And I say this as someone who is as UF and is inclined to support findings spearheaded from here.

This publication in Nature was fascinating: Cancer cells swap mutated mitochondria with tumor-infiltrating immune cells (TILs). Metabolism is the keystone of cancer immunotherapy, yet often overlooked. Could this mechanism provide clues to increasing patient response? www.nature.com/articles/s41...

We are going to need them because at this rate no one will be able to retire (or afford child care or health care or elder care or a house or a car or food).

So much winning!

Brokerage accounts *are* free. Kinda shot myself in the foot there.

The min balance on many basic checking accounts in $50-100. Opening a brokerage account is not free, and even fraction shares of SPDR or QQQ are available. What are you talking about?

At a population level, it would correlate. In terms of trying to establish an exposure-outcome relationship… 😬😬

Also, fwiw, “brain lesions” via spot MRI as a measure of dementia trajectory is… not great.

And yet its impact on hard endpoints in humans has been… underwhelming.

The working experiment is to see if selection of an UPF and its corresponding dopamine response in ventral striatum corresponds to adiposity and or ad libitum weight trajectory/food consumption.

Exciting times! Counting on you to keep leading the field.

@zknight.bsky.social ‘s work in this is probably the most informative in the pre-clinical space, but how that then translates into easy access UPFs in mice/rats and humans (and how to study) is what I want to make sure to study with precision.

And if it doesn’t translate, it’s important to know

My bias is viewing especially human obesity as having biopsychosocial elements, so whether intermediate-term signals mirror bite-to-bite impacts is something I still struggle with.

No argument, was just speaking on the work i and some collaborators are doing now. I’m trying to continue to equilibrate of persistent and reliable increases in rodents, regionality (ventral vs dorsal striatum vs orbitofrontal can represent some meaningfully different neurocircuitry).

Now I’m wondering if we should modify to look at dopamine over much longer timescales? Is this better reflective of chronic dopamine dynamics between individuals? Or does it just not translate from rodents to humans?

Great work by you and your team (shoutout Dr. Darcey).

It clarifies but also raises some questions. In pre-clinical models, we do see some variance in ventral striatal dopamine response to palatable food, but its moment-to-moment measures.