🚨Please join us today (Monday 11/17) at 4pm in Room 4 to #AskAnything to Editor-in-Chief of Journal of Neuroscience @sfnjournals.bsky.social Dr. Sabine Kastner about scientific publishing and our board! Early career researchers are especially welcome! @sfn.org
#Sfn2025 #SfN25

🚨Please apply/RT! The Department of Psychology at Stony Brook University (SUNY- Stony Brook) is hiring a tenure track Assistant Professor in integrative neuroscience. We are in beautiful Long Island. Come work with us! apply.interfolio.com/171691 #neuroskyence #PsychSciSky @futurepislack.bsky.social

🚨If you are in Toronto for #AAIC25, come to room701 at 2pm today (Tuesday)! I’ll present in the developing topic session on tau biomarkers!🩸->🧠

Hi Early Career Researchers (ECR) in neuroscience!🧠 I've had a great time working as an ECR advisory board member in the Journal of Neuroscience @sfnjournals.bsky.social and learned so much from my peers and journal editors! We now invite you to join us! @sfn.org www.jneurosci.org/content/ecr-...

With these relationships, we can use p-tau217 to estimate the staging/severity of tau in the brain🧠. The comparison between p-tau217-estimated tau map and actual tau PET shows high similarities(!) for both cross-sectional estimation (top) and longitudinal prediction (bottom)!

First paper from CHEN lab!🩸->🧠Can we use p-tau217 value to estimate PET-like map of AD pathology?🤔 We say YES!💡In two datasets (A4, ADNI), p-tau217 level can predict concurrent Ab (but NOT Ab change) and future tau accumulation almost everywhere!
www.sciencedirect.com/science/arti...

We think these specific pathology-cog relationships may be due to the regions' functional roles and the particular vulnerabilities of the frontal-parietal (executive) network to Aβ and temporal (memory) network to tau in the very early stage of AD development!

Then relating the domain-specific residuals to PET change, we found Aβ increases in right frontoparietal tracked EF decline, but not memory, even after controlling for tau change; tau increases in left MTL tracked memory decline, but not EF, after controlling for Aβ change -- a double dissociation?!

Using longitudinal data in 76 older adults from the Berkeley Aging Cohort Study (~3 yrs PET, ~5 yrs cog), we first calculated domain-specific cog change residuals that represent how much faster their EF declined than expected based on their rate of memory decline (and vice versa)

The application deadline is Jan 15! Our PhD students are fully funded; if you are a US domestic student, we encourage you to apply before Dec 15 for consideration for additional fellowship!
#neuroskyence #psychscisky #psychjobs #academicsky #BlackInNeuro #Neuroimaging #cogpsyc #Psychology #PhDSky

🚨I’m recruiting PhD students interested in neuroimaging of aging and Alzheimer’s disease to join my new lab at Stony Brook University. Deadline Dec 15. For anyone interested and going to #SfN2023, feel free to contact me! I’d love to chat in DC and answer any questions you may have! 🧠#neuroskyence

More importantly, tau-related memory decline was mediated by hippocampal atrophy in Aβ- individuals and by cortical thinning in Aβ + individuals. This suggests that tau may affect memory through different mechanisms in normal older people (PART?) and early AD.

Using voxel-wise analysis of tau, we found Aβ-dependent tau associations with memory decline in MTL and temporoparietal regions, Aβ-independent MTL tau associations with hippocampal atrophy, and widespread cortical tau associations with cortical thinning in AD signature regions.