Yacoub Innabi
@yacoubinnabi.bsky.social
I am a PhD Candidate in the Hernday Lab at UC Merced. I currently study the epigenetics of the white-opaque switch in C. albicans.
I get butterflies when omics technologies get married.
A little late to this, but very happy to see this nice paper from @nilskrietenstein.bsky.social and co out now at @natcomms.nature.com 🍻 www.nature.com/articles/s41...
Deciphering histone mark-specific fine-scale chromatin organization at high resolution with Micro-C-ChIP - Nature Communications
Here, the authors introduce Micro-C-ChIP, a strategy combining Micro-C with chromatin immunoprecipitation to map 3D genome organization at nucleosome resolution for defined histone modifications.
www.nature.com
December 2, 2025 at 5:05 PM
I get butterflies when omics technologies get married.
Have you ever wondered how enhancers and gene promoters find each other? One possible explanation is the binding of enhancer RNA to target antisense promoter RNA. You can detect these non-coding RNA interactions using a relatively new biotechnology called in situ conformation sequencing (RIC-seq).
RIC-seq for global in situ profiling of RNA–RNA spatial interactions - Nature
RNA in situ conformation sequencing (RIC-seq) enables the generation of three-dimensional interaction maps of RNA in cells, which sheds light on the interactions and regulatory functions of RNA.
www.nature.com
December 2, 2025 at 6:49 AM
Have you ever wondered how enhancers and gene promoters find each other? One possible explanation is the binding of enhancer RNA to target antisense promoter RNA. You can detect these non-coding RNA interactions using a relatively new biotechnology called in situ conformation sequencing (RIC-seq).
Have you performed CUT&RUN and forgot to add spike-in normalization? No worries! The CUT&RUN greenlist (pubmed.ncbi.nlm.nih.gov/38279652/) can accurately normalize your samples computationally by selecting low-entropy regions. The method looks accurate but I still have questions...
The CUT&RUN greenlist: genomic regions of consistent noise are effective normalizing factors for quantitative epigenome mapping - PubMed
Cleavage Under Targets and Release Using Nuclease (CUT&RUN) is a recent development for epigenome mapping, but its unique methodology can hamper proper quantitative analyses. As traditional normalization approaches have been shown to be inaccurate, we sought to determine endogenous normalization …
pubmed.ncbi.nlm.nih.gov
December 1, 2025 at 1:04 AM
Have you performed CUT&RUN and forgot to add spike-in normalization? No worries! The CUT&RUN greenlist (pubmed.ncbi.nlm.nih.gov/38279652/) can accurately normalize your samples computationally by selecting low-entropy regions. The method looks accurate but I still have questions...