Valentin Zufferey
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vzufferey.bsky.social
Valentin Zufferey
@vzufferey.bsky.social
Insatiably curious Biologist, I use microscopy and imaging to improve diagnostics of neurological disorders.
PhD in the making in @richetinlab.bsky.social at @unil.bsky.social
📌 Lausanne 🇨🇭
📸 🔬🔭 #standwithscience
🇫🇷 🇬🇧
Pinned
3-day #timelapse of #microscopy #live #imaging of neuron-glia cultures. Watch #astrocytes (highly motile) actively clearing deposited #Tau protein aggregates (fuzzy clusters). 🔍🧬 #Neuroscience #Tauopathies #Alzheimer
Reposted by Valentin Zufferey
The tragic landslide in Blatten gives me the excuse to tell you the story of how we found out Ice Ages existed. It's a cool story and the most important bit is rather similar to what's happening now.
Aerial view westward over the Blatten deposit and the newly formed lake upstream! 🧊🌊

📷Via Christian Petit/Linkedin
May 29, 2025 at 7:49 PM
Reposted by Valentin Zufferey
Extracellular PHF-tau modulates astrocyte mitochondrial dynamics and mediates neuronal connectivity.

https://pubmed.ncbi.nlm.nih.gov/40122883/

#neurodegeneration #tau #astrocyte
March 24, 2025 at 5:21 PM
Excited to participate to AD/PD In Vienna from 1-5 of April. I'll present a poster on our latest published work on extracellular #tau aggregates effects on brain cells' #mitochondria and #connectivity
pubmed.ncbi.nlm.nih.gov/40122883

Also looking forward to travelling there with night train 😬🚅
Extracellular PHF-tau modulates astrocyte mitochondrial dynamics and mediates neuronal connectivity - PubMed
These findings suggest that the accumulation of PHF-tau within astrocytes drives changes in mitochondrial biogenesis, which may influence synaptic regulation. This astrocyte-mediated adaptation to tau...
pubmed.ncbi.nlm.nih.gov
March 28, 2025 at 10:48 AM
🎉 First paper as 1st author!
We studied #astrocyte and #neuron responses to extracellular tau aggregates in #live #imaging: astrocyte #mitochondria adapt and influence #synapses! #neuroscience #tauopathies 🔬🧠
🔗 pubmed.ncbi.nlm.nih.gov/40122883/
March 24, 2025 at 3:08 PM
🎉Premier article en 1er auteur!🥳
Nous avons étudié la réaction d' #astrocytes et de #neurones aux agrégats de tau extracellulaires en #live #imaging: les #mitochondries astrocytaires s'adaptent et influencent les #synapses !
#neuroscience #tauopathies 🔬🧠
🔗 pubmed.ncbi.nlm.nih.gov/40122883/
March 24, 2025 at 3:08 PM
Reposted by Valentin Zufferey
Tiens Altmetric qui fait savoir à quel point Wikipedia c'est bien.

Chouette thread à lire.
THREAD

The Wonderful World of Wikipedia (WWW)

If you are of a certain age, Wikipedia has been a constant in your life. It was not always so.

Here is a pre-history, a history and potential future of the world's great shared book that we all read and write. Also why is it called "Wikipedia"?
1/30
March 6, 2025 at 12:09 PM
Reposted by Valentin Zufferey
J'essaye en 2mn de vous expliquer pourquoi Trump agit contre la science et pourquoi ça ne se limite pas aux USA.

Le mouvement américain : standupforscience.org
et chez les français : standupforscience.fr

#standupforscience #standupforsciencefrance

youtube.com/shorts/HYEh8...
Trump contre la science (vidéo n°436)
YouTube video by Julien Bobroff
youtube.com
March 7, 2025 at 7:16 AM
Reposted by Valentin Zufferey
Je crois en la #science comme clé pour comprendre notre monde et notre humanité.

Je me lève avec #StandUpForScience pour défendre la liberté d'expression de la recherche et son indépendance vis-à-vis de toute idéologie.

Ensemble, pour une science impartiale et éclairée.
March 7, 2025 at 10:54 AM
Reposted by Valentin Zufferey
More Nikon NSPARC confocal testing at the @ncis-marseille.bsky.social: super-resolved live-cell imaging (1 frame every 10 seconds) of a COS-7 cell labeled for DNA (blue), endosomes (pink) and actin (gray) using probes from @spirochrome.com
March 5, 2025 at 3:35 PM
Update dans la story "ressuciter le mammouth", on en est au "Sourimouth".

Manque juste les défenses et on est bons 😂
March 5, 2025 at 10:34 AM
La réaction légère et complaisante de l'audience est infiniment plus insupportable et effrayante que la confusion entre transgénique et transgenre...

Ceux se moquant de cette absurdité se rajoutent en fait la masse moqueuse et l'amplifie.

La strat sprayage de merde à encore un long avenir.
"8 million dollars for making mice transgender" is the new "they're eating the dogs"
March 5, 2025 at 10:00 AM
Reposted by Valentin Zufferey
Quand tu arrives à confonde "transGENIC mice" et "transGENDER mice", c'est que tu es celui qui as le plus besoin de la science que tu essayes d'étouffer depuis 2 mois.
"8 million dollars for making mice transgender" is the new "they're eating the dogs"
March 5, 2025 at 8:59 AM
Quand l'idée que notre génération puisse ne jamais voir la couleur d'une retraite semble de moins en moins fantasmée...
March 4, 2025 at 4:15 PM
Reposted by Valentin Zufferey
"Près de 60% des médicaments exposés dans les vitrines des pharmacies en Suisse n’ont pas d'efficacité médicalement prouvée. C’est la conclusion d’une étude menée par une équipe de médecins du Centre hospitalier Bienne"

Et si on vérifiait en France ?
www.rts.ch/info/science...
October 3, 2023 at 11:28 AM
Reposted by Valentin Zufferey
Nouvelle attaque contre les libertés et contre les universités
Chaque jour ce pouvoir révèle un peu plus son visage effrayant
March 4, 2025 at 3:31 PM
Reposted by Valentin Zufferey
Chloé et Angelo, stagiaires de 4e et 3e se sont demandés si le blob pouvait "grimper" pour obtenir des flocons d'avoine collés au plafond.
Réponse : no problémo!
March 4, 2025 at 11:43 AM
Reposted by Valentin Zufferey
« Défendons les sciences face aux nouveaux obscurantismes »

En écho au mouvement américain « Stand up for Science » contre la politique de Trump, un collectif de personnalités françaises appelle citoyens et scientifiques à une journée de mobilisation le 7 mars.

👇
www.lemonde.fr/sciences/art...
« Défendons les sciences face aux nouveaux obscurantismes »
TRIBUNE. En écho au mouvement américain de protestation contre la politique de Donald Trump, un collectif de personnalités françaises appelle citoyens et scientifiques à rejoindre le mouvement « Stand...
www.lemonde.fr
March 4, 2025 at 12:13 PM
Reposted by Valentin Zufferey
Les ARN messagers (ou ARNm) sont des molécules copiant l'information codée dans notre génome et la transportant dans la cellule pour permettre la synthèse des protéines.

Une nouvelle méthode de microscopie permet de voir ces ARNm bouger en temps réel dans la cellule.

1/2
February 18, 2025 at 3:37 PM
Reposted by Valentin Zufferey
I was just told that I have to remove “climate” from the title of an ongoing grant if I want to keep it. And publications from that grant cannot include “climate” and other forbidden words. I can’t believe I’m writing this from the United States of America. #AcademicSky
Just received an email saying that it's not advisable to include the following words in future applications for research funding to the US DOT. Here we are.
February 10, 2025 at 9:00 PM
Reposted by Valentin Zufferey
Just received an email saying that it's not advisable to include the following words in future applications for research funding to the US DOT. Here we are.
February 6, 2025 at 5:37 PM
Reposted by Valentin Zufferey
Nos collègues américains ne peuvent plus écrire des grants pour avoir des fonds avec certains mots clés dedans. Même le mot "CLIMAT" est de trop. C'est n'importe quoi.
I was just told that I have to remove “climate” from the title of an ongoing grant if I want to keep it. And publications from that grant cannot include “climate” and other forbidden words. I can’t believe I’m writing this from the United States of America. #AcademicSky
Just received an email saying that it's not advisable to include the following words in future applications for research funding to the US DOT. Here we are.
February 11, 2025 at 7:37 AM
Reposted by Valentin Zufferey
Il y a eu l'annonce, c'est maintenant le tour des exemples d'application concrètes et ça ne perds pas de temps.

Certains chercheurs ne peuvent simplement pas faire leur travail de recherche quand un mot tel que "climat" est censuré.

C'est Glaçant.
I was just told that I have to remove “climate” from the title of an ongoing grant if I want to keep it. And publications from that grant cannot include “climate” and other forbidden words. I can’t believe I’m writing this from the United States of America. #AcademicSky
Just received an email saying that it's not advisable to include the following words in future applications for research funding to the US DOT. Here we are.
February 11, 2025 at 10:16 AM
Reposted by Valentin Zufferey
First, this is facism. It's not 'on the path' or 'a worrying precedent'. It's just facism.

Second, you cannot do any health or social science research if you ban 'bias', ethnicity', 'race', 'socioeconomic', 'female' etc.
That, of course, may be the plan. Fascist regimes don't like social science.
🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.
February 4, 2025 at 9:23 AM