JMJD5 regulates metabolism by inhibiting the Arginine Methyltransferase PRMT6 https://www.biorxiv.org/content/10.1101/2025.09.27.678987v1
September 29, 2025 at 1:30 PM
JMJD5 regulates metabolism by inhibiting the Arginine Methyltransferase PRMT6 https://www.biorxiv.org/content/10.1101/2025.09.27.678987v1
Generation of systemic rabbit chimeras via Induced Pluripotent Stem Cells Reprogrammed with KLF2, ERAS, and PRMT6 https://www.biorxiv.org/content/10.1101/2024.01.10.575048v1
Generation of systemic rabbit chimeras via Induced Pluripotent Stem Cells Reprogrammed with KLF2, ERAS, and PRMT6 https://www.biorxiv.org/content/10.1101/2024.01.10.575048v1
Little is known about the molecular underpinnings of pluripotent stem cells' (PSCs) ability to colon
www.biorxiv.org
January 12, 2024 at 8:34 AM
Generation of systemic rabbit chimeras via Induced Pluripotent Stem Cells Reprogrammed with KLF2, ERAS, and PRMT6 https://www.biorxiv.org/content/10.1101/2024.01.10.575048v1
Rabbit iPSCs reprogrammed with KLF2, ERAS, PRMT6 can create germline chimeras, achieving up to 100% organ contribution in embryos, fetuses, and newborns! PMID:40461482, Nat Commun 2025, @NatureComms https://doi.org/10.1038/s41467-025-60314-2 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Efficient generation of germline chimeras in a non-rodent species using rabbit induced pluripotent stem cells | Nature Communications
Pluripotent stem cells have long been used to produce knockout mice via germline chimera technology. However, aside from the rat, this approach has not been successfully applied to other mammals. Here, we demonstrate that rabbit induced pluripotent stem cells (iPSCs) can be reprogrammed using KLF2, ERAS and PRMT6, enabling them to efficiently colonize embryos. These chimeric embryos can develop into fetuses and newborn rabbits, with iPSCs contributing up to 100 % to certain organs. Notably, female rabbits generated through this method are healthy and transmit the iPSC genome to their offspring with a high efficiency, demonstrating germline chimerism. This advancement establishes a foundation for developing rabbit models of human disease with complex genetic traits. Pluripotent stem cells can integrate into embryos and contribute to all tissues, including the germline, when in a naïve state. Here, authors identify factors that reprogram rabbit iPSCs into a naïve-like state capable of ge
doi.org
September 18, 2025 at 2:10 AM
The RNA-binding protein RBM39 is a target of the anti-cancer agent Indisulam. Researchers at @pku1898.bsky.social show that RBM39 is methylated by PRMT6, which determines the resistance to Indisulam in lung #cancer models. 🧪
plos.io/4mJHk6p
plos.io/4mJHk6p
Methylation of RBM39 by PRMT6 enhances resistance to Indisulam in non-small cell lung cancer by promoting alternative splicing of proto-oncogenes
The RNA-binding protein RBM39 has been previously shown to be a target of the anti-cancer agent Indisulam. This study shows that RBM39 is methylated by PRMT6, which determines the resistance to Indisu...
plos.io
June 5, 2025 at 4:25 PM
The RNA-binding protein RBM39 is a target of the anti-cancer agent Indisulam. Researchers at @pku1898.bsky.social show that RBM39 is methylated by PRMT6, which determines the resistance to Indisulam in lung #cancer models. 🧪
plos.io/4mJHk6p
plos.io/4mJHk6p
Generation of systemic rabbit chimeras via Induced Pluripotent Stem Cells Reprogrammed with KLF2, ERAS, and PRMT6 https://www.biorxiv.org/content/10.1101/2024.01.10.575048v1
Generation of systemic rabbit chimeras via Induced Pluripotent Stem Cells Reprogrammed with KLF2, ERAS, and PRMT6 https://www.biorxiv.org/content/10.1101/2024.01.10.575048v1
Little is known about the molecular underpinnings of pluripotent stem cells' (PSCs) ability to colon
www.biorxiv.org
January 12, 2024 at 8:34 AM
Generation of systemic rabbit chimeras via Induced Pluripotent Stem Cells Reprogrammed with KLF2, ERAS, and PRMT6 https://www.biorxiv.org/content/10.1101/2024.01.10.575048v1
JMJD5 regulates metabolism by inhibiting the Arginine Methyltransferase PRMT6 https://www.biorxiv.org/content/10.1101/2025.09.27.678987v1
September 29, 2025 at 1:30 PM
JMJD5 regulates metabolism by inhibiting the Arginine Methyltransferase PRMT6 https://www.biorxiv.org/content/10.1101/2025.09.27.678987v1
To identify PRMTs involved in DSB repair, we investigated the accumulation and dissociation of PRMTs at DSB sites generated by localized 405 nm laser micro-irradiation in living cells. As a result, PRMT4/CARM1, PRMT6, and PRMT7 were identified as novel DSB-responsive factors.
August 6, 2025 at 9:23 AM
To identify PRMTs involved in DSB repair, we investigated the accumulation and dissociation of PRMTs at DSB sites generated by localized 405 nm laser micro-irradiation in living cells. As a result, PRMT4/CARM1, PRMT6, and PRMT7 were identified as novel DSB-responsive factors.
PRMT6, through its methyltransferase activity, contributes to alternative splicing in both pluripotent and neuronally differentiating NT2/D1 cells, affecting primarily cassette exons
https://buff.ly/4aNui1R
https://buff.ly/4aNui1R
February 5, 2025 at 4:04 PM
PRMT6, through its methyltransferase activity, contributes to alternative splicing in both pluripotent and neuronally differentiating NT2/D1 cells, affecting primarily cassette exons
https://buff.ly/4aNui1R
https://buff.ly/4aNui1R
🌶️Publication Alert🚨: CRUK Scotland, Uni Leicester & Uni Edinburgh find new #JMJD5 pathway and identify #PRMT6 as a potential therapeutic target for treating cancer! Enrichment of PhoX crosslinked peptides with #MagReSyn_Zr_IMAC_HP helped find the link! www.biorxiv.org/content/10.1...
October 7, 2025 at 12:34 PM
🌶️Publication Alert🚨: CRUK Scotland, Uni Leicester & Uni Edinburgh find new #JMJD5 pathway and identify #PRMT6 as a potential therapeutic target for treating cancer! Enrichment of PhoX crosslinked peptides with #MagReSyn_Zr_IMAC_HP helped find the link! www.biorxiv.org/content/10.1...
New article by Eudenbach et al:
Assessment of PRMT6-dependent alternative splicing in pluripotent and differentiating NT2/D1 cells https://buff.ly/4jJCXq7
Assessment of PRMT6-dependent alternative splicing in pluripotent and differentiating NT2/D1 cells https://buff.ly/4jJCXq7
February 5, 2025 at 9:34 PM
New article by Eudenbach et al:
Assessment of PRMT6-dependent alternative splicing in pluripotent and differentiating NT2/D1 cells https://buff.ly/4jJCXq7
Assessment of PRMT6-dependent alternative splicing in pluripotent and differentiating NT2/D1 cells https://buff.ly/4jJCXq7
New article by Eudenbach et al:
Assessment of PRMT6-dependent alternative splicing in pluripotent and differentiating NT2/D1 cells https://buff.ly/4jJCXq7
Assessment of PRMT6-dependent alternative splicing in pluripotent and differentiating NT2/D1 cells https://buff.ly/4jJCXq7
February 11, 2025 at 9:34 PM
New article by Eudenbach et al:
Assessment of PRMT6-dependent alternative splicing in pluripotent and differentiating NT2/D1 cells https://buff.ly/4jJCXq7
Assessment of PRMT6-dependent alternative splicing in pluripotent and differentiating NT2/D1 cells https://buff.ly/4jJCXq7
The RNA-binding protein RBM39 is a target of the anti-cancer agent Indisulam. Researchers at @pku1898.bsky.social show that RBM39 is methylated by PRMT6, which determines the resistance to Indisulam in lung #cancer models. 🧪
plos.io/4mJHk6p
plos.io/4mJHk6p
Methylation of RBM39 by PRMT6 enhances resistance to Indisulam in non-small cell lung cancer by promoting alternative splicing of proto-oncogenes
The RNA-binding protein RBM39 has been previously shown to be a target of the anti-cancer agent Indisulam. This study shows that RBM39 is methylated by PRMT6, which determines the resistance to Indisu...
plos.io
June 6, 2025 at 10:37 AM
The RNA-binding protein RBM39 is a target of the anti-cancer agent Indisulam. Researchers at @pku1898.bsky.social show that RBM39 is methylated by PRMT6, which determines the resistance to Indisulam in lung #cancer models. 🧪
plos.io/4mJHk6p
plos.io/4mJHk6p