@wellerchen.bsky.social
Reposted
Thrilled to see our paper out today in @cp-cancercell.bsky.social — in collaboration with @yardenasamuels.bsky.social @wellerchen.bsky.social and many others, we show how perturbing translation fidelity causes aberrant peptide generation in tumors and anti-tumor immune responses in vivo — 🧵here
March 27, 2025 at 4:01 PM
Thrilled to see our paper out today in @cp-cancercell.bsky.social — in collaboration with @yardenasamuels.bsky.social @wellerchen.bsky.social and many others, we show how perturbing translation fidelity causes aberrant peptide generation in tumors and anti-tumor immune responses in vivo — 🧵here
Reposted
What if a “mistake” made tumors easier to find? New PICI-funded study from co-first author @cmcginnis92 at @stanfordmedicine shows that removing TYW2 scrambles protein translation—producing signals that help the immune system detect and attack cancer.
🔗 www.cell.com/cancer-cell/...
🔗 www.cell.com/cancer-cell/...
Translation dysregulation in cancer as a source for targetable antigens
Weller et al. substantiate the role of translation dysregulation in mediating anti-tumor
immunity by demonstrating that TYW2 loss in melanoma cells induces aberrant peptide
MHC presentation, increasin...
www.cell.com
March 27, 2025 at 11:45 PM
What if a “mistake” made tumors easier to find? New PICI-funded study from co-first author @cmcginnis92 at @stanfordmedicine shows that removing TYW2 scrambles protein translation—producing signals that help the immune system detect and attack cancer.
🔗 www.cell.com/cancer-cell/...
🔗 www.cell.com/cancer-cell/...
Thanks a lot @acir-org.bsky.social for highlighting our work and generating this great illustration!!
Translation dysregulation may serve as a new source for identifying cancer-associated antigens, and may also help to predict responses to checkpoint blockade bit.ly/3E4OMY8 #CheckpointBlockade #CancerImmunotherapy @wellerchen.bsky.social @Samuels-lab.bsky.social @yardenasamuels.bsky.social
April 2, 2025 at 4:11 PM
Thanks a lot @acir-org.bsky.social for highlighting our work and generating this great illustration!!
Brilliant meeting at the #MICC2025 in Athens! I was fortunate to get a picture with my mentor @yardenasamuels.bsky.social next to my poster.
March 12, 2025 at 6:43 PM
Brilliant meeting at the #MICC2025 in Athens! I was fortunate to get a picture with my mentor @yardenasamuels.bsky.social next to my poster.