Previous infection with a common childhood virus could carry clues about lifelong health.
A recent Nature paper describes a novel method used to analyze genetic and health data from 750,000 people, including 245,000 AllofUsResearch program participants, to learn why some people develop certain

Measuring the accuracy of electronic health record (EHR)-based phenotyping in the All of Us Research Program to optimize statistical power for genetic association testing
Baierl, J. D., Hsiao et al.
Paper
Details
#EHRPhenotyping #GeneticAssociation #AllOfUsResearch

2/10 We then conducted #pharmacogenetic GWAS and rare variant burden tests. Discovery GWAS were conducted in the @ukbiobank.bsky.social and replication analyses in the #AllOfUSResearch. We don’t discover any new pharmacogenetic signals, but also don’t miss any major signal reported previously.

www.biorxiv.org/content/10.1...
📄 New preprint alert! 📄
@helenyslin.bsky.social benchmarked polygenic scores (PGS) using genotyping arrays vs whole-genome sequencing (WGS) across traits & populations in @AllofUsResearch. What’s the best approach? The answer is… it depends! 🧵⬇️

Researchers looked at @AllofUsResearch data to see how type 2 diabetes could affect a person's health over time. They found 8 subgroups of type 2 diabetes, each with its own genetic patterns.

Read more: http://allof-us.org/DNApatterns #AllofUsInclusion #JoinAllofUs

Calling all researchers! Have you seen any #CallForPapers on
#AllofUsResearch
or #MigraineResearch? Drop any leads here! #Neuroscience #HealthResearch
@amfmigraine.bsky.social
Thanks!

The GTEx V10 has been released. Compared to release V8, V10 has 12% more RNA-seq samples and 23% more samples used for eQTL analyses. V10 release includes new smallRNA-seq data from 16,760 tissue samples, including gene expression counts and cis-QTLs: buff.ly/4eMQb1V
#UKBiobank #AllofUsResearch

A phenome-wide association study of methylated GC-rich repeats identifies a GCC repeat expansion in AFF3 associated with intellectual disability - Nature Genetics

#UKBiobank #AllofUsResearch #GenomicsEngland

New study reveals ATRNL1's key role in atrial fibrillation. Using single-nuclei RNA-seq, researchers identified its impact on cardiac conduction. Could ATRNL1 be the next therapeutic target for AF? doi.org/10.1038/s414...
#genetics #AF #UKBiobank #AllofUsResearch #GenomicsEngland #scRNAseq

👉 Out now @NatureRevGenet: we CAN and we SHOULD do more to enable #genomic data sharing! 🧬🌏

👉Best practice examples and 12 actions we can all take together

👉 https://rdcu.be/dWfsu

@GA4GH @AusGenomics @GenomicsEngland @NHSgms @AllofUsResearch @uk_biobank @ukfuturehealth

Great panel discussion on creative and inclusive approach being used by @AllofUsResearch Geoff Ginsberg @PersonalizedMed #aspenhealthideas

Great panel discussion on creative and inclusive approach being used by @AllofUsResearch Geoff Ginsberg @PersonalizedMed #aspenhealthideas

Now for highlights session @eshg2024 @konradjk and @AllofUsResearch dataset!

I asked ChatGpt4 if one can trust UMAP clusters when experimental validation is not possible (that would be the Nature paper AllofUsResearch under discussion). My non-nuanced answer based on its nuanced answer is NO

Genomics, race, & ethics clean-up in aisle..or figures 1-5. #AllOfUSResearch #ScientificMisconduct

Human genomic researchers need to stop using biased methods (population sampling, racial/ethnicity definitions, & problematic statistical models like UMAP) to misrepresent human diversity.

Eisen: "This paper from @AllofUsResearch needs to be retracted by @nature immediately. Under pretext of inclusivity it features a scientifically invalid representation of genetic diversity and race that is going to feature in racist literature for decades."

So exciting to see such a diverse cohort of data being made available to researchers. Congrats to the entire @AllofUsResearch team. https://x.com/AndreaRamirezMD/status/1268198971421478912

It takes ~17yrs for research to be implemented in practice. Can we do better #Genomics? @GA4GH @AusGenomics @GenomicsEngland @AllofUsResearch @genome_gov