@yysquare.bsky.social
great opportunity for those interested in how cancer affects the nerve and vice versa!
October 22, 2025 at 1:13 AM
great opportunity for those interested in how cancer affects the nerve and vice versa!
Reposted
When cancer invades nerves, inflammation pops off and causes pain! Ouch! 😬 Then, IL-6/IFNγ drives resistance to anti-PD-1 cancer treatment, lowers effectiveness 😱. The resistance was reversed by targeting nerve-injury signaling pathways. Critical discovery connecting #PainResearch to immunotherapy!
Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy - PubMed
Perineural invasion (PNI) is a well-established factor of poor prognosis in multiple cancer types<sup>1</sup>, yet its mechanism remains unclear. Here we provide clinical and mechanistic insights into...
pubmed.ncbi.nlm.nih.gov
October 8, 2025 at 5:10 PM
When cancer invades nerves, inflammation pops off and causes pain! Ouch! 😬 Then, IL-6/IFNγ drives resistance to anti-PD-1 cancer treatment, lowers effectiveness 😱. The resistance was reversed by targeting nerve-injury signaling pathways. Critical discovery connecting #PainResearch to immunotherapy!
Reposted
BOOM! www.nature.com/articles/s41... I think this is a big step forward for the field. Congrats to Lauren Donovan and @vivtawfik-mdphd.bsky.social and the whole Tawfik lab team.
Aging and injury drive neuronal senescence in the dorsal root ganglia - Nature Neuroscience
The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.
www.nature.com
May 14, 2025 at 1:53 PM
BOOM! www.nature.com/articles/s41... I think this is a big step forward for the field. Congrats to Lauren Donovan and @vivtawfik-mdphd.bsky.social and the whole Tawfik lab team.
Reposted
PRC Highlight: Congrats to PRC postdoc Jahedul Alam on his poster presentation on cancer pain at the Northeast Bioengineering Conference NEBEC 2025! Shout out to the Ye Lab #perineuralinvasion #mechanicalpain #stiffness @yylab.bsky.social @yysquare.bsky.social
engineering.nyu.edu/events/2025/...
engineering.nyu.edu/events/2025/...
April 11, 2025 at 4:51 PM
PRC Highlight: Congrats to PRC postdoc Jahedul Alam on his poster presentation on cancer pain at the Northeast Bioengineering Conference NEBEC 2025! Shout out to the Ye Lab #perineuralinvasion #mechanicalpain #stiffness @yylab.bsky.social @yysquare.bsky.social
engineering.nyu.edu/events/2025/...
engineering.nyu.edu/events/2025/...