The bacterial ubiquitin ligase NleL evades host defence mechanisms both by inhibiting pyroptosis and by preventing infected intestinal epithelial cells from being extruded into the lumen and expelled ...

It was previously demonstrated that intestinal pathogens have evolved different mechanisms to enhance their infection and colonization in the intestin…

This study aimed to utilize mRNA vaccine technology targeting conserved antigens (IpaB and IpaC) to overcome the limitations of previous Shigella vaccines. By demonstrating functional immune responses...

Eislmayr et al. reveal a previously unrecognized role of macrophages in controlling the intracellular pathogen Shigella. By sensing bacteria and triggering IFN-γ production, macrophages, not neutrophi...

Antibiotic-resistant infections, particularly those caused by intracellular pathogens, represent an urgent public health threat due to their ability to evade immune responses and resist conventional a...

Intracellular bacterial pathogens, including L. monocytogenes, spread from cell to cell to effectively disseminate within host tissues and cause systemic infections. We developed a fluorescence micros...

Rickettsia species are bacterial pathogens that obligately reside in the host cell cytosol. Here, Sun et al. report that Rickettsia use host glutathione as a nutrient source that enables bacterial cel...

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

Despite different infection strategies, enteric pathogens commonly employ a T3SS to colonize the human host and cause disease. Effector proteins are unique to each T3SS-encoding bacterial species and ...

Through metagenomics, Bray et al. identified Klebsiella pneumoniae interacting microbiota partners in the gut, and a transposon mutagenesis screen revealed a role for its T6SS in gut colonization, wit...

Epithelial cells respond to infection with the intracellular bacterial pathogen Listeria monocytogenes by altering their mechanics to promote collecti…

Peptidoglycan released by neighbouring kin or non-kin cell lysis induces physiological changes that protect from a range of stresses, including phage predation.

Shigellosis is an ongoing global public health crisis with >270 million annual episodes among all age groups; however, the greatest disease burden is among children in low- and middle-income countr...

Typhoid fever is a systemic infectious disease triggered by the gastrointestinal dissemination of Salmonella Typhi and Paratyphi in humans. Three to five percent of infected individuals become chronic...

Intracellular bacterial pathogens must adapt to a host cell environment to enable their growth, survival, and dissemination. Consequently, they have evolved various mechanisms to manipulate their host environments to create a more hospitable niche (1–5). One common way for pathogens to interact with host cells is through surface-associated and secreted effector proteins. Bacterial pathogen effectors are known to exert diverse functions, including inducing cellular invasion, establishing vacuolar compartments, remodeling host organelles, modifying the host immune response, and facilitating the spread of these pathogens between cells (6–11).

Inflammasomes are essential for host defense against intracellular bacterial pathogens like Legionella, as they activate caspases, which promote cytokine release and cell death to control infection. I...

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