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acr-journals.bsky.social
Now published: The 2025 ACR Guideline for the Treatment of Systemic Lupus Erythematosus

📄 Read the paper: acr.tw/47mkegj

ℹ️ See additional content and resources on this guideline at acr.tw/4mbHK4W

#Medsky #Rheumsky #Rheumatology
Overview of the recommended management for systemic lupus erythematosus (SLE). This schematic illustrates the approach to SLE treatment, with organ-specific therapies presented in separate boxes and stratified by disease severity. The order of the medications in each box does not indicate preference unless noted otherwise. Lupus nephritis treatment is addressed in the 2025 American College of Rheumatology Guideline for the Screening, Treatment, and Management of Lupus Nephritis. ABBREVIATIONS: ACLE, acute cutaneous lupus erythematosus; SCLE, subacute cutaneous lupus erythematosus; CCLE, chronic cutaneous lupus erythematosus; CNI, calcineurin inhibitor (cyclosporin or tacrolimus); HCQ, hydroxychloroquine; CQ, chloroquine; CCB, calcium channel blockers; IL-1 blockade, Interleukin-1 blockade; IS, immunosuppressive therapy; IV CYC, intravenous cyclophosphamide; IVIG, intravenous immunoglobulins; LCV, leukocytoclastic vasculitis; MPAA, mycophenolic acid analogs; NSAIDs, non-steroidal anti-inflammatory drugs; PDE5i, phosphodiesterase type 5 inhibitors; PLEX, plasma exchange. FOOTNOTES: ** In CLE, switch HCQ to CQ with the intention of changing back to HCQ once the rash is under control. † Azathioprine may be used when pregnancy is planned. Based on the Voting Panel members’ clinical experience, anifrolumab has a more rapid onset of benefit and a greater likelihood of response than belimumab. ⁂ MPAA may be preferable over Azathioprine § Alternative agents such as leflunomide are occasionally used for those with arthritis ‖ Evidence for severe neurologic syndromes was largely limited to IV CYC
November 3, 2025 at 4:35 PM
micha.thehangrystories.com
Gut, dass wir morgen den nocht verschiebbaren Ccle Train gebucht haben. #Regenjacke
May 29, 2025 at 9:50 PM
cclermont.bsky.social
@mark-carney.bsky.social Please help stop this.
bsky.app/profile/ccle...
August 13, 2025 at 11:42 PM
wwhglobaled.bsky.social
3️⃣ Effective evidence use depends on policy alignment, partner coordination, and strong government partnerships. #CCLE #EvidenceUse
October 13, 2025 at 4:49 PM
ccleub.bsky.social
🎉 Benvinguts i benvingudes al nou perfil de Bluesky del grup CCLE!
📢 A partir d’ara, compartirem totes les novetats i notícies aquí.
❌ La UB ha decidit abandonar X, i la compte @CCLEUB queda inactiva.
Gràcies per seguir-nos en aquesta nova etapa! 💙 #Bluesky @geografiaub.bsky.social
December 3, 2024 at 9:31 AM
wwhglobaled.bsky.social
The 5th Cross-Country Learning Exchange (#CCLE) in Nairobi has been off to an energetic, collaborative and inspiring start! The event is jointly organised by @poverty-action.bsky.social, @wwhglobaled.bsky.social and Kenya's Ministry of Education.
October 13, 2025 at 4:49 PM
vrendo.bsky.social
3/ The expression of these collaterally altered genes should scale with their copy number. However, by integrating data from >8000 tumors in TCGA & CCLE, we identify amplified genes that are consistently expressed at lower levels than expected, and term them “compensated genes”.
January 27, 2025 at 10:07 PM
shinkicker13.bsky.social
Plus: our podcast is now LIVE on YouTube! We’re recording + streaming episodes at the same time. Like, subscribe, and tell a friend- it’s free & helps us grow 🙌
🔗 www.youtube.com/watch?v=CClE...
Welcome to our live show!
YouTube video by Royal Riot
www.youtube.com
September 11, 2025 at 7:01 PM
magicsherep.bsky.social
CCLE bridge is such a waste of money. Every time I fly over there are no vehicles on it. The roads on the Mactan are so small and congested that it doesn’t save anytime for anyone going to the airport from the south of cebu. They should have built the roads that would have made the bridge useful
October 25, 2024 at 8:27 AM
chielie.bsky.social
www.theguardian.com/world/2025/a...

Goeie bandnaam zeg, 'Moose migration'.

(Tnx Wup en CCLE)
April 16, 2025 at 11:57 AM
cclemon99.bsky.social
It was that long ago that I said this about Premium Bandai. But the new Dino Buckler may be taking the crown. Mostly because it is righting many, many wrongs.

bsky.app/profile/ccle...
cclemon99.bsky.social CCLemon99 @cclemon99.bsky.social · Apr 16
Still my favorite Premium Bandai release. Can’t recommend it enough.
April 29, 2025 at 12:16 AM
judith-bernett.bsky.social
🧵8/10 Further, models trained on CTRPv2 (largest dataset) generalize weakly to CTRPv1 and CCLE.
Our ablation study shows that multi-modal models ignore most of their input and focus on drug identities instead.
Pearson Correlation of model predictions vs. ground truth lnIC50 values for various models. All models are trained on CTRPv2 and tested on unseen cell lines (LCO) of CTRPv2, CTRPv1 and CCLE. The image shows a notable performance decrease when generalizing to other datasets. Mean ablation study results of the Multi-omics Random Forest and DIPK. One omics input is randomized at a time, such that a drug/cell line receives a random feature of another drug/cell line. Models are retrained from scratch with the randomized features. The R2 of the unperturbed models are subtracted from the R2 of the ablated models for each cross-validation fold: negative values indicate that the perturbation decreased model performance. Permutation mostly did not have any impact, the only visibly strong impact is the MolGNet drug features for DIPK and the drug fingerprints for the Multi Omics Random Forest.
June 3, 2025 at 1:41 PM
wwhglobaled.bsky.social
Day 1 of the Cross-Country Learning Exchange (CCLE) kicks off in Nairobi 🇰🇪 !

EdLab teams, government partners & researchers are exploring how data & evidence can transform education policy and improve learning outcomes.

Stay tuned for more.

#EmbeddedEvidenceLabs #EdLab
October 13, 2025 at 10:33 AM
jackscellphone.bsky.social
Compare, contrast👍
The Cleveland Guardians record since September 5, 2025 with text as follows: C Home Stats Schedule Fri, 9/5 @TB TB W 7-1 Sat, 9/6 @TB TB W 3-2 Sun, 9/7 @TB TB W 2-1 Mon, 9/8 vs KC KC W 10-2 Tue, 9/9 VS KC KC W 2-0 Wed, 9/10 vs KC KC L 4-3 Thu, 9/11 VS KC KC W 3-2 Fri, 9/12 vs CHW W 4-0 Sat, 9/13 VSCHW W 3-1 Sun, 9/14 vs CHW W 3-2 Tue, 9/16 @DET W 7-5 F/10 Wed, 9/17DET W 4-0 Thu, 9/18 @DET W 3-1 Fri, 9/19 MIN W 6-2 Sat, 9/20 @MIN W 6-0 Sat, 9/20 MIN W 8-0 Sun, 9/21 @MIN L 6-2 Tue, 9/23 VS DET W 5-2 Wed, 9/24 VS DET W 5-1 Thu, 9/25 VS DET L 4-2 Fri, 9/26 VST TEX L 7-3 Sat, 9/27 vs T TEX W 3-2 DATE OPPONENT TIME Sun, 9/28 vs T TEX 3:10 PM The Detroit Tigers record since September 5, 2025 with text as follows: \Home Stats Schedule Fri, 9/5 VS છ CHW L 7-5 Sat, 9/6 vs CHW W 6-0 Sun, 9/7 VS CHW L 6-4 Tue, 9/9 @NYY W 12-2 Wed, 9/10 @ NYY W 11-1 Thu, 9/11 @NYY L 9-3 Fri, 9/12 @M ΜΙΑ L 8-2 Sat, 9/13 @MMIA L 6-4 F/11 Sun, 9/14 @M ΜΙΑ W 2-0 Tue, 9/16 VS C CLE L 7-5 F/10 Wed, 9/17 VS C CLE L 4-0 Thu, 9/18 VS C CLE L 3-1 Fri, 9/19 vs ATL L 10-1 Sat, 9/20 vs ATL L 6-5 Sun, 9/21 vs A ATL L 6-2 Tue, 9/23 @ C CLE L 5-2 Wed, 9/24 @CCLE L 5-1 Thu, 9/25 @ C CLE W 4-2 Fri, 9/26 @ B BOS L 4-3 Sat, 9/27 @ B BOS W 2-1 DATE OPPONENT TIME Sun, 9/28 @ B BOS 3:05 PM
September 28, 2025 at 2:10 AM
cnbusinessforum.bsky.social
[TRADE SHOW] 2024 China Campus Logistics Exhibition (CCLE), taking place from October 31 to November 2, 2024, at the Western China International Expo Center in Chengdu, Sichuan Province, China.
2024 China Campus Logistics Exhibition (CCLE): Campus Solutions &
Join the 8th China Campus Logistics Exhibition (CCLE) from October 31 to November 2, 2024, in Chengdu. Explore the latest innovations in campus management, smart safety, energy solutions, and
cnbusinessforum.com
October 6, 2024 at 10:54 AM
zhongbok.bsky.social
Our teaching platform will be changed from @ccle to Bruin Learn, UCLA's new learning management system built on Canvas starting Winter 2022. Listening to the presentation and tutorial given at our regular faculty meeting now.
November 22, 2024 at 1:53 AM
andeanpuppy.bsky.social
Maybe even worse. Right in our faces, a Mumsnet dweller.

bsky.app/profile/ccle...
January 26, 2024 at 4:57 PM
ha-0-ku.bsky.social
#シブアニ で桜と杉下のキャラソンのこと話されてたけど、マジで視聴しといて良かった。

あと3日間？ほど無料配信してるので是非とも視聴して欲しい。

桜&杉下の【S-MASH UP (スマッシュアップ)】最高にエモいんで。
デュエットではなく“歌での対話”が聴いてなるほど、って思った。

SHIBUYA ANIME BASE #10
abema.app/ccLE
July 2, 2024 at 9:20 AM
deannachurch.bsky.social
AR: Can infer some CNV using RNA-seq using CCLE cell lines as test. #gi2015
November 3, 2024 at 8:14 AM
dzmitrybio.bsky.social
The article redefines SLC25A38 as a mitochondrial pyridoxal phosphate (PLP, “active” vitamin B6) transporter important at low PLP concentrations.

While working on glycine oxidation, the lack of association with GCS expression in CCLE was puzzling. Problem solved. Ty

www.nature.com/articles/s41...
SLC25A38 is required for mitochondrial pyridoxal 5’-phosphate (PLP) accumulation - Nature Communications
Pyridoxal 5’-phosphate (PLP, vitamin B6) is crucial for various metabolic processes. Here, the authors identified SLC25A38 as a key regulator of mitochondrial PLP levels using a genome-wide CRISPRi sc...
www.nature.com
January 28, 2025 at 12:27 PM
cellosaurus.bsky.social
Concern 375 of the CCLE panel: Quantitative Proteomics of the Cancer Cell Line Encyclopedia https://www.cell.com/cell/fulltext/S0092-8674(19)31385-6#.Xix2GImHXQx.twitter
January 21, 2025 at 5:36 PM
bluepearlmoon.bsky.social
Caleb and Raf may have pushed him to third but I do still adore him!!! if I could afford it I'd have 3 mains

I ccle through loving them, I'll probably have a Xav phase again as soon as I'm done yelling over Caleb lkjhgfd
March 26, 2025 at 3:34 AM
explicit758.bsky.social
Cleanna (Ccle Ccle on Instagram)
#Slu758 #SaintLucia #Slu #ebony #pyt #freak #stlucia #stlucian #saintlucian
July 1, 2025 at 12:20 PM
wwhglobaled.bsky.social
The 5th annual Cross-Country Learning Exchange (CCLE) kicks off soon in Nairobi, Kenya 🇰🇪.

Co-hosted by @poverty-action.bsky.social, @wwhglobaled.bsky.social and the Ministry of Education of Kenya, this 3-day gathering will bring together policymakers, researchers, funders and #EdLab teams 🌍.
IPA Embedded Evidence Lab Program | IPA
bit.ly
October 9, 2025 at 2:09 PM
meikefischer.bsky.social
I ccle a lot but never on snow. Thats the worst
December 20, 2024 at 1:52 PM