#TriNetX
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danieljdrucker.bsky.social
In adults with a history of seizure disorder in TriNetX, GLP-1 RA initiation was associated with reduced risks of seizure recurrence, hospitalization, and mortality compared with other glucose-lowering therapies onlinelibrary.wiley.com/doi/10.1111/...
Seizure recurrence after GLP‐1 receptor agonist initiation in adults with epilepsy
Objective To examine whether initiation of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) is associated with seizure recurrence and related outcomes in adults with epilepsy and type 2 diabete...
onlinelibrary.wiley.com
November 18, 2025 at 3:53 PM
rheumnow.bsky.social
Postmenopausal women on estrogen hormone therapy (HT) had a modest incr risk (HR 1.33; 1.32-1.35; P < .001). of a new autoimmune Dz over 5-10 yrs (vs those not on HT) TriNetX study of 889,413 HT vs 2,6 mill (not HT) - 6.7% vs 5.3% developed autoimmune dz at 5 yrs. www.medscape.com/viewarticle/...
Modestly Higher Risk for Autoimmune Disease Linked to HT
The observational study could not show a causal effect and should not change existing practice, experts emphasized.
www.medscape.com
November 17, 2025 at 8:01 PM
med-office-j.bsky.social
【備忘】Nov.12

EJPC誌にTriNetXデータベースを用いた研究のデザインにまつわる問題点を指摘するレター [詳細不詳]。「検定力の観点から使用が増えているが、方法論を詳細に検討しないとバイアスのかかった結果になる可能性がある」との記載。

x.gd/Q9NaA
November 13, 2025 at 11:18 PM
utmbspph.bsky.social
H-COR is recruiting for two roles at @utmbhealth.bsky.social:
Healthcare Data Analyst and Research Scientist II. Work with Epic, TriNetX, Medicare. Build cohorts, apply causal methods, publish with cross-campus teams.
Details utmb.us/esq utmb.us/esr
November 13, 2025 at 4:19 PM
12-month or longer melatonin use linked to 90% greater heart failure risk/1 For this study, researchers analyzed medical data from TriNetX for almost 131,000 adults with an average age of about 56 who had been diagnosed with insomnia.

www.medicalnewstoday.com/articles/lon...
Heart failure: Long-term melatonin use linked to higher risk
Long-term use of melatonin supplements for sleep may be linked to a greater risk for heart failure, a recent study suggests.
www.medicalnewstoday.com
November 8, 2025 at 5:49 PM
med-office-j.bsky.social
【CTRCD例の生存をGLP-1RAが改善？/JAHA】Nov 06

国際民間患者DB “TriNetX”内、がん治療関連心機能障害、PSマッチ可能だった4,982例比較——、
・17%がGLP-1RA使用。
・GLP-1RA「使用」で「不使用」に比べ、死亡HRは0.57 [!] [95%CI：
　0.43-0.77]。HF増悪は0.69 [0.56-0.85] 。
・心室頻拍は減少傾向にとどまる。

全文🔗
x.gd/nTgws
November 7, 2025 at 11:53 PM
dslevine.bsky.social
Jeffrey Brown CSO of TriNetX, discusses how real-world data can address common challenges in rare disease research, the hurdles that need to be addressed, and how advances in AI could revolutionize rare disease research. @globalgenes.bsky.social #RARECast

globalgenes.org/raredaily/tr...
Transforming Real-Word Patient Data into Breakthroughs
Jeff Brown, chief scientific officer of TriNetX, discusses how real-world data can address common challenges in rare disease research, the hurdles that need to be addressed, and how advances in AI cou...
globalgenes.org
November 7, 2025 at 5:15 PM
cronaca.bsky.social
Melatonina, un uso prolungato peserebbe sulla salute del cuore

https://www.europesays.com/it/202000/

 Utilizzando un ampio database internazionale (il TriNetX Global Research Network), i ricercatori hanno esaminato cinque anni di cartelle…
Melatonina, un uso prolungato peserebbe sulla salute del cuore - Italia
 Utilizzando un ampio database internazionale (il TriNetX Global Research Network), i ricercatori hanno esaminato cinque anni di cartelle cliniche
www.europesays.com
November 6, 2025 at 12:00 PM
cincykidsallergyim.bsky.social
The newly funded research "Evaluating Longitudinal Impact of Early Peanut Introduction Guidelines on IgE-Mediated PA via TriNetX" is led by the Winslow Lab in collaboration with the Devonshire and Andorf Labs.
nationalpeanutboard.org/news/nationa...

www.cincinnatichildrens.org/research/div...
National Peanut Board Awards Over $450,000 in Food Allergy Research Grants
The National Peanut Board has awarded more than $450,000 in grants to nine organizations.
nationalpeanutboard.org
November 5, 2025 at 6:35 PM
christosargyrop.bsky.social
More TriNetX stuff about covid from our group.

Hint: don't get it

bsky.app/profile/chri...
November 5, 2025 at 5:37 AM
castltrastondrs.bsky.social
#Medsky🧪 #IDsky #immunosky #publichealth A population-based retrospective cohort study using the TriNetX healthcare database, which includes data from over 127 mil patients globally, found that unvaccinated #LongCOVID individuals have an ⏫️ risk of developing new-onset uveitis, esp anterior uveitis.
November 5, 2025 at 5:35 AM
sloanea5.bsky.social
„Patienten, denen länger als ein Jahr lang #Melatonin verordnet wurde, erkrankten in einer Analyse der Datenbank TriNetX fast doppelt so häufig an einer Herzinsuffizienz und mussten mehr als dreimal so häufig deswegen in einer Klinik behandelt werden.”
Langfristige Einnahme von Melatonin könnte dem Herzen schaden – Deutsches Ärzteblatt
www.aerzteblatt.de
November 4, 2025 at 11:20 PM
leanhealth.bsky.social
#FactsareaBitch

TriNetX study, >127 mio patients

unvaccinated Longcovid patients have 2x risk of uveitis development -eye’s middle layer, 1–2 years after infection. Source joii-journal.springeropen.com/articles/10....
Long COVID and the development of new-onset uveitis: a large database study - Journal of Ophthalmic Inflammation and Infection
Purpose To determine the impact of long COVID diagnosis on the risk of developing uveitis among individuals vaccinated and not vaccinated against COVID. Methods We conducted a population-based retrosp...
joii-journal.springeropen.com
November 4, 2025 at 6:13 PM
rheumnow.bsky.social
GLP-1 Receptor Agonists: Impacts Beyond Metabolism?

Across multiple abstracts, investigators have used a large real-world dataset, the TriNetX network, to explore how GLP-1RAs might influence cardiovascular, renal and immune-mediated outcomes in our patients. #ACR25

rheumnow.com/news/glp-1-r...
November 3, 2025 at 4:01 PM
rheumcat.bsky.social
Abs 2689 Armstrong et al

🔎 RWE from the EMR looking at biologic classes and risk of incident PsA

🖇️ Very similar to our TriNetX study published here: pubmed.ncbi.nlm.nih.gov/38251522/

#ACR25
October 29, 2025 at 12:01 AM
rheumcat.bsky.social
Abs 2659 @jamiechiehlo.bsky.social

📊 Data source: TriNetX

Exposure/comparator: SGLT2i vs DPP4i
Outcome: incident SARD

#ACR25
October 28, 2025 at 11:02 PM
rheumcat.bsky.social
Abs 2658 Chen et al

📊 Data source: TriNetX
👨‍👨‍👦 Cohorts: T2DM; obesity

Exposure/comparator: GLP1ra vs non use
Outcome: incident IMID, incident neurodegenerative disorders (Parkinson’s, Alzheimer’s); mortality

#ACR25
October 28, 2025 at 11:02 PM
rheumcat.bsky.social
Abs 2657 Ibis et al

📊 Data source: TriNetX
👨‍👨‍👦 Inclusion: gen pop

Exposure/comparator: GLP1ra vs DPP4i
Outcome: incident RMD within 1 year

#ACR25
October 28, 2025 at 11:02 PM
rheumcat.bsky.social
Sad to miss this session. The session chair(s) carefully put together 3 TriNetX abstracts asking similar questions of GLP1 receptor agonists and SGLT2 inhibitors.

#ACR25
October 28, 2025 at 11:02 PM
rheumcat.bsky.social
Abs 2633 Chen et al

📊 Data source: TriNetX
👨‍👨‍👦 Study pop: AS

🔎 Looked at the safety of TNFi and JAKi through multiple outcomes

👉 MACE, VTE – null for both med classes
💊 JAKi use a/w higher risk of GIB, mortality (HR ~5) (!)

#ACR25
October 28, 2025 at 8:04 PM
rheumcat.bsky.social
Abs 2363 Heydari et al

📊 Data source: TriNetX

❓ Q: in PsA do other biologics have a different risk of MACE and VTE vs TNFi?
We asked a similar question in a paper currently in press!

#ACR25
October 28, 2025 at 4:31 PM
rheumcat.bsky.social
Abs 2087 Afshar et al

📊 Data source: TriNetX

🔎 Interesting premise: is carbamazepine, which acts thru Nav1.7 channels implicated in OA pathogenesis, protective against OA development?

#ACR25
October 28, 2025 at 3:06 PM
rheumcat.bsky.social
Abs 1418 Ajenaghughrure et al

📊 Data source: TriNetX
👨‍👨‍👦 Study pop: AS + NSAID use

Exposure: T2DM
👉 Outcomes: mortality RR 2.03, Afib RR 2.97, HR RR 2.73, CVA 2.29

#ACR25
October 27, 2025 at 4:31 PM
rheumcat.bsky.social
📊 Data source: TriNetX
Exposure/comparator: GLP1ra vs non-use
👨‍👨‍👦 Study pop: PsA, n=4104 exposed matched 1:1 unexposed (PSM)

👉 Outcomes/results:
Mortality RR 0.31 (i.e, GLP1ra use was a/w nearly 70% lower risk of mortality vs non use)

#ACR25
October 27, 2025 at 1:06 PM
rheumcat.bsky.social
Abs 0813 Challener et al (MGH)

📊 Data source: TriNetX
❓ Q: is Tirzepatide, the dual GLP1/GIP agonist, able to reduce MSK pain in obese and overweight people prescribed this medicine?

#ACR25
October 26, 2025 at 8:02 PM