Great thread! I’d like to add that TFs can genuinely be located at nucleosomal DNA. If that is the case, you might be looking at a pioneering factor.

Great paper! The section on variable number tandem repeats within genes blew my mind. I have never heard of them before.

What brand of LLPS do you support? My circle is starting to explore transcriptional condensates so this got my attention.

#bioinformatics #biology #epigenetics

Did the method not work for ChIP-seq or MNase-seq? Surely there are low-entropy regions in MNase-seq because there should be equal nucleosome peaks throughout the genome. Seems like applying this method to other omics data could be low-hanging fruit for publication.