Yuki Masuo M.D.
@yuki-masuo.bsky.social
PhD student | Ueno Lab | Kyoto University, Japan | Human immunology | Autoimmune diseases
Researchers at Chiba Univ identified HLF as a transcription factor of CD4 Trm, which is now published in @science.org 👍
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Hepatic leukemia factor directs tissue residency of proinflammatory memory CD4+ T cells
CD4+ tissue-resident memory T (TRM) cells contribute to host defense and to the pathogenesis of chronic inflammatory diseases, but the molecules that direct their differentiation are unknown. We found...
www.science.org
December 12, 2025 at 8:38 AM
Researchers at Chiba Univ identified HLF as a transcription factor of CD4 Trm, which is now published in @science.org 👍
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Yuki Masuo M.D.
🔬 Join us at the ASHBi Mini-Symposium
🧬 Decoding & Engineering the Human Immune System
📅 15 Dec · 10:30–17:00 (Kyoto Univ.)
✅ Registration still open!
👉 Sign up now: forms.gle/foCSeA3DHcyc...
🔗 Event details: ashbi.kyoto-u.ac.jp/event/event-...
#ASHBi #Immunology #HumanBiology
🧬 Decoding & Engineering the Human Immune System
📅 15 Dec · 10:30–17:00 (Kyoto Univ.)
✅ Registration still open!
👉 Sign up now: forms.gle/foCSeA3DHcyc...
🔗 Event details: ashbi.kyoto-u.ac.jp/event/event-...
#ASHBi #Immunology #HumanBiology
December 3, 2025 at 10:15 AM
🔬 Join us at the ASHBi Mini-Symposium
🧬 Decoding & Engineering the Human Immune System
📅 15 Dec · 10:30–17:00 (Kyoto Univ.)
✅ Registration still open!
👉 Sign up now: forms.gle/foCSeA3DHcyc...
🔗 Event details: ashbi.kyoto-u.ac.jp/event/event-...
#ASHBi #Immunology #HumanBiology
🧬 Decoding & Engineering the Human Immune System
📅 15 Dec · 10:30–17:00 (Kyoto Univ.)
✅ Registration still open!
👉 Sign up now: forms.gle/foCSeA3DHcyc...
🔗 Event details: ashbi.kyoto-u.ac.jp/event/event-...
#ASHBi #Immunology #HumanBiology
Our recent paper was highlighted in @natrevrheum.nature.com😊
Original paper: www.science.org/doi/10.1126/...
I forgot to mention this before, but I would like to thank @cnfogg.bsky.social & @hannah-isles.bsky.social for their smooth handling of our paper!
Original paper: www.science.org/doi/10.1126/...
I forgot to mention this before, but I would like to thank @cnfogg.bsky.social & @hannah-isles.bsky.social for their smooth handling of our paper!
September 5, 2025 at 2:11 PM
Our recent paper was highlighted in @natrevrheum.nature.com😊
Original paper: www.science.org/doi/10.1126/...
I forgot to mention this before, but I would like to thank @cnfogg.bsky.social & @hannah-isles.bsky.social for their smooth handling of our paper!
Original paper: www.science.org/doi/10.1126/...
I forgot to mention this before, but I would like to thank @cnfogg.bsky.social & @hannah-isles.bsky.social for their smooth handling of our paper!
📣Our new paper is out in Science Immunology.
We uncovered how stem-like and effector Tph cells play distinct roles in RA pathogenesis.
🔗https://www.science.org/doi/10.1126/sciimmunol.adt3955
Exciting illustration by @chimomonga.bsky.social depicting cells as robots and dogs🤖🐶
#RA
#Tph
We uncovered how stem-like and effector Tph cells play distinct roles in RA pathogenesis.
🔗https://www.science.org/doi/10.1126/sciimmunol.adt3955
Exciting illustration by @chimomonga.bsky.social depicting cells as robots and dogs🤖🐶
#RA
#Tph
August 16, 2025 at 12:06 AM
📣Our new paper is out in Science Immunology.
We uncovered how stem-like and effector Tph cells play distinct roles in RA pathogenesis.
🔗https://www.science.org/doi/10.1126/sciimmunol.adt3955
Exciting illustration by @chimomonga.bsky.social depicting cells as robots and dogs🤖🐶
#RA
#Tph
We uncovered how stem-like and effector Tph cells play distinct roles in RA pathogenesis.
🔗https://www.science.org/doi/10.1126/sciimmunol.adt3955
Exciting illustration by @chimomonga.bsky.social depicting cells as robots and dogs🤖🐶
#RA
#Tph
Reposted by Yuki Masuo M.D.
The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice!
wwwscience.org/toc/sciimmun...
wwwscience.org/toc/sciimmun...
August 1, 2025 at 8:21 PM
The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice!
wwwscience.org/toc/sciimmun...
wwwscience.org/toc/sciimmun...
Reposted by Yuki Masuo M.D.
Our study on immune responses in synovial tissue of patients with rheumatoid arthritis reveals the involvement of an evolutionary novel cytokine IGFL2 in the pathogenesis.
@sciimmunology.bsky.social
doi.org/10.1126/scii...
@sciimmunology.bsky.social
doi.org/10.1126/scii...
Human CD4+ T cells regulate peripheral immune responses in rheumatoid arthritis via insulin-like growth factor–like family member 2
IGFL2 is preferentially expressed by TPH cells and influences CD4+ T differentiation and macrophage activation in rheumatoid arthritis.
doi.org
August 2, 2025 at 12:31 AM
Our study on immune responses in synovial tissue of patients with rheumatoid arthritis reveals the involvement of an evolutionary novel cytokine IGFL2 in the pathogenesis.
@sciimmunology.bsky.social
doi.org/10.1126/scii...
@sciimmunology.bsky.social
doi.org/10.1126/scii...
New paper from our lab published in Science Immunology.
IGFL2, a previously uncharacterized cytokine, is produced by peripheral helper T cells (Tph cells) and regulates local immune response in rheumatoid arthritis.
www.science.org/doi/10.1126/...
IGFL2, a previously uncharacterized cytokine, is produced by peripheral helper T cells (Tph cells) and regulates local immune response in rheumatoid arthritis.
www.science.org/doi/10.1126/...
Human CD4+ T cells regulate peripheral immune responses in rheumatoid arthritis via insulin-like growth factor–like family member 2
IGFL2 is preferentially expressed by TPH cells and influences CD4+ T differentiation and macrophage activation in rheumatoid arthritis.
www.science.org
August 2, 2025 at 1:53 AM
New paper from our lab published in Science Immunology.
IGFL2, a previously uncharacterized cytokine, is produced by peripheral helper T cells (Tph cells) and regulates local immune response in rheumatoid arthritis.
www.science.org/doi/10.1126/...
IGFL2, a previously uncharacterized cytokine, is produced by peripheral helper T cells (Tph cells) and regulates local immune response in rheumatoid arthritis.
www.science.org/doi/10.1126/...
Honored to receive this award last week in Boston. Thank you @focisimmunology.bsky.social @britsocimm.bsky.social for the recognition.
#FOCIS2025
#FOCIS2025
FOCIS also wants to congratulate the 2025 recipient of the British Society for Immunology (BSI) Poster Prize Award - Yuki Masuo, MD 👏
#FOCIS2025
#FOCIS2025
July 1, 2025 at 11:13 PM
Honored to receive this award last week in Boston. Thank you @focisimmunology.bsky.social @britsocimm.bsky.social for the recognition.
#FOCIS2025
#FOCIS2025
Looking forward to this symposium!
Come join us next week to hear @kuchroolab.bsky.social talk about exciting new work @lji.org
May 29, 2025 at 4:00 AM
Looking forward to this symposium!
Recent paper from our lab published in @brain1878.bsky.social
Great example of an in-depth analysis using tissue-derived samples.
Great example of an in-depth analysis using tissue-derived samples.
By analysing CSF and blood samples from patients with acute neuromyelitis optica, Nishigori et al. identify dominant B cell subsets that differentiate into cells producing pathogenic antibodies within the CNS. buff.ly/JHLGO3g
May 3, 2025 at 1:56 PM
Recent paper from our lab published in @brain1878.bsky.social
Great example of an in-depth analysis using tissue-derived samples.
Great example of an in-depth analysis using tissue-derived samples.
Reposted by Yuki Masuo M.D.
Nature research paper: Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease
https://go.nature.com/4ikgYEu
https://go.nature.com/4ikgYEu
Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease - Nature
After transplantation into the brain of patients with Parkinson’s disease, allogeneic dopaminergic progenitors derived from induced pluripotent stem cells survived, produced dopamine and did not form tumours, therefore suggesting safety and potential clinical benefits for Parkinson’s disease.
go.nature.com
April 16, 2025 at 4:43 PM
Nature research paper: Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease
https://go.nature.com/4ikgYEu
https://go.nature.com/4ikgYEu
Our Meeting Report is out in Nature Immunology 📣
The 22nd Takeda Science Foundation Symposium on Bioscience and The 1st Kyoto Immunology Symposium featured human immunology researches (1/2)
www.nature.com/articles/s41...
The 22nd Takeda Science Foundation Symposium on Bioscience and The 1st Kyoto Immunology Symposium featured human immunology researches (1/2)
www.nature.com/articles/s41...
Human immunology soars in Japan - Nature Immunology
To address the increasing importance of studying immunology in humans, rather than a reliance on model systems, back-to-back symposia highlighting advances in human immunology were held in Osaka and K...
www.nature.com
April 4, 2025 at 11:46 AM
Our Meeting Report is out in Nature Immunology 📣
The 22nd Takeda Science Foundation Symposium on Bioscience and The 1st Kyoto Immunology Symposium featured human immunology researches (1/2)
www.nature.com/articles/s41...
The 22nd Takeda Science Foundation Symposium on Bioscience and The 1st Kyoto Immunology Symposium featured human immunology researches (1/2)
www.nature.com/articles/s41...
Reposted by Yuki Masuo M.D.
Masaki Kashiwara is the first Japanese person to be awarded the most prestigious prize in mathematics
https://go.nature.com/4l4cy7f
https://go.nature.com/4l4cy7f
Mathematician who reshaped theory of symmetry wins Abel Prize
Masaki Kashiwara is the first Japanese person to be awarded the most prestigious prize in mathematics.
go.nature.com
March 26, 2025 at 11:20 AM
Masaki Kashiwara is the first Japanese person to be awarded the most prestigious prize in mathematics
https://go.nature.com/4l4cy7f
https://go.nature.com/4l4cy7f