#SalivaryGland
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emmersonlab-irr.bsky.social
⏰ New preprint from @lizihegarty.bsky.social, @erinwatson.bsky.social, @bainlab.bsky.social & @doctoremmerson.bsky.social shows that 1hr in PFA-based fixative allows detection of #macrophage subsets in the #salivarygland, #pancreas & #kidney while preserving #epithelial & #endothelial architecture
biorxiv-immuno.bsky.social bioRxiv Immunology @biorxiv-immuno.bsky.social · 19h
Fixation matters: duration in fixative prior to immunofluorescent analysis directly impacts macrophage visualisation in epithelial tissues https://www.biorxiv.org/content/10.64898/2026.02.13.705745v1
February 16, 2026 at 5:56 PM
doctoremmerson.bsky.social
Our latest preprint, led by @lizihegarty.bsky.social & aided by @erinwatson.bsky.social shows that fixation time matters when it comes to visualising #macrophages in #salivarygland & other epithelia.We find 1hr allows detection of mac subsets while preserving architecture. With @bainlab.bsky.social
biorxiv-immuno.bsky.social bioRxiv Immunology @biorxiv-immuno.bsky.social · 19h
Fixation matters: duration in fixative prior to immunofluorescent analysis directly impacts macrophage visualisation in epithelial tissues https://www.biorxiv.org/content/10.64898/2026.02.13.705745v1
February 16, 2026 at 5:48 PM
jrheumatol.bsky.social
Research Article

A Stratification Approach Based on Salivary Gland Ultrasonography for Assessing Secretory Function in Sjögren Disease

📖 doi.org/10.3899/jrhe...

#SalivaryGland #SjögrenDisease
January 13, 2026 at 6:58 PM
azurelore.bsky.social
good show, salivarygland
November 23, 2025 at 11:34 AM
doctoremmerson.bsky.social
A beautiful study describing cell fate acquisition in bilayered #epithelia, inc. my fave #salivarygland, published in @cp-devcell.bsky.social

Conserved signals control self-organization & symmetry breaking of murine bilayered epithelia during development & regeneration

www.cell.com/developmenta...
Conserved signals control self-organization and symmetry breaking of murine bilayered epithelia during development and regeneration
Journot et al. explore fate specification during embryonic development and regeneration of bilayered glandular epithelia. They uncover conserved molecular mechanisms linking tissue architecture with c...
www.cell.com
October 26, 2025 at 10:57 AM
doctoremmerson.bsky.social
📖 A very comprehensive review of the heterogeneity, crosstalk and therapeutic potential of #salivarygland #macrophages including reference to several papers from @emmersonlab-irr.bsky.social
📚 #immunosky
www.frontiersin.org/journals/imm...
Frontiers | Salivary gland macrophages in health and disease: heterogeneity, niche crosstalk, and therapeutic avenues
Salivary glands (SGs) produce saliva essential for digestion, mucosal immunity, and as a source of non-invasive biomarkers. The health and pathology of SGs h...
www.frontiersin.org
October 19, 2025 at 3:36 PM
stemcellreports.bsky.social
New #salivarygland research! Human iPSC-derived salivary gland cell sheets integrate with injured glands to form glandular structures; a promising strategy for functional salivary gland regeneration. https://ow.ly/NfvL50X9sGR

ISSCR | The Gairdner Foundation | SickKids Foundation | Cell Press
October 10, 2025 at 3:20 PM
doctoremmerson.bsky.social
I am extremely honoured to say that I have been named as the @iadr.bsky.social Salivary Researcher of the Year 2025 🏆 This is testament to my incredible team & wonderful collaborators over the last 8 yrs & my superb postdoc training at @ucsanfrancisco.bsky.social #salivarygland #salivary #research
July 9, 2025 at 6:07 AM
doctoremmerson.bsky.social
As a postdoc I found that mimicking #nerve signals could help cell replenishment in #salivarygland. When I joined @edinuni-irr.bsky.social we teamed up with the incredible Unciti-Broceta lab from @uoe-igc.bsky.social to explore a novel #drugdelivery system: 📖 ➡️ www.researchsquare.com/article/rs-6...
Biodialyzed Palladium catalysis enables bioorthogonal drug release to control epithelial progenitor cell differentiation
Flowing from the principles of bioorthogonality, the introduction of abiotic transition metals for the catalytic production of drugs at specific anatomical locations has carved new paths to face chall...
www.researchsquare.com
July 3, 2025 at 8:48 AM
plosbiology.org
How does transcriptional patterning regulate #SalivaryGland #morphogenesis? Annabel May & @katjaroeper.bsky.social use #scRNAseq of early morphogenesis of the #Drosophila salivary gland placode to reveal regulation by induction & exclusion of regulatory factors @plosbiology.org 🧪 plos.io/4cUw827
Top: Immunofluorescence images and matching schematics of the anterior ventral half of Drosophila embryos at the indicated stages, highlighting the cells of the salivary gland placode, labelled with fkhGal4 x UAS-srcGFP. All cell outlines are labeled for phosphotyrosine to label adherens junctions (PY20, magenta) and srcGFP is in green, the stage 10 panel is shown with increased exposure, other panels are identical exposure. Scale bar is 100µm. Middle panels are matched schematics, showing the position of the salivary gland placode in pale green, the area of initial apical constriction in bright green and the forming invagination pit in black. Lower panels show schematics of cross sections (positioned indicated by magenta dotted lines in middle panels) of the invaginating tube. Bottom: A salivary gland placode in the Drosophila embryo at the onset of tube morphogenesis, labelled for four jointed (fj) (cyan) and fkh (magenta) expression by HCR and with cell outlines labelled by PY-20, detecting phospho-tyrosine at adherens junctions (yellow).
April 24, 2025 at 8:01 AM
plosbiology.org
How does transcriptional patterning regulate #SalivaryGland #morphogenesis? Annabel May & @katjaroeper.bsky.social use #scRNAseq of early morphogenesis of the #Drosophila salivary gland placode to reveal regulation by induction & exclusion of regulatory factors @plosbiology.org 🧪 plos.io/4cUw827
Top: Immunofluorescence images and matching schematics of the anterior ventral half of Drosophila embryos at the indicated stages, highlighting the cells of the salivary gland placode, labelled with fkhGal4 x UAS-srcGFP. All cell outlines are labeled for phosphotyrosine to label adherens junctions (PY20, magenta) and srcGFP is in green, the stage 10 panel is shown with increased exposure, other panels are identical exposure. Scale bar is 100µm. Middle panels are matched schematics, showing the position of the salivary gland placode in pale green, the area of initial apical constriction in bright green and the forming invagination pit in black. Lower panels show schematics of cross sections (positioned indicated by magenta dotted lines in middle panels) of the invaginating tube. Bottom: A salivary gland placode in the Drosophila embryo at the onset of tube morphogenesis, labelled for four jointed (fj) (cyan) and fkh (magenta) expression by HCR and with cell outlines labelled by PY-20, detecting phospho-tyrosine at adherens junctions (yellow).
April 23, 2025 at 5:18 PM
plosbiology.org
How does transcriptional patterning regulate #SalivaryGland #morphogenesis? Annabel May & @katjaroeper.bsky.social use #scRNAseq of early morphogenesis of the #Drosophila salivary gland placode to reveal regulation by induction & exclusion of regulatory factors @plosbiology.org 🧪 plos.io/4cUw827
Top: Immunofluorescence images and matching schematics of the anterior ventral half of Drosophila embryos at the indicated stages, highlighting the cells of the salivary gland placode, labelled with fkhGal4 x UAS-srcGFP. All cell outlines are labeled for phosphotyrosine to label adherens junctions (PY20, magenta) and srcGFP is in green, the stage 10 panel is shown with increased exposure, other panels are identical exposure. Scale bar is 100µm. Middle panels are matched schematics, showing the position of the salivary gland placode in pale green, the area of initial apical constriction in bright green and the forming invagination pit in black. Lower panels show schematics of cross sections (positioned indicated by magenta dotted lines in middle panels) of the invaginating tube. Bottom: A salivary gland placode in the Drosophila embryo at the onset of tube morphogenesis, labelled for four jointed (fj) (cyan) and fkh (magenta) expression by HCR and with cell outlines labelled by PY-20, detecting phospho-tyrosine at adherens junctions (yellow).
April 23, 2025 at 2:02 PM
doctoremmerson.bsky.social
Very nice study out now on @biorxivpreprint.bsky.social from Sarah Knox and co showing that cholinergic stimulation can improve function after salivary gland degeneration #salivarygland #headandneckcancer #regeneration www.biorxiv.org/content/10.1...
Chronic degenerative failure of salivary glands can be reversed through restoring mitochondrial function
There are no therapies for reversing chronic organ degeneration. Non-healing degenerative wounds are thought to be irreparable, in part, by the inability of the tissue to respond to reparative stimuli...
www.biorxiv.org
January 4, 2025 at 2:40 PM
doctoremmerson.bsky.social
This is absolutely incredible and led by our superb collaborator and ENT surgeon Iain Nixon #salivarygland #ENT #lothian #NHS www.bbc.co.uk/news/article...
'My surgeon saved my smile with hologram technology'
Susannah Morgan was warned surgery to remove a benign tumour could leave her with a crooked smile.
www.bbc.co.uk
January 2, 2025 at 2:12 PM
doctoremmerson.bsky.social
Just less than a month to apply for this exciting PhD project working toward #salivarygland #regeneration after #cancer treatment.
December 17, 2024 at 8:25 AM
doctoremmerson.bsky.social
A wonderful #EMDS2024! Thank you so much to the organisers for a superb meeting & for inviting me to speak about the @emmersonlab-irr.bsky.social work on #salivarygland #macrophages in such an incredible setting!
December 1, 2024 at 8:39 PM
doctoremmerson.bsky.social
If you're interested in joining us as a #PhD student at @edinuni-irr.bsky.social we are advertising a project to develop a localised #drug delivery system for #salivarygland #regeneration after #cancer #radiotherapy usher.ed.ac.uk/node/158254 Q&A session on 5/12/24, application deadline 13/01/25.
Developing a novel catalytic uncaging drug delivery system to deliver a focal therapy for post-radiotherapy tissue regeneration
Precision Medicine Project - Developing a novel catalytic uncaging drug delivery system to deliver a focal therapy for post-radiotherapy tissue regeneration
usher.ed.ac.uk
November 14, 2024 at 3:16 PM