Yttri Lab
@yttrilab.bsky.social
Interrogating the functional interactions of motor and decision circuits that lead to behavior
https://labs.bio.cmu.edu/yttri/
https://labs.bio.cmu.edu/yttri/
SPNs are briefly active + only for specific events. When driven randomly or for long dur, interpretation is hard. SPN attenuate response to light after a few secs (and Bstem response?)
These results indicate STR's role in policy-based RL + are at odds with basic action selection
These results indicate STR's role in policy-based RL + are at odds with basic action selection
November 14, 2025 at 3:10 PM
SPNs are briefly active + only for specific events. When driven randomly or for long dur, interpretation is hard. SPN attenuate response to light after a few secs (and Bstem response?)
These results indicate STR's role in policy-based RL + are at odds with basic action selection
These results indicate STR's role in policy-based RL + are at odds with basic action selection
When applied contra, ipsi, or bilaterally to left turns, the effect was the same: D1/D2 stim biased mice to turn left more often, regardless of the side of stim. Note, bias is incomplete and did not induce an action, consistent with learning but not action selection
November 14, 2025 at 3:10 PM
When applied contra, ipsi, or bilaterally to left turns, the effect was the same: D1/D2 stim biased mice to turn left more often, regardless of the side of stim. Note, bias is incomplete and did not induce an action, consistent with learning but not action selection
Stim had a minimum duration of 450ms to better align to the ongoing behavior, but persisted as long as the locomotor arrest
*D1 stim biased mice to STOP MORE and remain stopped*
*D2 stim biased mice to STOP LESS and abort stops*
Peak speed was unaffected
*D1 stim biased mice to STOP MORE and remain stopped*
*D2 stim biased mice to STOP LESS and abort stops*
Peak speed was unaffected
November 14, 2025 at 3:10 PM
Stim had a minimum duration of 450ms to better align to the ongoing behavior, but persisted as long as the locomotor arrest
*D1 stim biased mice to STOP MORE and remain stopped*
*D2 stim biased mice to STOP LESS and abort stops*
Peak speed was unaffected
*D1 stim biased mice to STOP MORE and remain stopped*
*D2 stim biased mice to STOP LESS and abort stops*
Peak speed was unaffected
SPNs are briefly active + only for specific events. When driven randomly or for long dur, interpretation is hard. SPN attenuate response to light after a few secs (and Bstem response?)
These results indicate STR's role in policy-based RL + are at odds with basic action selection
These results indicate STR's role in policy-based RL + are at odds with basic action selection
November 12, 2025 at 9:33 PM
SPNs are briefly active + only for specific events. When driven randomly or for long dur, interpretation is hard. SPN attenuate response to light after a few secs (and Bstem response?)
These results indicate STR's role in policy-based RL + are at odds with basic action selection
These results indicate STR's role in policy-based RL + are at odds with basic action selection
When applied contra, ipsi, or bilaterally to left turns, the effect was the same: D1/D2 stim biased mice to turn left more often, regardless of the side of stim. Note, bias is incomplete and did not induce an action, consistent with learning but not action selection
November 12, 2025 at 9:33 PM
When applied contra, ipsi, or bilaterally to left turns, the effect was the same: D1/D2 stim biased mice to turn left more often, regardless of the side of stim. Note, bias is incomplete and did not induce an action, consistent with learning but not action selection
Even when behavior partially recovered after 10+ days, kinematic tuning in striatum did not. Several lines of evidence point to this being delayed due to remapping in cortex. Reaches were performed but were varied, in line with aberrant striatal activity
February 12, 2025 at 10:06 PM
Even when behavior partially recovered after 10+ days, kinematic tuning in striatum did not. Several lines of evidence point to this being delayed due to remapping in cortex. Reaches were performed but were varied, in line with aberrant striatal activity
What about striatum? @markolas.bsky.social recorded daily for 20 days post lesion and found that although baseline activity was unchanged, no motor-related signals were present for those movements that did occur, either in SPNs nor FSIs.
February 12, 2025 at 10:06 PM
What about striatum? @markolas.bsky.social recorded daily for 20 days post lesion and found that although baseline activity was unchanged, no motor-related signals were present for those movements that did occur, either in SPNs nor FSIs.
Following lesions, for the first 8-9 days, mice could not do the task. Also, while they could walk fine-they froze in place for MINUTES when deciding to go left or right or switch their motor pattern to navigate around an easy obstacle (unrewarded).
This also went away over several days.
This also went away over several days.
February 12, 2025 at 10:06 PM
Following lesions, for the first 8-9 days, mice could not do the task. Also, while they could walk fine-they froze in place for MINUTES when deciding to go left or right or switch their motor pattern to navigate around an easy obstacle (unrewarded).
This also went away over several days.
This also went away over several days.