🧠 Developing a Treatment Decision-Making Aid for Major Depressive Disorder Using Functional Brain Measures
📅 Sat 5/17 1:30-3pm
📍 Exhibit Hall, LACC
@apapsychiatric.bsky.social
🧠 Developing a Treatment Decision-Making Aid for Major Depressive Disorder Using Functional Brain Measures
📅 Sat 5/17 1:30-3pm
📍 Exhibit Hall, LACC
@apapsychiatric.bsky.social
New work from @drchristineannd.bsky.social & @brikchen.bsky.social finds that chronic combinatorial administration of ketamine + the 5HT4R agonist prucalopride exerts potential therapeutic effects in multiple 🐭 models of stress
www.nature.com/articles/s41...
He picked one hell of a data model for his first ever poster presentation. It fit in perfectly with all of the talks I went to this week. Moral of the week… people are special, stop averaging 🥲 #SOBP2025
He picked one hell of a data model for his first ever poster presentation. It fit in perfectly with all of the talks I went to this week. Moral of the week… people are special, stop averaging 🥲 #SOBP2025
Several taxa have significant associations with PRS for taxa. Validated across multiple cohorts.
Microbial PRS are associated with remission to sertraline (not surviving multiple comparisons)
Several taxa have significant associations with PRS for taxa. Validated across multiple cohorts.
Microbial PRS are associated with remission to sertraline (not surviving multiple comparisons)
Host genetics affect microbiome composition. Generate polygenic risk scores for heritable taxa.
18k mostly EUR participants from multiple studies. Correlation of PRS with microbiome 16S data.
Host genetics affect microbiome composition. Generate polygenic risk scores for heritable taxa.
18k mostly EUR participants from multiple studies. Correlation of PRS with microbiome 16S data.
Integration of experimental models and early human experiments argued for a role of microbiome in mental health.
Microbiome is a confluence of lots of factors, including numerous environments and host genome — think about hologenomes (host+microbes)
Integration of experimental models and early human experiments argued for a role of microbiome in mental health.
Microbiome is a confluence of lots of factors, including numerous environments and host genome — think about hologenomes (host+microbes)
We contain multitudes, more microbes than cells in body, so microbes have a lot of influence on us.
Microbiome is a function of host genetics and environment, so it's a good candidate for individual differences.
Microbiota-gut-brain axis. Continual crosstalk of host and microbiome
We contain multitudes, more microbes than cells in body, so microbes have a lot of influence on us.
Microbiome is a function of host genetics and environment, so it's a good candidate for individual differences.
Microbiota-gut-brain axis. Continual crosstalk of host and microbiome
Brain is wired early, so day to day changes are probably mostly in the body, and the microbiome is a vital part of that.
Millions (trillions) of bacteria across our bodies, more similarity of regions across people than within person.
Brain is wired early, so day to day changes are probably mostly in the body, and the microbiome is a vital part of that.
Millions (trillions) of bacteria across our bodies, more similarity of regions across people than within person.