#medchem
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pwk2024.bsky.social
A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #cheminformatics #chemsky 🧪
enaminestore.com/catalog/EN30...
February 13, 2026 at 5:48 PM
rscmedchem.rsc.org
Take a look in our latest issue at research from Natalia P. Alza, María Belén Faraoni et al. describing the synthesis and evaluation of lupeol-derived triterpenic azines as potential neuroprotective agents #medchem 🧪

📍Universidad Nacional del Sur
Synthesis and evaluation of lupeol-derived triterpenic azines as potential neuroprotective agents
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the selective loss of dopaminergic neurons and the accumulation of α-synuclein aggregates. Current treatments are…
pubs.rsc.org
February 13, 2026 at 4:03 PM
rscmedchem.rsc.org
🔓Be sure to read this #OpenAccess article from Philip Reigan et al. @cuanschutz.bsky.social investigating the structural requirements of 3,5-substituted oxindoles that determine selective AMPK or GSK3β inhibition #medchem 🧪

Find their full report👇
The structural requirements of 3,5-substituted oxindoles that determine selective AMPK or GSK3β inhibition
AMP-activated protein kinase (AMPK) acts as a central cellular sensor at the interface of metabolic and signaling networks, that supports cell survival in energetically unfavorable environments. Due…
pubs.rsc.org
February 11, 2026 at 3:05 PM
docklahn.bsky.social
🙏 Thanks to our sponsors & partners (2/2):
Ribocure Pharmaceuticals AB · Deutero GmbH · IRLAB Therapeutics AB · ACS Bio & MedChem Au · Svenska Kemisamfundet · Apotekarsocieteten · Royal Society of Chemistry
#GP2A2026 #AccessibleScience
February 11, 2026 at 8:45 AM
degottegilles.bsky.social
🚄 On my way to the SCT 33rd Young Research Fellows Meeting in Marseille ( @univ-amu.fr )

⚗️ Thrilled for three days of #medchem & #chembio !

🥂Excited to meet my colleagues from the @ymcf-sct.bsky.social !
February 11, 2026 at 8:21 AM
knightchem.bsky.social
Our hydrazide catalog keeps growing! Check out our new products. Request a quote for custom bottle sizes. #knightchem #medchem #new
February 10, 2026 at 7:41 PM
docklahn.bsky.social
🙏 Thanks to our sponsors & partners (2/2):
Ribocure Pharmaceuticals AB · Deutero GmbH · IRLAB Therapeutics AB · ACS Bio & MedChem Au · Svenska Kemisamfundet · Apotekarsocieteten · Royal Society of Chemistry
February 10, 2026 at 3:07 PM
docklahn.bsky.social
🙏 Thanks to our sponsors & partners (2/2):
Ribocure Pharmaceuticals AB · Deutero GmbH · IRLAB Therapeutics AB · ACS Bio & MedChem Au · Svenska Kemisamfundet · Apotekarsocieteten · Royal Society of Chemistry
February 9, 2026 at 10:38 AM
rscmedchem.rsc.org
Don't miss research by Yu Zhang, Jun Luo & co. at Nanjing University of Science & Technology in our latest issue using peripheral tailoring of pentacene to develop next-generation organic sonosensitizers for cancer sonodynamic therapy #medchem 🧪

Check it out here🔽
Peripheral tailoring of pentacene: developing next-generation organic sonosensitizers for cancer sonodynamic therapy
Sonodynamic therapy (SDT) is an innovative, non-invasive, and effective method for cancer treatment. However, exploring sonosensitizers with high sonosensitivity and biosafety remains a significant…
pubs.rsc.org
February 9, 2026 at 9:30 AM
fabermdphd.bsky.social
Love this kind of work that connects conformational selectivity of a drug to its target with possibly improved therapeutic properties #medchem

www.nature.com/articles/s41...
GTP release-selective agonists prolong opioid analgesic efficacy - Nature
Mu opioid receptor agonists with a preference for the non-GTP-bound state of the G protein promote GTP release, thereby potentiating antinociceptive effects of drugs such as morphine and fentanyl with...
www.nature.com
February 7, 2026 at 8:15 PM
docklahn.bsky.social
🙏 Thanks to our sponsors & partners (2/2):
Ribocure Pharmaceuticals AB · Deutero GmbH · IRLAB Therapeutics AB · ACS Bio & MedChem Au · Svenska Kemisamfundet · Apotekarsocieteten · Royal Society of Chemistry
February 7, 2026 at 9:26 AM
pwk2024.bsky.social
A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #chemsky 🧪
enaminestore.com/catalog/EN30...
February 6, 2026 at 11:20 PM
docklahn.bsky.social
🙏 Thanks to our sponsors & partners (2/2):
Ribocure Pharmaceuticals AB · Deutero GmbH · IRLAB Therapeutics AB · ACS Bio & MedChem Au · Svenska Kemisamfundet · Apotekarsocieteten · @rsc.org @rscmedchem.rsc.org @rscchembio.rsc.org
#GP2A2026 #ScientificCommunity
February 6, 2026 at 7:43 PM
lanoviadelatomo.bsky.social
¿Qué sabes de #QuímicaMédica?

En nuestro instituto @iqm-csic.bsky.social puedes formarte en este campo. Se abre el plazo este lunes 9 de febrero, ¡ojo!

#MedChem #MedicinalChemistry @csicdivulga.bsky.social
February 6, 2026 at 11:13 AM
rscmedchem.rsc.org
Check out research by Trevor J. Kilpatrick, Jonathan B. Baell et al. from @monashuniversity.bsky.social reporting fluorinated pyrimidine 5-carboxamides as potential tools for MERTK targeted fluorine-18-PET-radioligand development #medchem 🧪

Read in full below👇
Fluorinated pyrimidine 5-carboxamides as potential tools for MERTK targeted fluorine-18-PET-radioligand development
MER tyrosine kinase (MERTK) is highly expressed on the protective and reparative phenotype of microglia, which is in response to neuroregeneration following the neuronal damage induced by multiple…
pubs.rsc.org
February 6, 2026 at 10:02 AM
rscmedchem.rsc.org
🔓Take a look in our latest issue at this #OpenAccess review by Franck Amblard, Raymond Schinazi & co. providing an overview of prodrug strategies in developing antiviral nucleoside analogs #medchem 🧪

📍Emory University
Prodrug strategies in developing antiviral nucleoside analogs
Prodrug strategies are used to enhance the physicochemical and pharmaceutical properties of drug candidates that may not be suitable for specific delivery or are limited by formulation options. A…
pubs.rsc.org
February 3, 2026 at 3:29 PM
rscmedchem.rsc.org
🔓Be sure to read #OpenAccess research, part of our 5th Anniversary collection, from Jean-Louis Reymond et al. @reymondgroup.bsky.social at @unibe.ch in our latest issue diversifying the triquinazine scaffold of a Janus kinase inhibitor #medchem 🧪

Find the full report👇
Diversifying the triquinazine scaffold of a Janus kinase inhibitor
The exploration of novel three-dimensional scaffolds remains essential for expanding chemical space and discovering new bioactive molecules. Here, we describe a robust synthetic strategy that enables…
pubs.rsc.org
February 2, 2026 at 12:02 PM
pwk2024.bsky.social
A most excellent molecule with which to conclude the week #SynChem #BB #MedChem #DrugDesign #DrugDiscovery #cheminformatics #chemsky 🧪
enaminestore.com/catalog/EN30...
January 30, 2026 at 10:48 PM
rscmedchem.rsc.org
Don't miss this review in our latest issue by Natalie Holmberg-Douglas & co. @bristolmyerssquibb.bsky.social looking at the recent advances in glutarimide chemistry for cereblon-mediated targeted protein degradation #medchem 🧪

Check it out in full here🔽
Recent advances in glutarimide chemistry for cereblon-mediated targeted protein degradation: developments in synthesis and diversification
The field of targeted protein degradation has garnered significant attention over the past two decades, highlighted by the FDA approval of several therapeutics and the entry of numerous drug…
pubs.rsc.org
January 30, 2026 at 2:34 PM
bethanyhalford.bsky.social
Many years ago when I was a graduate student doing medchem, compounds would languish in our freezers after testing. Chemists in Matthew Todd's group are looking to make better use of such molecules. My latest for @cenmag.bsky.social.
#chemsky
cen.acs.org/pharmaceutic...
How to put drug leads forgotten in the freezer back to work
Open science advocates create a guide to sharing medicinal molecule collections
cen.acs.org
January 29, 2026 at 4:59 PM
rscmedchem.rsc.org
📢Our first issue of 2026 is now online!

🔓Check out the #OpenAccess article behind the cover by Naoko Yoshizawa-Sugata, Hisao Masai, Yoko Yamakoshi & co. @ethz.ch reporting new water-soluble cationic porphyrins with enhanced phototoxicity to cancer cell lines #medchem

pubs.rsc.org/en/content/a...
January 28, 2026 at 3:10 PM
natprodreports.rsc.org
📢Our first issue of 2026 is now online!

Check out the review behind the cover by Mark Butler, Robert Capon & co. at the University of Queensland covering natural product-derived compounds in clinical trials & drug approvals from 2014-2024 #natprod #secmet #medchem

pubs.rsc.org/en/content/a...
January 28, 2026 at 3:01 PM
longevitytech.bsky.social
A subtle redesign of drug molecules could unlock multi-target treatments for one of aging’s toughest diseases.

longevity.technology/news/simple-...

#longevity #alzheimers #drugdiscovery #biotech #medchem #multitarget #agingresearch #neurodegeneration #healthspan #clinicalresearch #science
January 26, 2026 at 6:50 PM
gcanudo-barreras.bsky.social
So proud to see our cover of the Journal of Medicinal Chemistry! 🧪🎨

We introduce ViVo, a new framework for temporal modeling designed to maximize data quality and minimize animal usage. 📉🐁
@conchitagimeno.bsky.social
Link: pubs.acs.org/doi/10.1021/...

#Science #MedChem #DrugDevelopment #ViVo
Cover of Journal of Medicinal Chemistry. The artwork illustrates the ViVo temporal modeling framework, showing a blend of advanced statistical data visualizations and biological research elements to represent the reduction of animal usage in drug discovery.
January 26, 2026 at 1:37 PM
pwk2024.bsky.social
I’ve reviewed ‘The European Federation for Medicinal Chemistry and Chemical Biology (EFMC) Best Practice Initiative: Hit to Lead’ ChemMedChem 2025 20 e202400931 DOI: 10.1002/cmdc.202400931 #H2L #MedChem #cheminformatics #chemsky 🧪
fbdd-lit.blogspot.com/2026/01/hit-...
Hit to Lead best practice?
I'm now in Trinidad and I'll share a 180° panorama from Paramin where I walk for exercise. This district in Trinidad's Northern Range is ren...
fbdd-lit.blogspot.com
January 26, 2026 at 9:53 AM