Oncogene - Bioinformatics advances in eccDNA identification and analysis

Executive order on gain-of-function experiments could chill research on infectious diseases, scientists say

In our recent study, we uncovered astrocyte-secreted factors, nature’s developmental "food sources", can enhance organoid maturation. This discovery advances organoid technology and underscores the nutrients essential for human brain health and development.

Realistic-lithosphere numerical models suggest glacial forcing in the last glacial cycle notably affected plate motions and mid-ocean-ridge spreading rates near major ice sheets, with implications for...

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The cucumber is among the top five vegetable crops grown in the world. Cucumbers are most commonly eaten fresh or preserved as pickles. An important attribute of the cucumber is fruit length. Cucumber...

Rice feeds billions daily, but it also fuels climate change. Scientists are pioneering new techniques to cut emissions and make rice farming more sustainable.

This Review explores how experimental models of metastasis, such as mouse models and cell cultures, can complement the (multi)omics analysis of human metastasis samples, thereby filling knowledge gaps...

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Superoxide anion is thought to be a natural by-product with strong oxidizing ability in all living organisms and was recently found to accumulate in plant meristems to maintain stem cells in the shoot and undifferentiated meristematic cells in the root. Here we show that the DNA demethylase repressor of silencing 1 (ROS1) is one of the direct targets of superoxide in stem cells. The Fe–S clusters in ROS1 are oxidized by superoxide to activate its DNA glycosylase/lyase activity. We demonstrate that superoxide extensively participates in the establishment of active DNA demethylation in the Arabidopsis genome and that ARABIDOPSIS RESPONSE REGULATOR 12 acts downstream of ROS1-mediated superoxide signaling to maintain stem cell fate. Our results provide a mechanistic framework for superoxide control of the stem cell niche and demonstrate how redox and DNA demethylation interact to define stem cell fate in plants. Superoxide oxidizes the iron–sulfur cluster in the DNA demethylase ROS1 and ex

A complex regulatory network controls the removal of toxic steroidal glycoalkaloids during tomato ripening.

Plant biology is undergoing a spatial omics revolution, but these approaches are limited to snapshots of a plant's state. Direct, genetically encoded fluorescent biosensors complement the omics a...

A new computational approach eliminates time-intensive imaging, enabling high-resolution spatial mapping of gene expression in tissue.

An imaging-free spatial transcriptomics method facilitates high-throughput barcode array generation up to centimeter scale.

Plants grow complex root systems to extract unevenly distributed resources from soils. Spatial differences in soil moisture are perceived by root tips, leading to the patterning of new root branches t...

Neuroscience institutes tells 10 scientists placed on leave it’s working on a “long-term” solution to officially reinstating them

Peter Marks, the FDA's top vaccine official ousted by Robert F. Kennedy Jr. said the U.S. health secretary's team sought nonexistent data to justify antivaccine narratives, the Wall Street Journal reported on Friday.

Forest soils provide important ecosystem services, such as biodiversity support, nutrient cycling, carbon sequestration, water regulation and erosion control.