With the first blood test for AD approved for clinical use, there may be great use of it to infer regional pathology when PET is not an option. Hasom Moon (the first author of the paper) is now studying the discordant cases to better understand and maximize the use of blood-based biomarkers!

With these relationships, we can use p-tau217 to estimate the staging/severity of tau in the brain🧠. The comparison between p-tau217-estimated tau map and actual tau PET shows high similarities(!) for both cross-sectional estimation (top) and longitudinal prediction (bottom)!

I’d love to be added if possible! Thank you!

I’d love to be added if possible. Thank you!

I’d love to be added if possible! Thank you!

I’d love to be added if possible! Thank you!

I’d love to be added if possible! Thanks!

I’d love to be added! Thank you for creating it!

🤩 would love to be added!

Many thanks to my coauthors who are not on Bluesky!🙏 We are excited about these interesting results! It gives us more hope🤩 in localizing early pathology and neural deficits driving differential cog declines, which is part of my current research! (I'm recruiting PhD students🧑‍🎓 if you are interested!)

We think these specific pathology-cog relationships may be due to the regions' functional roles and the particular vulnerabilities of the frontal-parietal (executive) network to Aβ and temporal (memory) network to tau in the very early stage of AD development!

Then relating the domain-specific residuals to PET change, we found Aβ increases in right frontoparietal tracked EF decline, but not memory, even after controlling for tau change; tau increases in left MTL tracked memory decline, but not EF, after controlling for Aβ change -- a double dissociation?!

Using longitudinal data in 76 older adults from the Berkeley Aging Cohort Study (~3 yrs PET, ~5 yrs cog), we first calculated domain-specific cog change residuals that represent how much faster their EF declined than expected based on their rate of memory decline (and vice versa)

The application deadline is Jan 15! Our PhD students are fully funded; if you are a US domestic student, we encourage you to apply before Dec 15 for consideration for additional fellowship!
#neuroskyence #psychscisky #psychjobs #academicsky #BlackInNeuro #Neuroimaging #cogpsyc #Psychology #PhDSky