@wanunupore.bsky.social
Reposted
Love worms, molecular genetics, and big questions? We’re hiring a postdoc to build a CRISPRa toolkit to identify new aging mechanisms in C. elegans.
Email or DM me to find out more. Please share & repost!
Email or DM me to find out more. Please share & repost!
Postdoctoral Research Associate, Biology
About the Opportunity Job Summary The Apfeld Lab at Northeastern University is seeking a postdoctoral researcher to investigate how genes work together to determine the maximum lifespan of the nematod...
northeastern.wd1.myworkdayjobs.com
April 29, 2025 at 8:54 PM
Love worms, molecular genetics, and big questions? We’re hiring a postdoc to build a CRISPRa toolkit to identify new aging mechanisms in C. elegans.
Email or DM me to find out more. Please share & repost!
Email or DM me to find out more. Please share & repost!
Reposted
1/6 🧬New paper at @cp-cellsystems.bsky.social led by @sashafanari.bsky.social! Does pseudouridine (Ψ) dynamically respond to cell state? We used nanopore DRS + Mod-p ID to map Ψ in neuron-like cells under “normal” and “perturbed” conditions (healthy differentiation and unhealthy Pb2+ poisoning).
March 21, 2025 at 3:42 PM
1/6 🧬New paper at @cp-cellsystems.bsky.social led by @sashafanari.bsky.social! Does pseudouridine (Ψ) dynamically respond to cell state? We used nanopore DRS + Mod-p ID to map Ψ in neuron-like cells under “normal” and “perturbed” conditions (healthy differentiation and unhealthy Pb2+ poisoning).
Reposted
6/6 🙌 Future work will determine whether static sites are critical for cellular function while plastic sites fine-tune gene expression in response to environmental stressors.
Huge thanks to the team for all their hard work! @wanunupore.bsky.social @genometdcc.bsky.social
Huge thanks to the team for all their hard work! @wanunupore.bsky.social @genometdcc.bsky.social
March 21, 2025 at 3:42 PM
6/6 🙌 Future work will determine whether static sites are critical for cellular function while plastic sites fine-tune gene expression in response to environmental stressors.
Huge thanks to the team for all their hard work! @wanunupore.bsky.social @genometdcc.bsky.social
Huge thanks to the team for all their hard work! @wanunupore.bsky.social @genometdcc.bsky.social
Reposted
🧪🧬👩🔬🖥️
Do immortalized cells have a different RNA modification profile compared to primary cells? 🤔
@sashafanari.bsky.social @wanunupore.bsky.social @srouhanifard.bsky.social assess the most abundant RNA modification, pseudouridine, in primary and immortalized human T cells
👇
doi.org/10.1101/2025...
Do immortalized cells have a different RNA modification profile compared to primary cells? 🤔
@sashafanari.bsky.social @wanunupore.bsky.social @srouhanifard.bsky.social assess the most abundant RNA modification, pseudouridine, in primary and immortalized human T cells
👇
doi.org/10.1101/2025...
Direct RNA sequencing of primary human T cells reveals the impact of immortalization on mRNA pseudouridine modifications.
Immortalized cell lines are commonly used as proxies for primary cells in human biology research. For example, Jurkat leukemic T cells fundamentally contributed to uncovering T cell signaling, activat...
doi.org
March 10, 2025 at 8:49 PM
🧪🧬👩🔬🖥️
Do immortalized cells have a different RNA modification profile compared to primary cells? 🤔
@sashafanari.bsky.social @wanunupore.bsky.social @srouhanifard.bsky.social assess the most abundant RNA modification, pseudouridine, in primary and immortalized human T cells
👇
doi.org/10.1101/2025...
Do immortalized cells have a different RNA modification profile compared to primary cells? 🤔
@sashafanari.bsky.social @wanunupore.bsky.social @srouhanifard.bsky.social assess the most abundant RNA modification, pseudouridine, in primary and immortalized human T cells
👇
doi.org/10.1101/2025...
Reposted
Unbelievable news.
Pancreatic is one of the deadliest cancers.
New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.
www.nature.com/articles/s41...
Pancreatic is one of the deadliest cancers.
New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.
www.nature.com/articles/s41...
February 27, 2025 at 5:03 PM
Unbelievable news.
Pancreatic is one of the deadliest cancers.
New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.
www.nature.com/articles/s41...
Pancreatic is one of the deadliest cancers.
New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care.
www.nature.com/articles/s41...
Reposted
IT'S HAPPENING! The Woodstock of Biology 2.0 meets Night Science @nightsciencepod.bsky.social
10-13 of June in Prague & the Woods of Bohemia...
Be there or be REJECTED. #theconferencetoendallconferences
10-13 of June in Prague & the Woods of Bohemia...
Be there or be REJECTED. #theconferencetoendallconferences
February 7, 2025 at 2:57 PM
IT'S HAPPENING! The Woodstock of Biology 2.0 meets Night Science @nightsciencepod.bsky.social
10-13 of June in Prague & the Woods of Bohemia...
Be there or be REJECTED. #theconferencetoendallconferences
10-13 of June in Prague & the Woods of Bohemia...
Be there or be REJECTED. #theconferencetoendallconferences
Reposted
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
February 9, 2025 at 9:58 PM
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Reposted
The illegal cut of NIH indirect costs will mean at least $115M cut to University of Pittsburgh @fetterman.senate.gov @davemccormick.bsky.social. This means huge loss of middle and working class jobs and research trials for breakthrough treatments for residents of Pennsylvania, Ohio, & West Virginia
Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/
Estimated Single Year Loss of NIH Funding if 15% Indirect Cost Rate is Imposed
Based on analysis of 2024 NIH funding data. Sums are totals of losses in funding to programs if indirect costs had been capped at 15%
datawrapper.dwcdn.net
February 9, 2025 at 7:56 PM
The illegal cut of NIH indirect costs will mean at least $115M cut to University of Pittsburgh @fetterman.senate.gov @davemccormick.bsky.social. This means huge loss of middle and working class jobs and research trials for breakthrough treatments for residents of Pennsylvania, Ohio, & West Virginia
Reposted
They tried this 💩 in the first admin, proposing cuts of indirects to 10%, and it was resisted by Congress
Call your congresspeople, and remind them they have defended health research before, and they can do so again
Call your congresspeople, and remind them they have defended health research before, and they can do so again
February 8, 2025 at 12:33 AM
They tried this 💩 in the first admin, proposing cuts of indirects to 10%, and it was resisted by Congress
Call your congresspeople, and remind them they have defended health research before, and they can do so again
Call your congresspeople, and remind them they have defended health research before, and they can do so again
Reposted
Since there has been a lot of misinformation circulating since last night, I find this AAMC infographic helpful in illustrating which types of expenses are and are not covered by NIH indirect cost reimbursements.
February 8, 2025 at 11:32 PM
Since there has been a lot of misinformation circulating since last night, I find this AAMC infographic helpful in illustrating which types of expenses are and are not covered by NIH indirect cost reimbursements.
How will indirect cuts affect our research remains to be seen. Scary times! @northeasternu.bsky.social
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 10:09 PM
How will indirect cuts affect our research remains to be seen. Scary times! @northeasternu.bsky.social
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
Happy lunar new year!
January 31, 2025 at 1:29 AM
Happy lunar new year!
