[BioRxiv] RNA modulates FUS condensate assembly, dynamics, and aggregation through diverse molecular contacts
https://doi.org/10.64898/2025.12.13.694118
#neurodegeneration #biorxiv #phaseseparation #RNAbindingprotein #aggregate
https://doi.org/10.64898/2025.12.13.694118
#neurodegeneration #biorxiv #phaseseparation #RNAbindingprotein #aggregate
BioRxiv Article
doi.org
December 16, 2025 at 4:25 AM
[BioRxiv] RNA modulates FUS condensate assembly, dynamics, and aggregation through diverse molecular contacts
https://doi.org/10.64898/2025.12.13.694118
#neurodegeneration #biorxiv #phaseseparation #RNAbindingprotein #aggregate
https://doi.org/10.64898/2025.12.13.694118
#neurodegeneration #biorxiv #phaseseparation #RNAbindingprotein #aggregate
[BioRxiv] Phase Behavior of TDP-43 and hnRNP H1: From Soluble and Aggregated States to Liquid-Like Droplets
https://doi.org/10.1101/2025.11.12.687994
#neurodegeneration #biorxiv #phaseseparation #aggregate
https://doi.org/10.1101/2025.11.12.687994
#neurodegeneration #biorxiv #phaseseparation #aggregate
BioRxiv Article
doi.org
December 16, 2025 at 4:22 AM
[BioRxiv] Phase Behavior of TDP-43 and hnRNP H1: From Soluble and Aggregated States to Liquid-Like Droplets
https://doi.org/10.1101/2025.11.12.687994
#neurodegeneration #biorxiv #phaseseparation #aggregate
https://doi.org/10.1101/2025.11.12.687994
#neurodegeneration #biorxiv #phaseseparation #aggregate
Grateful to present at the BMB Research Colloquium @ Johns Hopkins!
Shared our work on how transient PAR signals trigger sustained FUS condensation — revealing molecular hysteresis in DNA repair foci.
Always excited to share science in person.
#BiomolecularCondensates #DNARepair #PhaseSeparation
Shared our work on how transient PAR signals trigger sustained FUS condensation — revealing molecular hysteresis in DNA repair foci.
Always excited to share science in person.
#BiomolecularCondensates #DNARepair #PhaseSeparation
December 14, 2025 at 9:12 PM
Grateful to present at the BMB Research Colloquium @ Johns Hopkins!
Shared our work on how transient PAR signals trigger sustained FUS condensation — revealing molecular hysteresis in DNA repair foci.
Always excited to share science in person.
#BiomolecularCondensates #DNARepair #PhaseSeparation
Shared our work on how transient PAR signals trigger sustained FUS condensation — revealing molecular hysteresis in DNA repair foci.
Always excited to share science in person.
#BiomolecularCondensates #DNARepair #PhaseSeparation
“The work of McKnight and Görlich is a testament to curiosity-driven research.”
#ICYMI: William G. Kaelin Jr writes about this year’s Basic Research #LaskerAward winners in the @pnas.org #Lasker2025 collection. 🧪
www.pnas.org/doi/10.1073/...
@mpi-nat.bsky.social
#phaseseparation #biophysics
#ICYMI: William G. Kaelin Jr writes about this year’s Basic Research #LaskerAward winners in the @pnas.org #Lasker2025 collection. 🧪
www.pnas.org/doi/10.1073/...
@mpi-nat.bsky.social
#phaseseparation #biophysics
Making sense of low-complexity domains: The 2025 Lasker Basic Science Award | PNAS
Up to 10 to 20% of the proteome contains regions with much lower amino acid diversity than would be expected by chance. This year’s Lasker Basic Sc...
www.pnas.org
December 9, 2025 at 8:45 PM
“The work of McKnight and Görlich is a testament to curiosity-driven research.”
#ICYMI: William G. Kaelin Jr writes about this year’s Basic Research #LaskerAward winners in the @pnas.org #Lasker2025 collection. 🧪
www.pnas.org/doi/10.1073/...
@mpi-nat.bsky.social
#phaseseparation #biophysics
#ICYMI: William G. Kaelin Jr writes about this year’s Basic Research #LaskerAward winners in the @pnas.org #Lasker2025 collection. 🧪
www.pnas.org/doi/10.1073/...
@mpi-nat.bsky.social
#phaseseparation #biophysics
[BioRxiv] Phase separation as a concentrating mechanism of protein/peptide hormones for the secretory granule storage
https://doi.org/10.64898/2025.12.05.692483
#neurodegeneration #biorxiv #phaseseparation #amyloid
https://doi.org/10.64898/2025.12.05.692483
#neurodegeneration #biorxiv #phaseseparation #amyloid
BioRxiv Article
doi.org
December 9, 2025 at 6:25 PM
[BioRxiv] Phase separation as a concentrating mechanism of protein/peptide hormones for the secretory granule storage
https://doi.org/10.64898/2025.12.05.692483
#neurodegeneration #biorxiv #phaseseparation #amyloid
https://doi.org/10.64898/2025.12.05.692483
#neurodegeneration #biorxiv #phaseseparation #amyloid
I’ll be presenting at this week’s BMB Research Colloquium on how PAR triggers sustained FUS condensation (hysteresis) in DNA repair.
📍 JHSPH W3030
🕥 Thu, Dec 11 | 10:30 AM
All welcome!
Poster credit: Maranda
#DNARepair #PhaseSeparation #BiomolecularCondensates #PAR #FUS #Science
📍 JHSPH W3030
🕥 Thu, Dec 11 | 10:30 AM
All welcome!
Poster credit: Maranda
#DNARepair #PhaseSeparation #BiomolecularCondensates #PAR #FUS #Science
December 6, 2025 at 1:55 AM
I’ll be presenting at this week’s BMB Research Colloquium on how PAR triggers sustained FUS condensation (hysteresis) in DNA repair.
📍 JHSPH W3030
🕥 Thu, Dec 11 | 10:30 AM
All welcome!
Poster credit: Maranda
#DNARepair #PhaseSeparation #BiomolecularCondensates #PAR #FUS #Science
📍 JHSPH W3030
🕥 Thu, Dec 11 | 10:30 AM
All welcome!
Poster credit: Maranda
#DNARepair #PhaseSeparation #BiomolecularCondensates #PAR #FUS #Science
November 30, 2025 at 8:57 AM
I've had to write about #PhaseSeparation atleast four times now, but I'll be damned if I can make heads or tales of this topic. @philipcball.bsky.social FYI might want to keep an eye on Andrea's thread.
November 29, 2025 at 6:05 PM
I've had to write about #PhaseSeparation atleast four times now, but I'll be damned if I can make heads or tales of this topic. @philipcball.bsky.social FYI might want to keep an eye on Andrea's thread.
🌟G&D SPOTLIGHT 🌟
REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract
#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates
REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract
#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates
November 28, 2025 at 7:00 PM
🌟G&D SPOTLIGHT 🌟
REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract
#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates
REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract
#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates
Why are low-complexity domains (LCDs) in proteins important?
#LaskerAward winners Dirk Görlich & Steven McKnight showed that they are critical for intracellular transport and organization. #Lasker2025 🧪
#structuralbiology #phaseseparation
@mpi-nat.bsky.social
#LaskerAward winners Dirk Görlich & Steven McKnight showed that they are critical for intracellular transport and organization. #Lasker2025 🧪
#structuralbiology #phaseseparation
@mpi-nat.bsky.social
Low-complexity domains: structures & functions
The 2025 Albert Lasker Basic Medical Research Award honors Dirk Görlich and Steven McKnight for discoveries that exposed the structures and functions of low-complexity domains within protein…
www.youtube.com
November 28, 2025 at 1:45 PM
Why are low-complexity domains (LCDs) in proteins important?
#LaskerAward winners Dirk Görlich & Steven McKnight showed that they are critical for intracellular transport and organization. #Lasker2025 🧪
#structuralbiology #phaseseparation
@mpi-nat.bsky.social
#LaskerAward winners Dirk Görlich & Steven McKnight showed that they are critical for intracellular transport and organization. #Lasker2025 🧪
#structuralbiology #phaseseparation
@mpi-nat.bsky.social
☕Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones that in turn enhance folding of #proinsulin. #PhaseSeparation
bit.ly/44mX1bW
bit.ly/44mX1bW
Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding - Nature Cell Biology
Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones t...
bit.ly
November 27, 2025 at 9:31 AM
☕Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones that in turn enhance folding of #proinsulin. #PhaseSeparation
bit.ly/44mX1bW
bit.ly/44mX1bW
🌟G&D SPOTLIGHT 🌟
RESEARCH PAPER: Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions
By Bonneau et al. and Elena Conti
➡️ https://genesdev.cshlp.org/content/37/11-12/505.abstract
#ribonucleoproteins #granules #RNAinteractions #IDR #phaseseparation
RESEARCH PAPER: Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions
By Bonneau et al. and Elena Conti
➡️ https://genesdev.cshlp.org/content/37/11-12/505.abstract
#ribonucleoproteins #granules #RNAinteractions #IDR #phaseseparation
November 26, 2025 at 4:01 PM
🌟G&D SPOTLIGHT 🌟
RESEARCH PAPER: Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions
By Bonneau et al. and Elena Conti
➡️ https://genesdev.cshlp.org/content/37/11-12/505.abstract
#ribonucleoproteins #granules #RNAinteractions #IDR #phaseseparation
RESEARCH PAPER: Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions
By Bonneau et al. and Elena Conti
➡️ https://genesdev.cshlp.org/content/37/11-12/505.abstract
#ribonucleoproteins #granules #RNAinteractions #IDR #phaseseparation
Online now - the Review " #Autophagy regulation by phase separation, avidity, and wetting" from @wilflinglab.bsky.social, @kraftlabfr.bsky.social and co.
#BiomolecularCondensates #PhaseSeparation #Wetting #Avidity #Theraeputics
Read it here: authors.elsevier.com/sd/article/S...
#BiomolecularCondensates #PhaseSeparation #Wetting #Avidity #Theraeputics
Read it here: authors.elsevier.com/sd/article/S...
November 21, 2025 at 5:54 PM
Online now - the Review " #Autophagy regulation by phase separation, avidity, and wetting" from @wilflinglab.bsky.social, @kraftlabfr.bsky.social and co.
#BiomolecularCondensates #PhaseSeparation #Wetting #Avidity #Theraeputics
Read it here: authors.elsevier.com/sd/article/S...
#BiomolecularCondensates #PhaseSeparation #Wetting #Avidity #Theraeputics
Read it here: authors.elsevier.com/sd/article/S...
👋Our November issue's out!
Cover: Electrostatic forces in condensates
👉🏼Comments: #DEI; #statistics #CellBiology; german #StemCell network
🔬 #ferroptosis #mitochondria #PhaseSeparation #EmbryoModels #transcriptomics #chromatin #cancer #TransposableElements & more!
www.nature.com/ncb/volumes/...
Cover: Electrostatic forces in condensates
👉🏼Comments: #DEI; #statistics #CellBiology; german #StemCell network
🔬 #ferroptosis #mitochondria #PhaseSeparation #EmbryoModels #transcriptomics #chromatin #cancer #TransposableElements & more!
www.nature.com/ncb/volumes/...
November 14, 2025 at 8:07 PM
👋Our November issue's out!
Cover: Electrostatic forces in condensates
👉🏼Comments: #DEI; #statistics #CellBiology; german #StemCell network
🔬 #ferroptosis #mitochondria #PhaseSeparation #EmbryoModels #transcriptomics #chromatin #cancer #TransposableElements & more!
www.nature.com/ncb/volumes/...
Cover: Electrostatic forces in condensates
👉🏼Comments: #DEI; #statistics #CellBiology; german #StemCell network
🔬 #ferroptosis #mitochondria #PhaseSeparation #EmbryoModels #transcriptomics #chromatin #cancer #TransposableElements & more!
www.nature.com/ncb/volumes/...
“The Enigma of Protein Domains of Low-Sequence Complexity”
#LaskerAward winner S. McKnight writes about “these ugly duckling proteins” that turned out to be vital for cellular function. 🧪
#RNAbiology #phaseseparation #Lasker2025 #UTSWMedicalCenter #JAMA
ow.ly/klVz50WY5Hf
#LaskerAward winner S. McKnight writes about “these ugly duckling proteins” that turned out to be vital for cellular function. 🧪
#RNAbiology #phaseseparation #Lasker2025 #UTSWMedicalCenter #JAMA
ow.ly/klVz50WY5Hf
November 11, 2025 at 5:17 PM
“The Enigma of Protein Domains of Low-Sequence Complexity”
#LaskerAward winner S. McKnight writes about “these ugly duckling proteins” that turned out to be vital for cellular function. 🧪
#RNAbiology #phaseseparation #Lasker2025 #UTSWMedicalCenter #JAMA
ow.ly/klVz50WY5Hf
#LaskerAward winner S. McKnight writes about “these ugly duckling proteins” that turned out to be vital for cellular function. 🧪
#RNAbiology #phaseseparation #Lasker2025 #UTSWMedicalCenter #JAMA
ow.ly/klVz50WY5Hf
#Review
Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets doi.org/10.1186/s435...
#PhaseSeparation #BiomolecularCondensate #NuclearSpeckle #Paraspeckle #StressGranule
Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets doi.org/10.1186/s435...
#PhaseSeparation #BiomolecularCondensate #NuclearSpeckle #Paraspeckle #StressGranule
Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets - Molecular Biomedicine
Cells constantly encounter environmental and physiological fluctuations that challenge homeostasis and threaten viability. In response to these cues, specific proteins and nucleic acids engage in mult...
doi.org
November 7, 2025 at 8:45 AM
#Review
Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets doi.org/10.1186/s435...
#PhaseSeparation #BiomolecularCondensate #NuclearSpeckle #Paraspeckle #StressGranule
Biomolecular condensates: molecular structure, biological functions, diseases, and therapeutic targets doi.org/10.1186/s435...
#PhaseSeparation #BiomolecularCondensate #NuclearSpeckle #Paraspeckle #StressGranule
☕Li, Burgos-Bravo et al. report that NDF #PhaseSeparation regulates FACT condensation, which enhances transcription by generating a localized biochemical environment that promotes nucleosome disassembly while preserving #chromatin integrity by retaining histones.
bit.ly/3JwVetO
bit.ly/3JwVetO
Phase-separated NDF−FACT condensates facilitate transcription elongation on chromatin - Nature Cell Biology
Li, Burgos-Bravo and colleagues report that NDF phase separation regulates FACT condensation, which enhances transcription by generating a localized biochemical environment that promotes nucleosome di...
bit.ly
November 4, 2025 at 6:22 PM
☕Li, Burgos-Bravo et al. report that NDF #PhaseSeparation regulates FACT condensation, which enhances transcription by generating a localized biochemical environment that promotes nucleosome disassembly while preserving #chromatin integrity by retaining histones.
bit.ly/3JwVetO
bit.ly/3JwVetO
Bacteria use paralog teamwork to survive stress.
H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure.
#PhaseSeparation #Bacteria
www.biorxiv.org/content/10.1...
H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure.
#PhaseSeparation #Bacteria
www.biorxiv.org/content/10.1...
Paralogs with distinct phase behaviors broaden the in vivo stress response range of condensates
Paralogs are widespread, but their physiological roles are often masked by redundancy. H-NS, a nucleoid-associated protein in Gram-negative bacteria, typically coexists with paralogs such as StpA, who...
www.biorxiv.org
October 20, 2025 at 7:55 PM
Bacteria use paralog teamwork to survive stress.
H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure.
#PhaseSeparation #Bacteria
www.biorxiv.org/content/10.1...
H-NS forms fluid condensates; its partner StpA forms rigid fibrils. Together, they balance flexibility & stability to keep genes properly regulated under pressure.
#PhaseSeparation #Bacteria
www.biorxiv.org/content/10.1...
Epitranscriptomics #PhaseSeparation
m6A-modified #EnhancerRNA & YTHDC1-BRD4 assemble transcriptional condensate
MINT-seq detects >3-fold more m6A peaks than MeRIP-seq
Stringtie annotate eRNAs & promoter upstream antisense RNAs, 24% & 48% are m6A+ (MCF7)
#MolCell 2021
www.cell.com/molecular-ce...
m6A-modified #EnhancerRNA & YTHDC1-BRD4 assemble transcriptional condensate
MINT-seq detects >3-fold more m6A peaks than MeRIP-seq
Stringtie annotate eRNAs & promoter upstream antisense RNAs, 24% & 48% are m6A+ (MCF7)
#MolCell 2021
www.cell.com/molecular-ce...
October 19, 2025 at 7:12 PM
Epitranscriptomics #PhaseSeparation
m6A-modified #EnhancerRNA & YTHDC1-BRD4 assemble transcriptional condensate
MINT-seq detects >3-fold more m6A peaks than MeRIP-seq
Stringtie annotate eRNAs & promoter upstream antisense RNAs, 24% & 48% are m6A+ (MCF7)
#MolCell 2021
www.cell.com/molecular-ce...
m6A-modified #EnhancerRNA & YTHDC1-BRD4 assemble transcriptional condensate
MINT-seq detects >3-fold more m6A peaks than MeRIP-seq
Stringtie annotate eRNAs & promoter upstream antisense RNAs, 24% & 48% are m6A+ (MCF7)
#MolCell 2021
www.cell.com/molecular-ce...
🎃Our October issue's out!
Cover: mechanoresponsive #microtubules
👉🏼Reviews: #CellularStress ; #NuclearPoreComplex & #mechanobiology
🔬 #StemCells #senescence #cancer #EndoplasmicReticulum #phagocytosis #pyroptosis #autophagy #PhaseSeparation #AMPK #chromatin & more!
www.nature.com/ncb/volumes/...
Cover: mechanoresponsive #microtubules
👉🏼Reviews: #CellularStress ; #NuclearPoreComplex & #mechanobiology
🔬 #StemCells #senescence #cancer #EndoplasmicReticulum #phagocytosis #pyroptosis #autophagy #PhaseSeparation #AMPK #chromatin & more!
www.nature.com/ncb/volumes/...
October 17, 2025 at 10:25 AM
🎃Our October issue's out!
Cover: mechanoresponsive #microtubules
👉🏼Reviews: #CellularStress ; #NuclearPoreComplex & #mechanobiology
🔬 #StemCells #senescence #cancer #EndoplasmicReticulum #phagocytosis #pyroptosis #autophagy #PhaseSeparation #AMPK #chromatin & more!
www.nature.com/ncb/volumes/...
Cover: mechanoresponsive #microtubules
👉🏼Reviews: #CellularStress ; #NuclearPoreComplex & #mechanobiology
🔬 #StemCells #senescence #cancer #EndoplasmicReticulum #phagocytosis #pyroptosis #autophagy #PhaseSeparation #AMPK #chromatin & more!
www.nature.com/ncb/volumes/...
The KEY🔑 to regulating Rubisco phase separation in the Chlamydomonas algal pyrenoid. Beautiful work by Shan He, @mjonikas.bsky.social, and friends. #PhaseSeparation #CO2 #PlantScience 🧪 🧶🧬 🌾 🌍
Algal pyrenoids—condensates that mediate ~1/3 of Earth’s CO2 fixation—change size and number as cells divide. Our data suggest a simple control mechanism: a kinase that continuously ejects material from the condensate! ☀️🌍🔬💧 #Biophysics #Photosynthesis
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
October 12, 2025 at 9:26 PM
The KEY🔑 to regulating Rubisco phase separation in the Chlamydomonas algal pyrenoid. Beautiful work by Shan He, @mjonikas.bsky.social, and friends. #PhaseSeparation #CO2 #PlantScience 🧪 🧶🧬 🌾 🌍
🚨 Publication🚨: ACS Nano: @laynefrechette.bsky.social
and @n4rens.bsky.social use Langevin dynamics simulations to demonstrate how self-assembly of empty #ViralCapsidAssembly is modulated by liquid compartments formed by #PhaseSeparation. Check it out: pubs.acs.org/doi/10.1021/... #BrandeisMRSEC
and @n4rens.bsky.social use Langevin dynamics simulations to demonstrate how self-assembly of empty #ViralCapsidAssembly is modulated by liquid compartments formed by #PhaseSeparation. Check it out: pubs.acs.org/doi/10.1021/... #BrandeisMRSEC
October 11, 2025 at 4:20 PM
🚨 Publication🚨: ACS Nano: @laynefrechette.bsky.social
and @n4rens.bsky.social use Langevin dynamics simulations to demonstrate how self-assembly of empty #ViralCapsidAssembly is modulated by liquid compartments formed by #PhaseSeparation. Check it out: pubs.acs.org/doi/10.1021/... #BrandeisMRSEC
and @n4rens.bsky.social use Langevin dynamics simulations to demonstrate how self-assembly of empty #ViralCapsidAssembly is modulated by liquid compartments formed by #PhaseSeparation. Check it out: pubs.acs.org/doi/10.1021/... #BrandeisMRSEC
🚨 Publication Alert 🚨
Congratulations to Weixiang Chen from @waltherlab.bsky.social Andreas Walther Lab on their recent publication in #NatureCommunications! 🎉👏
#SyntheticNuclearArchitectures #TranscriptionalCondensates #DNAProtonucleus #BiomolecularCondensates #PhaseSeparation #SFB1551 #UniMainz
Congratulations to Weixiang Chen from @waltherlab.bsky.social Andreas Walther Lab on their recent publication in #NatureCommunications! 🎉👏
#SyntheticNuclearArchitectures #TranscriptionalCondensates #DNAProtonucleus #BiomolecularCondensates #PhaseSeparation #SFB1551 #UniMainz
🚨Miao's and Weixiang's work on RNA transcription in DNA based condensates as nucleus mimics is now out in @natcomms.nature.com www.nature.com/articles/s41...
#syncell #DNA #condensate #LLPS.
Great work to understand transcription and LLPS in #crowded #viscoelastic environments @sfb1551.bsky.social
#syncell #DNA #condensate #LLPS.
Great work to understand transcription and LLPS in #crowded #viscoelastic environments @sfb1551.bsky.social
Constructing synthetic nuclear architectures via transcriptional condensates in a DNA protonucleus - Nature Communications
Nuclear biomolecular condensates are functional sub-compartments within the cell nucleus. Here, the authors develop a synthetic DNA protonucleus that enables RNA transcription and condensation into di...
www.nature.com
September 29, 2025 at 12:01 PM
🚨 Publication Alert 🚨
Congratulations to Weixiang Chen from @waltherlab.bsky.social Andreas Walther Lab on their recent publication in #NatureCommunications! 🎉👏
#SyntheticNuclearArchitectures #TranscriptionalCondensates #DNAProtonucleus #BiomolecularCondensates #PhaseSeparation #SFB1551 #UniMainz
Congratulations to Weixiang Chen from @waltherlab.bsky.social Andreas Walther Lab on their recent publication in #NatureCommunications! 🎉👏
#SyntheticNuclearArchitectures #TranscriptionalCondensates #DNAProtonucleus #BiomolecularCondensates #PhaseSeparation #SFB1551 #UniMainz
We also observed that PSII concentration was uniform throughout each granum, irrespective of distance from the margin. Thus, we propose a simple two-domain model of thylakoid organization in green algae and plants. And yes, we speculate about domain #PhaseSeparation. I await your hate mail 📬🤗
8/🧵
8/🧵
September 25, 2025 at 6:31 PM
We also observed that PSII concentration was uniform throughout each granum, irrespective of distance from the margin. Thus, we propose a simple two-domain model of thylakoid organization in green algae and plants. And yes, we speculate about domain #PhaseSeparation. I await your hate mail 📬🤗
8/🧵
8/🧵
💫NEW: Yin, Lin, Cai, Nie et al report #PhaseSeparation of ERCC6L2 as a mechanism that regulates RNF138-mediated ubiquitination and degradation of CtIP, thereby modulating DNA end resection and treatment response to ATM inhibitors in #cancer.
bit.ly/46H9p75
bit.ly/46H9p75
Phase separation of ERCC6L2–CtIP regulates the extent of DNA end resection - Nature Cell Biology
Yin, Lin, Cai, Nie and colleagues report phase separation of ERCC6L2 as a mechanism that regulates RNF138-mediated ubiquitination and degradation of CtIP, thereby modulating DNA end resection and treatment response to ATM inhibitors in cancer.
bit.ly
September 24, 2025 at 6:30 AM
💫NEW: Yin, Lin, Cai, Nie et al report #PhaseSeparation of ERCC6L2 as a mechanism that regulates RNF138-mediated ubiquitination and degradation of CtIP, thereby modulating DNA end resection and treatment response to ATM inhibitors in #cancer.
bit.ly/46H9p75
bit.ly/46H9p75