Yttri Lab
@yttrilab.bsky.social
Interrogating the functional interactions of motor and decision circuits that lead to behavior
https://labs.bio.cmu.edu/yttri/
https://labs.bio.cmu.edu/yttri/
Hot off the @nature.com press!!
Our A-SOiD behavior library developed specifically for pain to quantify a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties
@flybottleescape.bsky.social @cmu-neuroscience.bsky.social @cmu.edu
www.nature.com/articles/s41...
Our A-SOiD behavior library developed specifically for pain to quantify a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties
@flybottleescape.bsky.social @cmu-neuroscience.bsky.social @cmu.edu
www.nature.com/articles/s41...
Mimicking opioid analgesia in cortical pain circuits - Nature
The anterior cingulate cortex encodes affective pain behaviours modulated by opioids; targeting opioid-sensitive neurons through a new chemogenetic gene therapy replicates the analgesic effects of mor...
www.nature.com
January 7, 2026 at 5:05 PM
Hot off the @nature.com press!!
Our A-SOiD behavior library developed specifically for pain to quantify a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties
@flybottleescape.bsky.social @cmu-neuroscience.bsky.social @cmu.edu
www.nature.com/articles/s41...
Our A-SOiD behavior library developed specifically for pain to quantify a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties
@flybottleescape.bsky.social @cmu-neuroscience.bsky.social @cmu.edu
www.nature.com/articles/s41...
So proud of @mattgeramita.bsky.social and this stellar work on striatal dynamics, decisions, and impulsivity. Really pertinent for thinking about probabilistic vs deterministic frameworks too
And yes the song by @ahmarilab.bsky.social is absolutely worth listening to!
And yes the song by @ahmarilab.bsky.social is absolutely worth listening to!
Excited to share my postdoc work with @yttrilab.bsky.social and @ahmarilab.bsky.social where we show that the striatal indirect pathway mediates hesitation in mice (www.nature.com/articles/s41...).
And I'm honored to have @ahmarilab.bsky.social introduce the findings with a musical abstract!
And I'm honored to have @ahmarilab.bsky.social introduce the findings with a musical abstract!
December 17, 2025 at 9:34 PM
So proud of @mattgeramita.bsky.social and this stellar work on striatal dynamics, decisions, and impulsivity. Really pertinent for thinking about probabilistic vs deterministic frameworks too
And yes the song by @ahmarilab.bsky.social is absolutely worth listening to!
And yes the song by @ahmarilab.bsky.social is absolutely worth listening to!
I hope this new-ish paper will challenge people to think about the interpretations of our models
STRIATUM SUPPORTS REINFORCEMENT AND NOT ACTION SELECTION (!!!)
tinyurl.com/HodgeAndYttri
@cmuscience.bsky.social
@cmu-neuroscience.bsky.social
#neuroskyence
STRIATUM SUPPORTS REINFORCEMENT AND NOT ACTION SELECTION (!!!)
tinyurl.com/HodgeAndYttri
@cmuscience.bsky.social
@cmu-neuroscience.bsky.social
#neuroskyence
Striatal modulation supports context-specific reinforcement and not action selection
Hodge et al. used closed-loop optogenetic stimulation and naturalistic behaviors to
determine that striatal activity does not select the action to perform but rather
biases performance through reinfor...
tinyurl.com
November 14, 2025 at 3:10 PM
I hope this new-ish paper will challenge people to think about the interpretations of our models
STRIATUM SUPPORTS REINFORCEMENT AND NOT ACTION SELECTION (!!!)
tinyurl.com/HodgeAndYttri
@cmuscience.bsky.social
@cmu-neuroscience.bsky.social
#neuroskyence
STRIATUM SUPPORTS REINFORCEMENT AND NOT ACTION SELECTION (!!!)
tinyurl.com/HodgeAndYttri
@cmuscience.bsky.social
@cmu-neuroscience.bsky.social
#neuroskyence
In an effort to bring #neuroskyence to @bsky.app I wanted to share our recent paper in Neuron
tinyurl.com/LesionsOfM1
@markolas.bsky.social and I asked what forelimb M1 contributes to striatal and behavioral dynamics using joystick tasks and CFA lesions
@cmuscience.bsky.social @the-cnbc.bsky.social
tinyurl.com/LesionsOfM1
@markolas.bsky.social and I asked what forelimb M1 contributes to striatal and behavioral dynamics using joystick tasks and CFA lesions
@cmuscience.bsky.social @the-cnbc.bsky.social
Motor cortex is responsible for motoric dynamics in striatum and the execution of both skilled and unskilled actions
Nicholas and Yttri find that in the absence of motor cortex, the stratum alone is
not capable of producing goal-directed behavior. Lesions of motor cortex also produce
a freezing of gait-like behavior...
tinyurl.com
February 12, 2025 at 10:06 PM
In an effort to bring #neuroskyence to @bsky.app I wanted to share our recent paper in Neuron
tinyurl.com/LesionsOfM1
@markolas.bsky.social and I asked what forelimb M1 contributes to striatal and behavioral dynamics using joystick tasks and CFA lesions
@cmuscience.bsky.social @the-cnbc.bsky.social
tinyurl.com/LesionsOfM1
@markolas.bsky.social and I asked what forelimb M1 contributes to striatal and behavioral dynamics using joystick tasks and CFA lesions
@cmuscience.bsky.social @the-cnbc.bsky.social