It's going to be interesting if FXIa inhibitors like Milvexian and Asundaxian will increase infection risk
April 30, 2025 at 3:12 PM
It's going to be interesting if FXIa inhibitors like Milvexian and Asundaxian will increase infection risk
Dropbox Pro FOR LIFE! 50 GB free cloud storage. <a href="http://appsumo.com/~FxIA" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">http://appsumo.com/~FxIA via @appsumo
AppSumo: The Store for Entrepreneurs
AppSumo promotes great products to help you in your caree...
appsumo.com
November 19, 2024 at 2:14 PM
Dropbox Pro FOR LIFE! 50 GB free cloud storage. <a href="http://appsumo.com/~FxIA" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">http://appsumo.com/~FxIA via @appsumo
📊 Où en sommes nous du développement des nouveaux anticoagulants anti-FXI et anti-FXIa en 2024❓
💉La percée des anticorps monoclonaux.
💊 Le doute sur l'efficacité d'un anti-FXIa oral
🌐 Notre review 🇫🇷 dans les Annales de Biologie Clinique
www.jle.com/fr/revues/ab...
💉La percée des anticorps monoclonaux.
💊 Le doute sur l'efficacité d'un anti-FXIa oral
🌐 Notre review 🇫🇷 dans les Annales de Biologie Clinique
www.jle.com/fr/revues/ab...
November 17, 2024 at 8:18 PM
📊 Où en sommes nous du développement des nouveaux anticoagulants anti-FXI et anti-FXIa en 2024❓
💉La percée des anticorps monoclonaux.
💊 Le doute sur l'efficacité d'un anti-FXIa oral
🌐 Notre review 🇫🇷 dans les Annales de Biologie Clinique
www.jle.com/fr/revues/ab...
💉La percée des anticorps monoclonaux.
💊 Le doute sur l'efficacité d'un anti-FXIa oral
🌐 Notre review 🇫🇷 dans les Annales de Biologie Clinique
www.jle.com/fr/revues/ab...
BMY Gains Attention as Bayer Reports FXIa Trial Success
BMY Gains Attention as Bayer Reports FXIa Trial Success | BeyondLINK
beyondlink.live
November 30, 2025 at 7:51 PM
BMY Gains Attention as Bayer Reports FXIa Trial Success
8 years ago today I watched a movie for my YouTube show so awful it almost made me break my "no screaming like the Nostalgia Critic" rule. www.youtube.com/watch?v=FXiA...
Shameless Cashgrab Episode 4: My Mom's A Werewolf (1989)
YouTube video by Arkle Studios
www.youtube.com
June 15, 2025 at 11:46 PM
8 years ago today I watched a movie for my YouTube show so awful it almost made me break my "no screaming like the Nostalgia Critic" rule. www.youtube.com/watch?v=FXiA...
7/The following strategies are currently in clinical development.
January 14, 2026 at 8:10 PM
7/The following strategies are currently in clinical development.
BMS, J&J's FXIa inhibitor milvexian fails first pivotal test firstwordpharma.com/story/6640661
November 14, 2025 at 1:06 PM
BMS, J&J's FXIa inhibitor milvexian fails first pivotal test firstwordpharma.com/story/6640661
October: Redemption of the FXIa Class
At #WSC2025, OCEANIC-STROKE provided a major win the class desperately needed. Unlike the AF trial, asundexian in secondary prevention hit its mark. We're all eagerly awaiting the full publication.
At #WSC2025, OCEANIC-STROKE provided a major win the class desperately needed. Unlike the AF trial, asundexian in secondary prevention hit its mark. We're all eagerly awaiting the full publication.
December 17, 2025 at 9:02 PM
October: Redemption of the FXIa Class
At #WSC2025, OCEANIC-STROKE provided a major win the class desperately needed. Unlike the AF trial, asundexian in secondary prevention hit its mark. We're all eagerly awaiting the full publication.
At #WSC2025, OCEANIC-STROKE provided a major win the class desperately needed. Unlike the AF trial, asundexian in secondary prevention hit its mark. We're all eagerly awaiting the full publication.
Updates on FXIa inhibitors!
🩸 New study from Matthew Bunce reveals ways to reverse milvexian, a novel FXIa inhibitor.
🧪 Activated PCCs & rFVIIa can neutralize its anticoagulant effects in emergencies. www.rpthjournal.org/article/S247...
🩸 New study from Matthew Bunce reveals ways to reverse milvexian, a novel FXIa inhibitor.
🧪 Activated PCCs & rFVIIa can neutralize its anticoagulant effects in emergencies. www.rpthjournal.org/article/S247...
December 4, 2024 at 9:33 PM
Updates on FXIa inhibitors!
🩸 New study from Matthew Bunce reveals ways to reverse milvexian, a novel FXIa inhibitor.
🧪 Activated PCCs & rFVIIa can neutralize its anticoagulant effects in emergencies. www.rpthjournal.org/article/S247...
🩸 New study from Matthew Bunce reveals ways to reverse milvexian, a novel FXIa inhibitor.
🧪 Activated PCCs & rFVIIa can neutralize its anticoagulant effects in emergencies. www.rpthjournal.org/article/S247...
#Bales2025FilmChallenge / #Bales2025MovieChallenge #FilmSky
June 21 – Someone skateboarding
🎞️ MID90S
📋 boxd.it/fxIa
June 21 – Someone skateboarding
🎞️ MID90S
📋 boxd.it/fxIa
June 21, 2025 at 10:45 AM
#Bales2025FilmChallenge / #Bales2025MovieChallenge #FilmSky
June 21 – Someone skateboarding
🎞️ MID90S
📋 boxd.it/fxIa
June 21 – Someone skateboarding
🎞️ MID90S
📋 boxd.it/fxIa
How effective targeting FXIa in preventing DVT?
Excellent new study from Oguri shows that FXI is present in clots, and targeting FXI with ONO-1600568 is as effective as rivaroxaban in reducing clot and fibrin deposition in a pre-clinical model.
Check it out!
www.rpthjournal.org/article/S247...
Excellent new study from Oguri shows that FXI is present in clots, and targeting FXI with ONO-1600568 is as effective as rivaroxaban in reducing clot and fibrin deposition in a pre-clinical model.
Check it out!
www.rpthjournal.org/article/S247...
April 16, 2025 at 12:03 PM
How effective targeting FXIa in preventing DVT?
Excellent new study from Oguri shows that FXI is present in clots, and targeting FXI with ONO-1600568 is as effective as rivaroxaban in reducing clot and fibrin deposition in a pre-clinical model.
Check it out!
www.rpthjournal.org/article/S247...
Excellent new study from Oguri shows that FXI is present in clots, and targeting FXI with ONO-1600568 is as effective as rivaroxaban in reducing clot and fibrin deposition in a pre-clinical model.
Check it out!
www.rpthjournal.org/article/S247...
BMY Gains Attention as Bayer Reports FXIa Trial Success
BMY Gains Attention as Bayer Reports FXIa Trial Success | BeyondLINK
beyondlink.live
November 30, 2025 at 7:51 PM
BMY Gains Attention as Bayer Reports FXIa Trial Success
6/FXI/XIa inhibitors decouple thrombosis from hemostasis by targeting the thrombin amplification loop (where thrombin normally acts on FXI to activate FXIa).
January 14, 2026 at 8:10 PM
6/FXI/XIa inhibitors decouple thrombosis from hemostasis by targeting the thrombin amplification loop (where thrombin normally acts on FXI to activate FXIa).
[Animatic] CHATTERING LACK OF COMMON SENSE | Halloween Special
YouTube video by Kimberly GB
www.youtube.com
October 31, 2024 at 6:17 PM
For #MovieChallenge Week 24 I watched Jonah Hill's directorial debut, Mid90s.
I have to admit I was a bit disappointed with this. I was expecting an out and out comedy, but he puts more of an emphasis on the drama here.
mid90s on Letterboxd
x.com/CineChallenges… boxd.it/fxIa
I have to admit I was a bit disappointed with this. I was expecting an out and out comedy, but he puts more of an emphasis on the drama here.
mid90s on Letterboxd
x.com/CineChallenges… boxd.it/fxIa
mid90s (2018)
In 1990s Los Angeles, a 13-year-old spends his summer navigating between a troubled home life and a crew of new friends he meets at a skate shop.
boxd.it
January 2, 2025 at 12:01 AM
For #MovieChallenge Week 24 I watched Jonah Hill's directorial debut, Mid90s.
I have to admit I was a bit disappointed with this. I was expecting an out and out comedy, but he puts more of an emphasis on the drama here.
mid90s on Letterboxd
x.com/CineChallenges… boxd.it/fxIa
I have to admit I was a bit disappointed with this. I was expecting an out and out comedy, but he puts more of an emphasis on the drama here.
mid90s on Letterboxd
x.com/CineChallenges… boxd.it/fxIa
4b) That brings up the concept of a #hemostasis-sparing #anticoagulant, as we have discussed in prior programs. Specific #FXI/#FXIa inhibitors might be just that, as they would impact only the intrinsic #coagulation pathway.
December 12, 2024 at 8:23 PM
4b) That brings up the concept of a #hemostasis-sparing #anticoagulant, as we have discussed in prior programs. Specific #FXI/#FXIa inhibitors might be just that, as they would impact only the intrinsic #coagulation pathway.
3b) Which is FALSE about #FXI/XIa-targeted agents in development?
a. multiple #MOAs are being tested
b. both FXI & FXIa are potential 🎯s
c. Pts on #OAPs are excluded from FXI/XIa #AF trials
d. a Ph 2 trial of a FXI inhibitor was stopped early for superior safety v a DOAC
Answer in the comments!
a. multiple #MOAs are being tested
b. both FXI & FXIa are potential 🎯s
c. Pts on #OAPs are excluded from FXI/XIa #AF trials
d. a Ph 2 trial of a FXI inhibitor was stopped early for superior safety v a DOAC
Answer in the comments!
December 12, 2024 at 8:23 PM
3b) Which is FALSE about #FXI/XIa-targeted agents in development?
a. multiple #MOAs are being tested
b. both FXI & FXIa are potential 🎯s
c. Pts on #OAPs are excluded from FXI/XIa #AF trials
d. a Ph 2 trial of a FXI inhibitor was stopped early for superior safety v a DOAC
Answer in the comments!
a. multiple #MOAs are being tested
b. both FXI & FXIa are potential 🎯s
c. Pts on #OAPs are excluded from FXI/XIa #AF trials
d. a Ph 2 trial of a FXI inhibitor was stopped early for superior safety v a DOAC
Answer in the comments!
New Video Live! 🎣🔥: “Scouting a Hidden Urban Stream for Fish! 🎣💦 Looks Dirty, But Worth a Try—Stay Tuned! #UrbanFishing“ 🎥 Watch here: www.youtube.com/watch?v=fXiA... 👍 Like, share & subscribe for more fishing action! #Fishing #Angling #FishingUK #CatchAndRelease #FishingLife
Scouting a Hidden Urban Stream for Fish! 🎣💦 Looks Dirty, But Worth a Try—Stay Tuned! #UrbanFishing
🎣 Urban fishing adventure! I explored a hidden stream running under a road bridge in town to see if it holds any fish. At first glance, the water looks murk...
www.youtube.com
March 21, 2025 at 1:49 PM
New Video Live! 🎣🔥: “Scouting a Hidden Urban Stream for Fish! 🎣💦 Looks Dirty, But Worth a Try—Stay Tuned! #UrbanFishing“ 🎥 Watch here: www.youtube.com/watch?v=fXiA... 👍 Like, share & subscribe for more fishing action! #Fishing #Angling #FishingUK #CatchAndRelease #FishingLife
9) Another small molecule, #asundexian, was being studied vs #apixaban for #SPAF in #OCEANIC_AF, but that trial was prematurely terminated due to inferior efficacy of the #FXIa inhibitor. See pubmed.ncbi.nlm.nih.gov/39225267/ & discussion by @CMichaelGibson at cardiometabolic-ce.com/antithrombot....
Asundexian versus Apixaban in Patients with Atrial Fibrillation - PubMed
Among patients with atrial fibrillation at risk for stroke, treatment with asundexian at a dose of 50 mg once daily was associated with a higher incidence of stroke or systemic embolism than treatment...
pubmed.ncbi.nlm.nih.gov
December 12, 2024 at 8:23 PM
9) Another small molecule, #asundexian, was being studied vs #apixaban for #SPAF in #OCEANIC_AF, but that trial was prematurely terminated due to inferior efficacy of the #FXIa inhibitor. See pubmed.ncbi.nlm.nih.gov/39225267/ & discussion by @CMichaelGibson at cardiometabolic-ce.com/antithrombot....
Rückschlag für Bayer bei der Entwicklung eines neuen direkten Antikoagulanz: OCEANIC-AF-Studie mit dem neuen Wirkstoff Asundexian (FXIa-Antagonist) im Vergleich zu Apixaban wurde auf Grund von Unterlegenheit von Asundexian vorzeitig abgebrochen.
Site Maintenance
www.bayer.com
November 20, 2023 at 8:27 PM
Rückschlag für Bayer bei der Entwicklung eines neuen direkten Antikoagulanz: OCEANIC-AF-Studie mit dem neuen Wirkstoff Asundexian (FXIa-Antagonist) im Vergleich zu Apixaban wurde auf Grund von Unterlegenheit von Asundexian vorzeitig abgebrochen.
8a) Since #FXI was identified as a potential target for #anticoagulation with less bleeding risk (supported by genomic & epidemiologic studies of ppl with inborn FXI deficiency & by animal studies), multiple approaches to inhibition of FXI zymogen or #FXIa activity are being studied.
December 12, 2024 at 8:23 PM
8a) Since #FXI was identified as a potential target for #anticoagulation with less bleeding risk (supported by genomic & epidemiologic studies of ppl with inborn FXI deficiency & by animal studies), multiple approaches to inhibition of FXI zymogen or #FXIa activity are being studied.
Followed by the worst movie of Season 1, My Mom's a Werewolf. www.youtube.com/watch?v=FXiA...
Shameless Cashgrab Episode 4: My Mom's A Werewolf (1989)
YouTube video by Arkle Studios
www.youtube.com
October 11, 2025 at 12:41 PM
Followed by the worst movie of Season 1, My Mom's a Werewolf. www.youtube.com/watch?v=FXiA...