditation attenuates the conceptual mind, increases equanimity (non-reactivity), and moves experience into the present moment. But what are the computational mechanisms behind this?
FTD it seems to fit
Seems like he’s between stages 6 and 7. This might be why his handlers are always trying to distract him with vanity projects.
“We’re gonna do ARCH! It’s gonna be for ME!”
More info in ALT and here:
www.mayoclinic.org/diseases-con...
stagesofdementia.org/7-stages-of-...
Seems like he’s between stages 6 and 7. This might be why his handlers are always trying to distract him with vanity projects.
“We’re gonna do ARCH! It’s gonna be for ME!”
More info in ALT and here:
www.mayoclinic.org/diseases-con...
stagesofdementia.org/7-stages-of-...
December 20, 2025 at 4:33 AM
FTD it seems to fit
Seems like he’s between stages 6 and 7. This might be why his handlers are always trying to distract him with vanity projects.
“We’re gonna do ARCH! It’s gonna be for ME!”
More info in ALT and here:
www.mayoclinic.org/diseases-con...
stagesofdementia.org/7-stages-of-...
Seems like he’s between stages 6 and 7. This might be why his handlers are always trying to distract him with vanity projects.
“We’re gonna do ARCH! It’s gonna be for ME!”
More info in ALT and here:
www.mayoclinic.org/diseases-con...
stagesofdementia.org/7-stages-of-...
It's not weird or "weak" to have a reaction when a business, government agency, or other entity treats you like a non-person.
When you have a history of familial (or any other kind of) abuse or neglect, getting that "invalidation" button smashed is hard wired to reactivity.
When you have a history of familial (or any other kind of) abuse or neglect, getting that "invalidation" button smashed is hard wired to reactivity.
April 2, 2024 at 9:38 PM
It's not weird or "weak" to have a reaction when a business, government agency, or other entity treats you like a non-person.
When you have a history of familial (or any other kind of) abuse or neglect, getting that "invalidation" button smashed is hard wired to reactivity.
When you have a history of familial (or any other kind of) abuse or neglect, getting that "invalidation" button smashed is hard wired to reactivity.
Our results provide a quantitative framework for interpreting DMS reactivity patterns in RNA. This enables more sophisticated structure prediction algorithms that consider local sequence context, non-canonical interactions, and three-dimensional features - moving beyond simple base-pair predictions.
November 25, 2024 at 3:51 PM
Our results provide a quantitative framework for interpreting DMS reactivity patterns in RNA. This enables more sophisticated structure prediction algorithms that consider local sequence context, non-canonical interactions, and three-dimensional features - moving beyond simple base-pair predictions.
Anna Poggialini, Serena Di Santo, Pablo Villegas, Andrea Gabrielli, Miguel A. Mu\~noz: Non-normal Dynamics on Non-reciprocal Networks: Reactivity and Effective Dimensionality in Neural Circuits https://arxiv.org/abs/2507.19127 https://arxiv.org/pdf/2507.19127 https://arxiv.org/html/2507.19127
July 28, 2025 at 6:47 AM
Anna Poggialini, Serena Di Santo, Pablo Villegas, Andrea Gabrielli, Miguel A. Mu\~noz: Non-normal Dynamics on Non-reciprocal Networks: Reactivity and Effective Dimensionality in Neural Circuits https://arxiv.org/abs/2507.19127 https://arxiv.org/pdf/2507.19127 https://arxiv.org/html/2507.19127
Identification of the seven critical residues that control ZIKV-DENV cross-reactivity to engineer a non-cross-reactive ZIKV vaccine
Identification of the seven critical residues that control ZIKV-DENV cross-reactivity to engineer a non-cross-reactive ZIKV vaccine
Using the epitope maps of 121 DENV antibodies, Grinyo-Escuer et al. identify seven key residues driving DENV-ZIKV cross-reactivity. They engineer a ZIKV E protein variant, “ZIKVm10,” that minimizes DENV cross-reactivity, reduces ADE risk, and protects against lethal ZIKV challenge in mice, offering a pathway for safer, more targeted ZIKV vaccines.
dlvr.it
August 14, 2025 at 12:36 PM
Identification of the seven critical residues that control ZIKV-DENV cross-reactivity to engineer a non-cross-reactive ZIKV vaccine
1/ On the 2nd day of Pharmacy Advent, here’s today’s med pearl! A common scenario...non-antibiotic sulfonamide drug in pt w/ allergy to sulfa Abx
Cross-reactivity is unlikely between sulfonamide Abxs & sulfonamide non-Abx. Here's a short skeetorial 👇 #medsky #pharmsky #EMsky #HMsky #GPsky #nursesky
Cross-reactivity is unlikely between sulfonamide Abxs & sulfonamide non-Abx. Here's a short skeetorial 👇 #medsky #pharmsky #EMsky #HMsky #GPsky #nursesky
December 2, 2024 at 2:42 PM
4. Non-Reactivity as a Sign of Higher Frequency
When you operate from mind sight, you become non-reactive. This means that you no longer let external events or people trigger emotional responses, because you understand that they are temporary or illusory.
Being non-reactive is a sign of being on a
When you operate from mind sight, you become non-reactive. This means that you no longer let external events or people trigger emotional responses, because you understand that they are temporary or illusory.
Being non-reactive is a sign of being on a
January 8, 2025 at 5:42 PM
4. Non-Reactivity as a Sign of Higher Frequency
When you operate from mind sight, you become non-reactive. This means that you no longer let external events or people trigger emotional responses, because you understand that they are temporary or illusory.
Being non-reactive is a sign of being on a
When you operate from mind sight, you become non-reactive. This means that you no longer let external events or people trigger emotional responses, because you understand that they are temporary or illusory.
Being non-reactive is a sign of being on a
False positives matter in immunology too, plenty of receptors identified and cloned using RNA but shown to be non specific when tested for functional reactivity.
pubmed.ncbi.nlm.nih.gov/34321276/
pubmed.ncbi.nlm.nih.gov/34321276/
June 9, 2025 at 3:32 AM
False positives matter in immunology too, plenty of receptors identified and cloned using RNA but shown to be non specific when tested for functional reactivity.
pubmed.ncbi.nlm.nih.gov/34321276/
pubmed.ncbi.nlm.nih.gov/34321276/
I sat with my anger
until it grew bored
and wandered off.
Sometimes
the best defense
is tea and silence.
#poem #poetry #buddhism #mindfulness #right-effort #non-reactivity
until it grew bored
and wandered off.
Sometimes
the best defense
is tea and silence.
#poem #poetry #buddhism #mindfulness #right-effort #non-reactivity
June 26, 2025 at 1:22 PM
I sat with my anger
until it grew bored
and wandered off.
Sometimes
the best defense
is tea and silence.
#poem #poetry #buddhism #mindfulness #right-effort #non-reactivity
until it grew bored
and wandered off.
Sometimes
the best defense
is tea and silence.
#poem #poetry #buddhism #mindfulness #right-effort #non-reactivity
3/ Results show how deconstruction:
▪️ Increases short temporal scale perception
▪️ Reduces conceptual complexity
▪️ Increases equanimity (non-reactivity) and stillness
▪️ Aids the self-regulation of affective valence
▪️ Increases short temporal scale perception
▪️ Reduces conceptual complexity
▪️ Increases equanimity (non-reactivity) and stillness
▪️ Aids the self-regulation of affective valence
February 26, 2025 at 5:59 AM
3/ Results show how deconstruction:
▪️ Increases short temporal scale perception
▪️ Reduces conceptual complexity
▪️ Increases equanimity (non-reactivity) and stillness
▪️ Aids the self-regulation of affective valence
▪️ Increases short temporal scale perception
▪️ Reduces conceptual complexity
▪️ Increases equanimity (non-reactivity) and stillness
▪️ Aids the self-regulation of affective valence
It's listed as "invited" on the ACS website, but we will be accepting contributed (non-invited) submissions. Please consider sending in an abstract if you work in the broad area of computational reactivity studies!
January 8, 2025 at 2:23 PM
It's listed as "invited" on the ACS website, but we will be accepting contributed (non-invited) submissions. Please consider sending in an abstract if you work in the broad area of computational reactivity studies!
In Baltimore City, MD: Hydra 7 - 1yo, female, unaltered, 28lbs
Please click pic for more information via alt text:
Please click pic for more information via alt text:
August 28, 2025 at 10:04 PM
In Baltimore City, MD: Hydra 7 - 1yo, female, unaltered, 28lbs
Please click pic for more information via alt text:
Please click pic for more information via alt text:
7. I played Tetris Effect recently and I enjoyed how much the devs got to play with shaders and reactivity, and the soundtrack is great. It's like watching a VJ set. Here's the main theme, it's a bit cheesy, but I'm non-ironically into it. Hydelic - Connected (Yours Forever)
Connected (Yours Forever) [In-Game Mix]
Song · Hydelic · 2020
open.spotify.com
October 2, 2024 at 11:22 AM
7. I played Tetris Effect recently and I enjoyed how much the devs got to play with shaders and reactivity, and the soundtrack is great. It's like watching a VJ set. Here's the main theme, it's a bit cheesy, but I'm non-ironically into it. Hydelic - Connected (Yours Forever)
Even when a good person has self-awareness, we can still be mouth breathing dummies, even when trying to be kind. It takes an emotionally available person to check ego, be willing to grow, & have vulnerability coupled to non-reactivity. It's all continuous growth, if you can find it on all sides. =)
February 12, 2025 at 8:10 PM
Even when a good person has self-awareness, we can still be mouth breathing dummies, even when trying to be kind. It takes an emotionally available person to check ego, be willing to grow, & have vulnerability coupled to non-reactivity. It's all continuous growth, if you can find it on all sides. =)
longcovid is not uncommon, not prevented by vaccines, and likelihood of developing it increases with every subsequent acute infection. symptoms can range from annoying to debilitating, and impact people with marginalized identities disproportionately.
prevent infection. wear a mask.
prevent infection. wear a mask.
May 15, 2025 at 10:55 PM
longcovid is not uncommon, not prevented by vaccines, and likelihood of developing it increases with every subsequent acute infection. symptoms can range from annoying to debilitating, and impact people with marginalized identities disproportionately.
prevent infection. wear a mask.
prevent infection. wear a mask.
Crucially, the relief of excited-state antiaromaticity is identified as the key driver behind this enhanced reactivity, as non-triplet-antiaromatic amine-boranes exhibit significantly higher barriers for the same transformation.
September 14, 2025 at 5:50 AM
Crucially, the relief of excited-state antiaromaticity is identified as the key driver behind this enhanced reactivity, as non-triplet-antiaromatic amine-boranes exhibit significantly higher barriers for the same transformation.
jeg prøvede sammme øvelse med ChatGPT-5. Der er godt nok meget jargon. Hvis man allerede har besluttet sig for at ville skære ned for bordsalt, kunne jeg godt forestille mig at man læser det som et "ja".
August 8, 2025 at 8:12 PM
jeg prøvede sammme øvelse med ChatGPT-5. Der er godt nok meget jargon. Hvis man allerede har besluttet sig for at ville skære ned for bordsalt, kunne jeg godt forestille mig at man læser det som et "ja".
From @apoethig.bsky.social, [2]rotaxanes with enhanced reactivity (@jacs.acspublications.org).
These rotaxanes were shown to deprotect faster compared to non-interlocked structures due to conformational preorganisation.
🔗 CSD Entry XAJJEC: dx.doi.org/10.5517/ccdc...
#FeaturedStructureFriday
These rotaxanes were shown to deprotect faster compared to non-interlocked structures due to conformational preorganisation.
🔗 CSD Entry XAJJEC: dx.doi.org/10.5517/ccdc...
#FeaturedStructureFriday
July 25, 2025 at 3:35 PM
From @apoethig.bsky.social, [2]rotaxanes with enhanced reactivity (@jacs.acspublications.org).
These rotaxanes were shown to deprotect faster compared to non-interlocked structures due to conformational preorganisation.
🔗 CSD Entry XAJJEC: dx.doi.org/10.5517/ccdc...
#FeaturedStructureFriday
These rotaxanes were shown to deprotect faster compared to non-interlocked structures due to conformational preorganisation.
🔗 CSD Entry XAJJEC: dx.doi.org/10.5517/ccdc...
#FeaturedStructureFriday
I’ve got a few #allergy ones that I’ve created: PEN-FAST score, no cross-reactivity bw sulfa abx and non-sulfa abx, GI intolerance is not an allergy. All have citations.
June 1, 2025 at 6:31 PM
I’ve got a few #allergy ones that I’ve created: PEN-FAST score, no cross-reactivity bw sulfa abx and non-sulfa abx, GI intolerance is not an allergy. All have citations.
Ashes: Afterglow (2021).
I was quite impressed by the first episode but the second is a remarkably ambitious evolution — expanding on the potential for non-linearity, reactivity, sprawling hubs with spokes into intricate maps yet never abandoning the sense of precise authorship and pacing.
I was quite impressed by the first episode but the second is a remarkably ambitious evolution — expanding on the potential for non-linearity, reactivity, sprawling hubs with spokes into intricate maps yet never abandoning the sense of precise authorship and pacing.
August 4, 2023 at 1:05 PM
Ashes: Afterglow (2021).
I was quite impressed by the first episode but the second is a remarkably ambitious evolution — expanding on the potential for non-linearity, reactivity, sprawling hubs with spokes into intricate maps yet never abandoning the sense of precise authorship and pacing.
I was quite impressed by the first episode but the second is a remarkably ambitious evolution — expanding on the potential for non-linearity, reactivity, sprawling hubs with spokes into intricate maps yet never abandoning the sense of precise authorship and pacing.
There's quite a bit of fun reactivity as a MW dwarf with Emmrich, but I cant speak on non-MW dwarf.
July 21, 2025 at 7:30 PM
There's quite a bit of fun reactivity as a MW dwarf with Emmrich, but I cant speak on non-MW dwarf.