Xiaoxuan Lin
@xiaoxuan-lin.bsky.social
Ion channels, membrane proteins, HDX-MS & cryo-EM. Postdoc UCSF. Ph.D. UChicago.
🚨New preprint! ❄️🧊
How does TRPM8 sense cold/menthol?
We combine cryoEM and HDX-MS to uncover the hidden dynamics that drive cold activation. A great case where thermodynamics + structures together uncover conformational landscape & function.
www.biorxiv.org/content/10.1...
How does TRPM8 sense cold/menthol?
We combine cryoEM and HDX-MS to uncover the hidden dynamics that drive cold activation. A great case where thermodynamics + structures together uncover conformational landscape & function.
www.biorxiv.org/content/10.1...
The structural basis of cold sensitivity
Thermosensitive TRP ion channels enable somatosensory nerve fibers to detect changes in our thermal environment over a wide physiologic range. In mammals, the menthol receptor, TRPM8, is activated by ...
www.biorxiv.org
June 10, 2025 at 4:50 AM
🚨New preprint! ❄️🧊
How does TRPM8 sense cold/menthol?
We combine cryoEM and HDX-MS to uncover the hidden dynamics that drive cold activation. A great case where thermodynamics + structures together uncover conformational landscape & function.
www.biorxiv.org/content/10.1...
How does TRPM8 sense cold/menthol?
We combine cryoEM and HDX-MS to uncover the hidden dynamics that drive cold activation. A great case where thermodynamics + structures together uncover conformational landscape & function.
www.biorxiv.org/content/10.1...
Reposted by Xiaoxuan Lin
Ever wonder how many lives have been saved by NIH-funded research - including your own? Enter any medical condition and instantly see how your tax dollars transformed science into survival.
www.ourhealthroi.com
www.ourhealthroi.com
Our Health ROI
Explore how your tax dollars fund life‑saving medical research.
www.ourhealthroi.com
April 21, 2025 at 3:51 AM
Ever wonder how many lives have been saved by NIH-funded research - including your own? Enter any medical condition and instantly see how your tax dollars transformed science into survival.
www.ourhealthroi.com
www.ourhealthroi.com
Reposted by Xiaoxuan Lin
Now published in JCIM! Thanks to reviewers and our editor for pushing us to (hopefully) clarify a few things and ensure it's clear what PENGUIN is trying to do (and what it's NOT trying to do).
Also, in case you were unsure, graphic design is our passion.
pubs.acs.org/doi/full/10....
Also, in case you were unsure, graphic design is our passion.
pubs.acs.org/doi/full/10....
March 5, 2025 at 2:50 PM
Now published in JCIM! Thanks to reviewers and our editor for pushing us to (hopefully) clarify a few things and ensure it's clear what PENGUIN is trying to do (and what it's NOT trying to do).
Also, in case you were unsure, graphic design is our passion.
pubs.acs.org/doi/full/10....
Also, in case you were unsure, graphic design is our passion.
pubs.acs.org/doi/full/10....
New toy is unboxed
March 6, 2025 at 11:39 PM
New toy is unboxed
Reposted by Xiaoxuan Lin
In lab’s #FIRSTPREPRINT, we present methods to measure nanometer-scale organization around & between specific proteins in condensates in live cells. We uncover unexpected heterogeneity for a liquid-like phase with local meshwork spanning 10-50nm, stemming from ribosome biogenesis in the nucleolus.
February 28, 2025 at 12:52 PM
In lab’s #FIRSTPREPRINT, we present methods to measure nanometer-scale organization around & between specific proteins in condensates in live cells. We uncover unexpected heterogeneity for a liquid-like phase with local meshwork spanning 10-50nm, stemming from ribosome biogenesis in the nucleolus.
Reposted by Xiaoxuan Lin
Let’s stop treating "leaving academia" as negative. Scientists train for academia, industry, or what suits them. Industry isn’t an alternative; it’s a choice. In fields like engineering, most PhDs go to industry, and no one calls it "leaving academia." We should train scientists for diverse paths.
More than 40% of postdoctoral researchers leave academia, according to a study of some 45,500 researchers’ careers
https://go.nature.com/3Ej9RxA
https://go.nature.com/3Ej9RxA
More than 40% of postdocs leave academia, study reveals
Nature - Publishing highly cited papers helps postdoctoral researchers to land a faculty job.
go.nature.com
January 26, 2025 at 11:03 AM
Let’s stop treating "leaving academia" as negative. Scientists train for academia, industry, or what suits them. Industry isn’t an alternative; it’s a choice. In fields like engineering, most PhDs go to industry, and no one calls it "leaving academia." We should train scientists for diverse paths.