#Uukuniemi
No hei, hei! Mielestäni Uukuniemi (nyk. Parikkala) on ihan eri maata. Iloista hurlumheitä ja hauskaa kylämeisinkiäkin on. Sykkeellä ja otteella. 😁
January 29, 2026 at 11:01 AM
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells

journals.plos.org/plospathogen...
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells
Author summary In host cells, RNA-binding proteins play essential roles in the life cycle of many viruses by influencing how viral RNA is processed, translated, replicated and assembled into virions. ...
journals.plos.org
September 24, 2025 at 1:00 PM
Our new PLOS Pathogens paper with ‪@brennanlab.bsky.social‬ is out! We charted the first protein–RNA interaction map for virus-infected tick cells, revealing 283 RNA-binding proteins reshaped by Uukuniemi virus. Some directly control viral particle output. Full story: doi.org/10.1371/jour...
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells
Author summary In host cells, RNA-binding proteins play essential roles in the life cycle of many viruses by influencing how viral RNA is processed, translated, replicated and assembled into virions. ...
doi.org
August 13, 2025 at 3:59 PM
Thread: How Viruses Hijack Tick RNA Machinery 🧬🕷️

Post 1/5 🧵
We just published the first map of how viruses rewire tick cell RNA machinery! Led by Alexandra Wilson & Wael Kamel!

We Found 283 proteins that change RNA-binding during Uukuniemi virus infection.

📄 Our paper: doi.org/10.1371/jour...
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells
Author summary In host cells, RNA-binding proteins play essential roles in the life cycle of many viruses by influencing how viral RNA is processed, translated, replicated and assembled into virions. ...
doi.org
August 13, 2025 at 12:32 PM
This study systematically identified changes in the RNA-binding activity of 283 proteins in tick cells infected with the bunyavirus Uukuniemi virus (UUKV).
August 11, 2025 at 11:06 PM
Tick cells undergo a profound remodeling of their RNA-binding proteome when infected by Uukuniemi virus, uncovering a critical role for the tick homolog of topoisomerase 3B in viral parti...

🧵 Thread below

Full analysis: https://helixbrief.com/article/d0bbc0ee-19e0-46fa-92e2-a3e8bebef200
August 11, 2025 at 11:06 PM
Paikka, jossa ei ole ennen käyty -teemalla hurautettiin tänään tsekkaamaan #Uukuniemi. Poikkesi odotuksista. Kirkonkylällä oli vain kirkko (toki myös muutama savu). Kyläkeskus Niukkala löytyi 10 kilsan päässä, siellä Uukuniemen kyläkauppa.

Kuvissa Kalasatama, Pyhäjärvi.

#kesäretki2025 ♥️
August 10, 2025 at 6:34 PM
Kaukaisimmat paikat, joissa olen käynyt:

N: Ruka, Suomi
E: Uukuniemi, Suomi
S: Barcelona, Espanja
W: Tukholma, Ruotsi
bsky.app/profile/kius...
Kaukaisimmat paikat, joissa olen käynyt:

N: Tromssa, Norja
E: Joensuu, Suomi
S: Gran Canaria, Espanja
W: Reykjavik, Islanti
Kaukaisimmat paikat, joissa olen käynyt:

N: Tromssa, Norja
E: Soul, Etelä-Korea
S: Maspalomas, Espanja (Kanariansaaret)
W: New York, Yhdysvallat
August 10, 2025 at 9:10 AM
Furthest I've been:

N: Muonio, Finland
E: Uukuniemi, Finland
S: Gran Canaria, Spain
W: Vancouver, Canada

For the future I have decided not to fly to any targer ever. It's been 8 years to my last flight.
Furthest I've been:

N: Tana bru, Norja
E: Pyongyang, Pohjois-Korea
S: Faro, Portugali
W: Lissabon, Portugali

Further distances will hopefully be reached in the future. 😄
Furthest I've been:

N: Kilpisjärvi, Finland
E: Kuusamo, Finland.
S: Cologne, Germany
W: Düsseldorf, Germany

Would love to go more east or south someday.
August 8, 2025 at 7:56 PM
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in #tick cells PLOSPathogens
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in #tick cells
by Alexandra Wilson, Wael Kamel, Kelsey Davies, Zaydah R. De Laurent, Rozeena Arif, Andrew T. Clarke, Lesley Bell-Sakyi, Douglas Lamont, Yana Demyanenko, Marko Noerenberg, Alain Kohl, Shabaz Mohammed, Alfredo Castello, Benjamin Brennan Cellular RNA-binding proteins (RBPs) are pivotal for the viral lifecycle, mediating key host-virus interactions that promote or repress virus infection. While these interactions have been largely studied in the vertebrate host, no comprehensive analyses of protein-RNA interactions occurring in cells of arbovirus vectors, in particular ticks, have been performed to date. Here we systematically identified the responses of the RNA-binding proteome (RBPome) to infection with a prototype bunyavirus (Uukuniemi virus; UUKV) in tick cells and discovered changes in RNA-binding activity for 283 proteins. In an orthogonal approach, we analysed the composition of the viral ribonucleoprotein by immunoprecipitation of UUKV nucleocapsid protein (N) in infected cells. We found many tick RBPs that are regulated by UUKV infection and associate with viral nucleocapsid protein complexes, and we confirmed experimentally that they impact UUKV infection. This includes the tick homolog of topoisomerase 3B (TOP3B), a protein able to manipulate the topology of RNA, which particularly affected viral particle production. Our data thus reveals the first protein-RNA interaction map for infected tick cells.
dlvr.it
August 8, 2025 at 2:24 PM
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in #tick cells PLOSPathogens
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in #tick cells
by Alexandra Wilson, Wael Kamel, Kelsey Davies, Zaydah R. De Laurent, Rozeena Arif, Andrew T. Clarke, Lesley Bell-Sakyi, Douglas Lamont, Yana Demyanenko, Marko Noerenberg, Alain Kohl, Shabaz Mohammed, Alfredo Castello, Benjamin Brennan Cellular RNA-binding proteins (RBPs) are pivotal for the viral lifecycle, mediating key host-virus interactions that promote or repress virus infection. While these interactions have been largely studied in the vertebrate host, no comprehensive analyses of protein-RNA interactions occurring in cells of arbovirus vectors, in particular ticks, have been performed to date. Here we systematically identified the responses of the RNA-binding proteome (RBPome) to infection with a prototype bunyavirus (Uukuniemi virus; UUKV) in tick cells and discovered changes in RNA-binding activity for 283 proteins. In an orthogonal approach, we analysed the composition of the viral ribonucleoprotein by immunoprecipitation of UUKV nucleocapsid protein (N) in infected cells. We found many tick RBPs that are regulated by UUKV infection and associate with viral nucleocapsid protein complexes, and we confirmed experimentally that they impact UUKV infection. This includes the tick homolog of topoisomerase 3B (TOP3B), a protein able to manipulate the topology of RNA, which particularly affected viral particle production. Our data thus reveals the first protein-RNA interaction map for infected tick cells.
dlvr.it
August 7, 2025 at 7:22 AM
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells

journals.plos.org/plospathogen...
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells
Author summary In host cells, RNA-binding proteins play essential roles in the life cycle of many viruses by influencing how viral RNA is processed, translated, replicated and assembled into virions. ...
journals.plos.org
August 5, 2025 at 2:37 PM
March 13, 2025 at 12:02 PM
March 13, 2025 at 11:05 AM
Metropoli uukuniemi. Meet sinne.
March 5, 2025 at 10:22 AM
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cell cultures https://www.biorxiv.org/content/10.1101/2024.09.06.611624v1
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cell cultures https://www.biorxiv.org/content/10.1101/2024.09.06.611624v1
RNA-binding proteins (RBPs) are pivotal for the viral lifecycle, mediating key host-virus interactio
www.biorxiv.org
September 7, 2024 at 5:16 AM
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cell cultures https://www.biorxiv.org/content/10.1101/2024.09.06.611624v1
Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cell cultures https://www.biorxiv.org/content/10.1101/2024.09.06.611624v1
RNA-binding proteins (RBPs) are pivotal for the viral lifecycle, mediating key host-virus interactio
www.biorxiv.org
September 7, 2024 at 5:16 AM