Are headaches, poor sleep 😴, and an impaired glymphatic system causing the rise in p-tau181 among #LongCovid patients (cohort with a mean age of 56 years)?
It's a blood biomarker of brain inflammation tied to increased risk of Alzheimer's disease.
#neuroCOVID #medsky
thelancet.com/journals/ebi...
It's a blood biomarker of brain inflammation tied to increased risk of Alzheimer's disease.
#neuroCOVID #medsky
thelancet.com/journals/ebi...
Increased phosphorylated tau (pTau-181) is associated with neurological post-acute sequelae of coronavirus disease in essential workers: a prospective cohort study before and after COVID-19 onset
N-PASC with symptoms consistent with central damage were associated with increased
pTau-181 levels. Increases in pTau-181 were associated with increased risk of changes
to amyloid biomarkers consisten...
thelancet.com
January 15, 2026 at 6:40 PM
Are headaches, poor sleep 😴, and an impaired glymphatic system causing the rise in p-tau181 among #LongCovid patients (cohort with a mean age of 56 years)?
It's a blood biomarker of brain inflammation tied to increased risk of Alzheimer's disease.
#neuroCOVID #medsky
thelancet.com/journals/ebi...
It's a blood biomarker of brain inflammation tied to increased risk of Alzheimer's disease.
#neuroCOVID #medsky
thelancet.com/journals/ebi...
Wenn 'Fraihait'-Gröhlende ihren absoluten *Egoismus* für "ihr Grundrecht" halten - und die Gesundheitsgefährdung aller anderen (bis hin zu LongCovid und Tod) zur Folge haben !!
Einfach nur zutiefst beschämend! 🤦♀️🤬🤮
#KinderdurchseuchungStoppen #WirWerdenLaut #BildungAberSicher #ImpfenSchuetzt
Einfach nur zutiefst beschämend! 🤦♀️🤬🤮
#KinderdurchseuchungStoppen #WirWerdenLaut #BildungAberSicher #ImpfenSchuetzt
January 15, 2026 at 5:46 PM
Wenn 'Fraihait'-Gröhlende ihren absoluten *Egoismus* für "ihr Grundrecht" halten - und die Gesundheitsgefährdung aller anderen (bis hin zu LongCovid und Tod) zur Folge haben !!
Einfach nur zutiefst beschämend! 🤦♀️🤬🤮
#KinderdurchseuchungStoppen #WirWerdenLaut #BildungAberSicher #ImpfenSchuetzt
Einfach nur zutiefst beschämend! 🤦♀️🤬🤮
#KinderdurchseuchungStoppen #WirWerdenLaut #BildungAberSicher #ImpfenSchuetzt
Day 1224 — I don't know what worries me more. That I came up with it? That I made a thing with it? Or that I'm actually broadcasting it.
"COVID causes brain damage", they said.
Believe it.
#DadJoke #MECFS #LongCOVID #ChronicIllness #MedSky
"COVID causes brain damage", they said.
Believe it.
#DadJoke #MECFS #LongCOVID #ChronicIllness #MedSky
![What can the medical profession do when it’s searched through every potential treatment and cure, only to end up empty handed?
Re-search.
[*Takes a bow*]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:qdbjeqjdesxm5qcdsvufefqv/bafkreiejarm2pkeif2qwbkevtziw552zm5p7t3ehekcsnynrq5zn5mlseq@jpeg)
January 15, 2026 at 5:34 PM
Day 1224 — I don't know what worries me more. That I came up with it? That I made a thing with it? Or that I'm actually broadcasting it.
"COVID causes brain damage", they said.
Believe it.
#DadJoke #MECFS #LongCOVID #ChronicIllness #MedSky
"COVID causes brain damage", they said.
Believe it.
#DadJoke #MECFS #LongCOVID #ChronicIllness #MedSky
This study shows that people with #LongCOVID and neurological symptoms had a ~59% increase in plasma pTau-181 (a phosphorylated tau protein linked to Alzheimer’s pathology) relative to pre-COVID levels.
doi.org/10.1016/j.eb...
doi.org/10.1016/j.eb...
Redirecting
doi.org
January 15, 2026 at 5:33 PM
This study shows that people with #LongCOVID and neurological symptoms had a ~59% increase in plasma pTau-181 (a phosphorylated tau protein linked to Alzheimer’s pathology) relative to pre-COVID levels.
doi.org/10.1016/j.eb...
doi.org/10.1016/j.eb...
2/
While many of us infected in the First Wave of the pandemic, have now been living with #LongCOVID for nearly 6 years.
My son and I will mark that miserable anniversary in this March/April.
While many of us infected in the First Wave of the pandemic, have now been living with #LongCOVID for nearly 6 years.
My son and I will mark that miserable anniversary in this March/April.
January 15, 2026 at 5:17 PM
2/
While many of us infected in the First Wave of the pandemic, have now been living with #LongCOVID for nearly 6 years.
My son and I will mark that miserable anniversary in this March/April.
While many of us infected in the First Wave of the pandemic, have now been living with #LongCOVID for nearly 6 years.
My son and I will mark that miserable anniversary in this March/April.
1/
Just a reminder, that a 4-year analysis showed that -
"In the largest #LongCOVID cohort from a single specialist post-COVID service to date, only one-third of individuals under follow-up achieved satisfactory recovery":
bmjopen.bmj.com/content/16/1...
Just a reminder, that a 4-year analysis showed that -
"In the largest #LongCOVID cohort from a single specialist post-COVID service to date, only one-third of individuals under follow-up achieved satisfactory recovery":
bmjopen.bmj.com/content/16/1...
Trajectory, healthcare utilisation and recovery in 3590 individuals with long covid: a 4-year prospective cohort analysis
Objective To characterise long-term trajectory of recovery in individuals with long covid.
Design Prospective cohort.
Setting Single-centre, specialist post-COVID service (London, UK).
Participants...
bmjopen.bmj.com
January 15, 2026 at 5:17 PM
1/
Just a reminder, that a 4-year analysis showed that -
"In the largest #LongCOVID cohort from a single specialist post-COVID service to date, only one-third of individuals under follow-up achieved satisfactory recovery":
bmjopen.bmj.com/content/16/1...
Just a reminder, that a 4-year analysis showed that -
"In the largest #LongCOVID cohort from a single specialist post-COVID service to date, only one-third of individuals under follow-up achieved satisfactory recovery":
bmjopen.bmj.com/content/16/1...
Absolut. Ebenso schulterzuckend so zu tun, als sei Covid „wie Grippe“, um zu implizieren, es sei harmlos oder unvermeidbar. Und gleichzeitig LongCovid- und ME/CFS-Betroffenen keinerlei Unterstützung zukommen zu lassen, häufig noch nicht mal Diagnostik. Das zerstört Biografien.
January 15, 2026 at 5:16 PM
Absolut. Ebenso schulterzuckend so zu tun, als sei Covid „wie Grippe“, um zu implizieren, es sei harmlos oder unvermeidbar. Und gleichzeitig LongCovid- und ME/CFS-Betroffenen keinerlei Unterstützung zukommen zu lassen, häufig noch nicht mal Diagnostik. Das zerstört Biografien.
Bluesky's Top 10 Trending Words (past 10min):
💨x149 - jenrick
💨x1* - epstein 🔓
💨x1* - democracy 🔓
💨x1* - ukraine 🔓
💨x1* - gaza 🔓
💨x29 - insurrection
💨x24 - 1﹐671
💨x21 - badenoch
💨x20 - invoke
💨x19 - snk
*🔓 = Unlocked Emergency Words (see img)
#йобанарусня 🇺🇦
(Something not right? Reply!)
![Emoji Legend
💨x# | "Increased Trending Rate" for a Word (meaningful value; "💨x8 - burger" will mean "burger" is trending at 8 times its own normal rate for this time of day)
🔓 | "Unlocked" Ongoing Emergency Word (such words are not weighted down by their own previous usage; their *ongoing* increased usage--weeks, months, years--would otherwise move them down the list.)
[PREVIOUSLY USED]
⚠️💨# | "Trend Strength Rating"
⚠️🌀💨 | "Trend Strength Rating" (see above)
⚠️🌀 CAT. # | [same; "CAT." = Category, like hurricane]
💬# | 10min Post Count
🆎# | 10min Word Count
🙂# | 10min Emoji Count](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:mcb6n67plnrlx4lg35natk2b/bafkreigp6bgag3jzkool6uxrujpcrwtn6zkd7cbfrmevhaxaqhhewgolmu@jpeg)
January 15, 2026 at 5:10 PM
As far as I'm concerned, #pwME require treatments which target immune and mitochondria dysfunction. Are any forthcoming? If so, will they be approved by NICE for use in the NHS, and when? #MyalgicEncephalomyelitis #MECFS #LongCOVID
January 15, 2026 at 5:07 PM
As far as I'm concerned, #pwME require treatments which target immune and mitochondria dysfunction. Are any forthcoming? If so, will they be approved by NICE for use in the NHS, and when? #MyalgicEncephalomyelitis #MECFS #LongCOVID
5/
"Epigenetically, LC-Mo exhibited AP-1- and NF-κB1-driven profibrotic programs".
(* For further reading on the "profibrotic" aspect, see also @resiapretorius.bsky.social & @dbkell.bsky.social's extensive research on amyloid fibrin microclots in #LongCOVID).
"Epigenetically, LC-Mo exhibited AP-1- and NF-κB1-driven profibrotic programs".
(* For further reading on the "profibrotic" aspect, see also @resiapretorius.bsky.social & @dbkell.bsky.social's extensive research on amyloid fibrin microclots in #LongCOVID).
January 15, 2026 at 5:06 PM
5/
"Epigenetically, LC-Mo exhibited AP-1- and NF-κB1-driven profibrotic programs".
(* For further reading on the "profibrotic" aspect, see also @resiapretorius.bsky.social & @dbkell.bsky.social's extensive research on amyloid fibrin microclots in #LongCOVID).
"Epigenetically, LC-Mo exhibited AP-1- and NF-κB1-driven profibrotic programs".
(* For further reading on the "profibrotic" aspect, see also @resiapretorius.bsky.social & @dbkell.bsky.social's extensive research on amyloid fibrin microclots in #LongCOVID).
3/
We urgently need to develop an understanding of the mechanism of this extremely debilitating symptom of #LongCOVID, & an effective treatment.
Herewith one of the latest research papers that examines pulmonary impairment in #LongCOVID -
bsky.app/profile/labw...
We urgently need to develop an understanding of the mechanism of this extremely debilitating symptom of #LongCOVID, & an effective treatment.
Herewith one of the latest research papers that examines pulmonary impairment in #LongCOVID -
bsky.app/profile/labw...
A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID @natimmunol.nature.com @saumkmr.bsky.social @ciim-hannover.bsky.social @jie-immunology.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 15, 2026 at 5:06 PM
3/
We urgently need to develop an understanding of the mechanism of this extremely debilitating symptom of #LongCOVID, & an effective treatment.
Herewith one of the latest research papers that examines pulmonary impairment in #LongCOVID -
bsky.app/profile/labw...
We urgently need to develop an understanding of the mechanism of this extremely debilitating symptom of #LongCOVID, & an effective treatment.
Herewith one of the latest research papers that examines pulmonary impairment in #LongCOVID -
bsky.app/profile/labw...
2/
I had the same symptom for the first couple of years of my own #LongCOVID. I understand the feeling of suffocation.
Despite apparent "healthy" pulse oximetry readings, the respiratory distress is real (not imagined). I also had accompanying cyanotic lips & hands.
I had the same symptom for the first couple of years of my own #LongCOVID. I understand the feeling of suffocation.
Despite apparent "healthy" pulse oximetry readings, the respiratory distress is real (not imagined). I also had accompanying cyanotic lips & hands.
January 15, 2026 at 5:06 PM
2/
I had the same symptom for the first couple of years of my own #LongCOVID. I understand the feeling of suffocation.
Despite apparent "healthy" pulse oximetry readings, the respiratory distress is real (not imagined). I also had accompanying cyanotic lips & hands.
I had the same symptom for the first couple of years of my own #LongCOVID. I understand the feeling of suffocation.
Despite apparent "healthy" pulse oximetry readings, the respiratory distress is real (not imagined). I also had accompanying cyanotic lips & hands.
1/
Six years into #LongCOVID, my son keeps ending up in the ER with extreme air hunger (dyspnea doesn't quite describe it).
Worryingly, there appear to be no treatments besides Prednisone, a steroid one shouldn't take too often.
Six years into #LongCOVID, my son keeps ending up in the ER with extreme air hunger (dyspnea doesn't quite describe it).
Worryingly, there appear to be no treatments besides Prednisone, a steroid one shouldn't take too often.
January 15, 2026 at 5:06 PM
1/
Six years into #LongCOVID, my son keeps ending up in the ER with extreme air hunger (dyspnea doesn't quite describe it).
Worryingly, there appear to be no treatments besides Prednisone, a steroid one shouldn't take too often.
Six years into #LongCOVID, my son keeps ending up in the ER with extreme air hunger (dyspnea doesn't quite describe it).
Worryingly, there appear to be no treatments besides Prednisone, a steroid one shouldn't take too often.
Breek mij den muil niet open over Covid hoor!!
Ik lig al drie jaar 24/7 met oordoppen in in een verduisterde kamer.
#LongCovid
En Jenssen was toch een man, of zit ik fout?
#Overgang
Ik lig al drie jaar 24/7 met oordoppen in in een verduisterde kamer.
#LongCovid
En Jenssen was toch een man, of zit ik fout?
#Overgang
January 15, 2026 at 5:03 PM
Breek mij den muil niet open over Covid hoor!!
Ik lig al drie jaar 24/7 met oordoppen in in een verduisterde kamer.
#LongCovid
En Jenssen was toch een man, of zit ik fout?
#Overgang
Ik lig al drie jaar 24/7 met oordoppen in in een verduisterde kamer.
#LongCovid
En Jenssen was toch een man, of zit ik fout?
#Overgang
Good news : the #EBV virus is involved in a lot of nasty innuje diseases, including #longcovid and #mecfs
Epstein-Barr Virus #EBV was linked to #MultipleSclerosis - now a plausible cause has been found, misidentification by longterm memory T-cells that pick on the wrong protein, ANO2, instead of the EBV-antigen. Massive inflection towards the elimination of MS!!!
🧪🧠Cell www.cell.com/cell/fulltex...
🧪🧠Cell www.cell.com/cell/fulltex...
Anoctamin-2-specific T cells link Epstein-Barr virus to multiple sclerosis
Researchers identified anoctamin-2 (ANO2) as a frequent autoimmune target in multiple
sclerosis, with T cell responses against ANO2 occurring in over half of patients.
These ANO2-specific T cells shar...
www.cell.com
January 15, 2026 at 4:56 PM
Good news : the #EBV virus is involved in a lot of nasty innuje diseases, including #longcovid and #mecfs
Weiterhin gilt (auch mit Blick auf die hohe Zahl LongCovid-Fälle) #CovidIsNotOver - aber viele wollen das ja *nicht* wahrhaben ... oder meinten gar, #COVID19 nach Einstellung fast aller Testungen 2023 per Order für "beendet" erklären zu können. 🤔🤦♀️
#KinderdurchseuchungStoppen @suse1603.bsky.social
#KinderdurchseuchungStoppen @suse1603.bsky.social
January 15, 2026 at 4:45 PM
Weiterhin gilt (auch mit Blick auf die hohe Zahl LongCovid-Fälle) #CovidIsNotOver - aber viele wollen das ja *nicht* wahrhaben ... oder meinten gar, #COVID19 nach Einstellung fast aller Testungen 2023 per Order für "beendet" erklären zu können. 🤔🤦♀️
#KinderdurchseuchungStoppen @suse1603.bsky.social
#KinderdurchseuchungStoppen @suse1603.bsky.social
./4
Bedenke: Jede(!) weitere Reinfektion, auch asymptomatisch, ist eine erneute Lotterie-Teilnahme für #LongCovid !🧐
Mit jeder #Covid19 Reinfektion kumuliert das Risiko. Das bedeutet, mit jeder Infektion wird das Risiko größer (LongCovid, teils lebenslange Beeinträchtigungen)! Wird so hingenommen?🤬
Bedenke: Jede(!) weitere Reinfektion, auch asymptomatisch, ist eine erneute Lotterie-Teilnahme für #LongCovid !🧐
Mit jeder #Covid19 Reinfektion kumuliert das Risiko. Das bedeutet, mit jeder Infektion wird das Risiko größer (LongCovid, teils lebenslange Beeinträchtigungen)! Wird so hingenommen?🤬
January 15, 2026 at 4:45 PM
./4
Bedenke: Jede(!) weitere Reinfektion, auch asymptomatisch, ist eine erneute Lotterie-Teilnahme für #LongCovid !🧐
Mit jeder #Covid19 Reinfektion kumuliert das Risiko. Das bedeutet, mit jeder Infektion wird das Risiko größer (LongCovid, teils lebenslange Beeinträchtigungen)! Wird so hingenommen?🤬
Bedenke: Jede(!) weitere Reinfektion, auch asymptomatisch, ist eine erneute Lotterie-Teilnahme für #LongCovid !🧐
Mit jeder #Covid19 Reinfektion kumuliert das Risiko. Das bedeutet, mit jeder Infektion wird das Risiko größer (LongCovid, teils lebenslange Beeinträchtigungen)! Wird so hingenommen?🤬
![Lucibee [Dec 21, 2022]: It's such a shame this is such a mess, because their hearts and aims seem to be in the right place.
QT Manoj Sivan [Apr 27, 2022]: Need for consistent advice on how to return to physical activity after Covid. Our paper (with @astillSL and @LeedsMsc) highlights the current dilemmas. Thanks to all who participated in this study.
https://leeds.ac.uk/main-index/news/article/5071/exercise-warnings-over-long-covid-recovery #LongCovid @LCHNHSTrust @LeedsHospitals @UniversityLeeds](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:idf6m3amxguxiftesf7y24hd/bafkreigii2xsufcsrjxmpo6gr65qyypte5q3p4xpjudwt5ffikakgj4fue@jpeg)
With one eye on elections, politicians have expediently co-opted public health.
Vote for leaders who acknowledge we are still in an #OngoingPandemic, know that #COVID is #Airborne, & that everyone is at risk of #LongCOVID after enough #Reinfections.
Political will is likely the only way out -
Vote for leaders who acknowledge we are still in an #OngoingPandemic, know that #COVID is #Airborne, & that everyone is at risk of #LongCOVID after enough #Reinfections.
Political will is likely the only way out -
Zack Polanski has also mentioned long covid. I am voting Green Party.
January 15, 2026 at 4:21 PM
With one eye on elections, politicians have expediently co-opted public health.
Vote for leaders who acknowledge we are still in an #OngoingPandemic, know that #COVID is #Airborne, & that everyone is at risk of #LongCOVID after enough #Reinfections.
Political will is likely the only way out -
Vote for leaders who acknowledge we are still in an #OngoingPandemic, know that #COVID is #Airborne, & that everyone is at risk of #LongCOVID after enough #Reinfections.
Political will is likely the only way out -
Endlich ein Paper, das den biologischen Rhythmus bei #PostCovid und #MECFS einbezieht! Chronobiologie und Multi-Omics helfen, #LongCovid-Symptome im Menstruationszyklus zu entschlüsseln.
(Auch #PEM wurden bisher oft ignoriert und #MECFS als "statisch" missverstanden.)
www.nature.com/articles/s44...
(Auch #PEM wurden bisher oft ignoriert und #MECFS als "statisch" missverstanden.)
www.nature.com/articles/s44...
A chronobiology-based protocol for multi-omic mapping of menstrual cycle and diurnal rhythms in ME/CFS and long COVID - npj Women's Health
npj Women's Health - A chronobiology-based protocol for multi-omic mapping of menstrual cycle and diurnal rhythms in ME/CFS and long COVID
www.nature.com
January 15, 2026 at 4:18 PM
Endlich ein Paper, das den biologischen Rhythmus bei #PostCovid und #MECFS einbezieht! Chronobiologie und Multi-Omics helfen, #LongCovid-Symptome im Menstruationszyklus zu entschlüsseln.
(Auch #PEM wurden bisher oft ignoriert und #MECFS als "statisch" missverstanden.)
www.nature.com/articles/s44...
(Auch #PEM wurden bisher oft ignoriert und #MECFS als "statisch" missverstanden.)
www.nature.com/articles/s44...
12/n
Misunderstandings about Borg.
Misunderstandings about Borg.
![Lucibee: The above middle paragraph is missing from their own leaflet on #LongCovid rehab.
See pages 44-45: https://flipbooks.leedsth.nhs.uk/LN005039.pdf
Comparing the two documents, it simply doesn't make sense. They [the Leeds team] seem to fundamentally misunderstand what the Borg scale is for.
It's not the level of exertion that you should aim to work at; it's what you perceive exertion to be at a certain level of activity.
Let's compare the phase 2 descriptions.
On the left is the WHO doc.
On the right is the Leeds doc. [see subsequent images]
There seems to be some important information missing from the Leeds doc. [also, "working at"? ... that's not what Borg is for!]
[Tweets from Dec 16, 2022]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:idf6m3amxguxiftesf7y24hd/bafkreiep3knwwcu6m7fvicdepsjl7qkz2xbfwg3rxo2hl5ucf7misasoti@jpeg)
January 15, 2026 at 4:12 PM
12/n
Misunderstandings about Borg.
Misunderstandings about Borg.
📄 Health records study estimated 100,000+ Americans died each year between 2022 and 2024 from COVID-19
🫁 New study found further evidence of abnormalities in PEM
💉 Small clinical trial is testing Ketamine for Long COVID fatigue & cognitive function
#LongCOVID research updates: bit.ly/4qZcW9m
🫁 New study found further evidence of abnormalities in PEM
💉 Small clinical trial is testing Ketamine for Long COVID fatigue & cognitive function
#LongCOVID research updates: bit.ly/4qZcW9m
January 15, 2026 at 4:03 PM
📄 Health records study estimated 100,000+ Americans died each year between 2022 and 2024 from COVID-19
🫁 New study found further evidence of abnormalities in PEM
💉 Small clinical trial is testing Ketamine for Long COVID fatigue & cognitive function
#LongCOVID research updates: bit.ly/4qZcW9m
🫁 New study found further evidence of abnormalities in PEM
💉 Small clinical trial is testing Ketamine for Long COVID fatigue & cognitive function
#LongCOVID research updates: bit.ly/4qZcW9m
Increased levels of Alzheimer’s-linked protein found in some with long COVID
Medical Xpress
January 13, 2026
By Stony Brook University
stillcoviding.ca/en/news/incr...
#LongCovid #AlzheimersDisease #CovidIsNotOver
Medical Xpress
January 13, 2026
By Stony Brook University
stillcoviding.ca/en/news/incr...
#LongCovid #AlzheimersDisease #CovidIsNotOver
Increased levels of Alzheimer’s-linked protein found in some with long COVID
stillcoviding.ca
January 15, 2026 at 3:45 PM
Increased levels of Alzheimer’s-linked protein found in some with long COVID
Medical Xpress
January 13, 2026
By Stony Brook University
stillcoviding.ca/en/news/incr...
#LongCovid #AlzheimersDisease #CovidIsNotOver
Medical Xpress
January 13, 2026
By Stony Brook University
stillcoviding.ca/en/news/incr...
#LongCovid #AlzheimersDisease #CovidIsNotOver