Victor Montal
@vmontalb.bsky.social
Alzheimer research, compchem, bioinfo, neuroimaging, NBA
Reposted by Victor Montal
Network of somatosensory axons and immune cells in the adult zebrafish skin. Credit to @errricpeterman.bsky.social. #ZebrafishZunday 🧪
December 7, 2025 at 11:49 AM
Network of somatosensory axons and immune cells in the adult zebrafish skin. Credit to @errricpeterman.bsky.social. #ZebrafishZunday 🧪
Reposted by Victor Montal
Reposted by Victor Montal
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 12, 2025 at 9:26 PM
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Reposted by Victor Montal
Our new review is out today!
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks
Metabolic inflexibility in Alzheimer's disease. Schematic illustrating the biphasic trajectory of metabolic activity relative to canonical Alzheimer's disease (AD) biomarkers. In the presymptomatic p...
onlinelibrary.wiley.com
November 13, 2025 at 8:17 PM
Our new review is out today!
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Victor Montal
(1/n) Can diffusion models simulate molecular dynamics instead of just generating independent samples?
In our NeurIPS 2025 paper, we train energy-based diffusion models that can do both:
- Generate independent samples
- Learn the underlying potential 𝑼
🧵👇
Paper: arxiv.org/abs/2506.17139
In our NeurIPS 2025 paper, we train energy-based diffusion models that can do both:
- Generate independent samples
- Learn the underlying potential 𝑼
🧵👇
Paper: arxiv.org/abs/2506.17139
November 6, 2025 at 2:41 PM
(1/n) Can diffusion models simulate molecular dynamics instead of just generating independent samples?
In our NeurIPS 2025 paper, we train energy-based diffusion models that can do both:
- Generate independent samples
- Learn the underlying potential 𝑼
🧵👇
Paper: arxiv.org/abs/2506.17139
In our NeurIPS 2025 paper, we train energy-based diffusion models that can do both:
- Generate independent samples
- Learn the underlying potential 𝑼
🧵👇
Paper: arxiv.org/abs/2506.17139
Reposted by Victor Montal
La pareja de Ayuso termina su declaración en el Supremo: “O me voy de España o me suicido” www.eldiario.es/politica/ult...
November 4, 2025 at 6:33 PM
La pareja de Ayuso termina su declaración en el Supremo: “O me voy de España o me suicido” www.eldiario.es/politica/ult...
Reposted by Victor Montal
It's clear from the video footage that Billie Eilish felt slightly intimidated & apprehensive to call out billionaires in a room full of billionaires, but she did so anyway.
She did so anyway.
She did so anyway.
November 1, 2025 at 11:21 AM
It's clear from the video footage that Billie Eilish felt slightly intimidated & apprehensive to call out billionaires in a room full of billionaires, but she did so anyway.
She did so anyway.
She did so anyway.
Reposted by Victor Montal
OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇
October 28, 2025 at 6:30 PM
OpenFold3-preview (OF3p) is out: a sneak peek of our AF3-based structure prediction model. Our aim for OF3 is full AF3-parity for every modality. We now believe we have a clear path towards this goal and are releasing OF3p to enable building in the OF3 ecosystem. More👇
Reposted by Victor Montal
Accessible, uniform protein property prediction with a scikit-learn based toolset AIDE
Artificial Intelligence Driven protein Estimation (AIDE), enables instantiating, optimizing, and testing many zero-shot and supervised property prediction methods
doi.org/10.1093/bioi...
Artificial Intelligence Driven protein Estimation (AIDE), enables instantiating, optimizing, and testing many zero-shot and supervised property prediction methods
doi.org/10.1093/bioi...
October 29, 2025 at 7:45 AM
Accessible, uniform protein property prediction with a scikit-learn based toolset AIDE
Artificial Intelligence Driven protein Estimation (AIDE), enables instantiating, optimizing, and testing many zero-shot and supervised property prediction methods
doi.org/10.1093/bioi...
Artificial Intelligence Driven protein Estimation (AIDE), enables instantiating, optimizing, and testing many zero-shot and supervised property prediction methods
doi.org/10.1093/bioi...
Reposted by Victor Montal
Just because this came up a few times recently
If you need to compare two or more ensembles (like RMSD for structures) we developed algorithms and code (ENCORE) to do just that
Similarity Measures for Protein Ensembles
journals.plos.org/plosone/arti...
ENCORE
journals.plos.org/ploscompbiol...
If you need to compare two or more ensembles (like RMSD for structures) we developed algorithms and code (ENCORE) to do just that
Similarity Measures for Protein Ensembles
journals.plos.org/plosone/arti...
ENCORE
journals.plos.org/ploscompbiol...
October 27, 2025 at 8:00 AM
Just because this came up a few times recently
If you need to compare two or more ensembles (like RMSD for structures) we developed algorithms and code (ENCORE) to do just that
Similarity Measures for Protein Ensembles
journals.plos.org/plosone/arti...
ENCORE
journals.plos.org/ploscompbiol...
If you need to compare two or more ensembles (like RMSD for structures) we developed algorithms and code (ENCORE) to do just that
Similarity Measures for Protein Ensembles
journals.plos.org/plosone/arti...
ENCORE
journals.plos.org/ploscompbiol...
Reposted by Victor Montal
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
October 20, 2025 at 11:26 AM
We (@sobuelow.bsky.social) developed AF-CALVADOS to integrate AlphaFold and CALVADOS to simulate flexible multidomain proteins at scale
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
See preprint for:
— Ensembles of >12000 full-length human proteins
— Analysis of IDRs in >1500 TFs
📜 doi.org/10.1101/2025...
💾 github.com/KULL-Centre/...
Reposted by Victor Montal
Excited to share our new preprint “Unified Sampling and Ranking for Protein Docking with DFMDock” by PhD candidate Lee-Shin Chu and Post-Doc Sudeep Sarma! We designed a diffusion docking model that samples rigid-body conformations by predicting forces and ranks poses using predicted energies.
October 8, 2025 at 6:27 PM
Excited to share our new preprint “Unified Sampling and Ranking for Protein Docking with DFMDock” by PhD candidate Lee-Shin Chu and Post-Doc Sudeep Sarma! We designed a diffusion docking model that samples rigid-body conformations by predicting forces and ranks poses using predicted energies.
Reposted by Victor Montal
Reposted by Victor Montal
And the legacy continues! 😊
@amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social #EMBOIntegMod25 ! 🍀🧿
@amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social #EMBOIntegMod25 ! 🍀🧿
October 6, 2025 at 1:13 PM
And the legacy continues! 😊
@amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social #EMBOIntegMod25 ! 🍀🧿
@amjjbonvin.bsky.social @bioinfo.se @lindorfflarsen.bsky.social #EMBOIntegMod25 ! 🍀🧿
Reposted by Victor Montal
🙌 We have a new webinar next week on our series!
💻 These seminars online seminars are free of charge and you can register using the following link 👉 lnkd.in/dhXaHGYW
#WestNileVirus #Survelliance #Mosquito
💻 These seminars online seminars are free of charge and you can register using the following link 👉 lnkd.in/dhXaHGYW
#WestNileVirus #Survelliance #Mosquito
October 7, 2025 at 1:14 PM
🙌 We have a new webinar next week on our series!
💻 These seminars online seminars are free of charge and you can register using the following link 👉 lnkd.in/dhXaHGYW
#WestNileVirus #Survelliance #Mosquito
💻 These seminars online seminars are free of charge and you can register using the following link 👉 lnkd.in/dhXaHGYW
#WestNileVirus #Survelliance #Mosquito
Reposted by Victor Montal
It is often argued that the origin of life must be related to "phase transitions"
This concept is often misused, or even abused.
In a new paper with @ricardsole.bsky.social we discuss which types of transitions might be involved and some relevant models.
royalsocietypublishing.org/doi/full/10....
This concept is often misused, or even abused.
In a new paper with @ricardsole.bsky.social we discuss which types of transitions might be involved and some relevant models.
royalsocietypublishing.org/doi/full/10....
Bifurcations and phase transitions in the origins of life | Philosophical Transactions of the Royal Society B: Biological Sciences
The path towards the emergence of life in our biosphere involved several key events allowing for the persistence, reproduction and evolution of molecular systems. All these processes took place in a given environmental context and required both molecular ...
royalsocietypublishing.org
October 2, 2025 at 6:53 PM
It is often argued that the origin of life must be related to "phase transitions"
This concept is often misused, or even abused.
In a new paper with @ricardsole.bsky.social we discuss which types of transitions might be involved and some relevant models.
royalsocietypublishing.org/doi/full/10....
This concept is often misused, or even abused.
In a new paper with @ricardsole.bsky.social we discuss which types of transitions might be involved and some relevant models.
royalsocietypublishing.org/doi/full/10....
Reposted by Victor Montal
"AlphaFold-Multimer’s prediction accuracy is sensitive to the defined boundaries of the interacting partners" #alphafold
yep
www.pnas.org/doi/10.1073/...
yep
www.pnas.org/doi/10.1073/...
AlphaFold-Multimer accurately captures interactions and dynamics of intrinsically disordered protein regions | PNAS
Interactions mediated by intrinsically disordered protein regions (IDRs) pose formidable
challenges in structural characterization. IDRs are highly...
www.pnas.org
September 30, 2025 at 7:57 AM
"AlphaFold-Multimer’s prediction accuracy is sensitive to the defined boundaries of the interacting partners" #alphafold
yep
www.pnas.org/doi/10.1073/...
yep
www.pnas.org/doi/10.1073/...
Reposted by Victor Montal
Inflammatory reprogramming of human brain endothelial cells compromises blood-brain barrier integrity in Alzheimer's disease #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.09.26.678918v1
https://www.biorxiv.org/content/10.1101/2025.09.26.678918v1
September 28, 2025 at 4:02 PM
Inflammatory reprogramming of human brain endothelial cells compromises blood-brain barrier integrity in Alzheimer's disease #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.09.26.678918v1
https://www.biorxiv.org/content/10.1101/2025.09.26.678918v1
Reposted by Victor Montal
Traveling to beautiful Izmir tomorrow for the EMBO meeting on modeling biomolecules interactions, where I will present the CAPRI blind prediction experiment on Tuesday. Looking forward to it. Thanks to @ezgikaraca.bsky.social and other organizers for the invitation
meetings.embo.org/event/25-bio...
meetings.embo.org/event/25-bio...
Integrative modelling of biomolecular interactions
Experimental structural studies of interactions can be costly, low-throughput, and challenging. Therefore, computational methods aiming to model protein complexes are particularly valuable. The accur…
meetings.embo.org
September 27, 2025 at 6:25 PM
Traveling to beautiful Izmir tomorrow for the EMBO meeting on modeling biomolecules interactions, where I will present the CAPRI blind prediction experiment on Tuesday. Looking forward to it. Thanks to @ezgikaraca.bsky.social and other organizers for the invitation
meetings.embo.org/event/25-bio...
meetings.embo.org/event/25-bio...
Reposted by Victor Montal
The effect of spherical projections on spin tests for brain maps | doi.org/10.1162/IMAG...
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
September 10, 2025 at 1:07 PM
The effect of spherical projections on spin tests for brain maps | doi.org/10.1162/IMAG...
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️
Reposted by Victor Montal
Reposted by Victor Montal
🚨Fresh pre-print collab with @johnsonlab.bsky.social, Norton Healthcare, and our @uksbcoa.bsky.social collaborators. We report a coordinated CD8+ Tcell immunometabolic program associated with amyloid-related imaging abnormalities (ARIA) during lecanemab therapy👇
🔗 www.medrxiv.org/content/10.1...
🔗 www.medrxiv.org/content/10.1...
Clonal expansion of cytotoxic CD8⁺ T cells in lecanemab-associated ARIA
Amyloid related imaging abnormalities (ARIA) remain the principal safety concern limiting adoption of anti amyloid therapies such as lecanemab, yet their underlying biology is poorly defined. To addre...
www.medrxiv.org
September 22, 2025 at 12:20 PM
🚨Fresh pre-print collab with @johnsonlab.bsky.social, Norton Healthcare, and our @uksbcoa.bsky.social collaborators. We report a coordinated CD8+ Tcell immunometabolic program associated with amyloid-related imaging abnormalities (ARIA) during lecanemab therapy👇
🔗 www.medrxiv.org/content/10.1...
🔗 www.medrxiv.org/content/10.1...
Reposted by Victor Montal
Proud to present our new paper in @natmetabolism.nature.com
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
lnkd.in/eVzFrmUY
Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
lnkd.in/eVzFrmUY
Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
September 22, 2025 at 11:02 AM
Proud to present our new paper in @natmetabolism.nature.com
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
lnkd.in/eVzFrmUY
Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
lnkd.in/eVzFrmUY
Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).
Reposted by Victor Montal
Trump just designated “Antifa” as a terrorist organization, on par with ISIS and Al Qaeda. As a reminder, “antifa” is short for “antifascist”.
They will use this lie to surveil, imprison, and kill Americans on the left.
This may be our Reichstag Fire moment. Wake up.
www.cnn.com/2025/09/17/p...
They will use this lie to surveil, imprison, and kill Americans on the left.
This may be our Reichstag Fire moment. Wake up.
www.cnn.com/2025/09/17/p...
Trump says he’s designating Antifa as a terrorist organization | CNN Politics
President Donald Trump said he is designating the far-left anti-fascism movement Antifa as a terrorist organization, announcing the move on his Truth Social platform in the early hours of Thursday mor...
www.cnn.com
September 18, 2025 at 1:48 AM
Trump just designated “Antifa” as a terrorist organization, on par with ISIS and Al Qaeda. As a reminder, “antifa” is short for “antifascist”.
They will use this lie to surveil, imprison, and kill Americans on the left.
This may be our Reichstag Fire moment. Wake up.
www.cnn.com/2025/09/17/p...
They will use this lie to surveil, imprison, and kill Americans on the left.
This may be our Reichstag Fire moment. Wake up.
www.cnn.com/2025/09/17/p...
Reposted by Victor Montal
This World Alzheimer's Day, Dr Clíona Farrell reflects on progress and challenges in research, from blood biomarkers to new treatments. Read her blog now. #WorldAlzDay #WAD2025
www.dementiaresearcher.nihr.ac.uk/blog-world-a...
www.dementiaresearcher.nihr.ac.uk/blog-world-a...
Dr Clíona Farrell - Blog – World Alzheimer’s Day reflection
Dr Clíona Farrell reflects on progress, challenges, and hope in Alzheimer’s research this World Alzheimer’s Day, sharing why she's inspired to study the disease
www.dementiaresearcher.nihr.ac.uk
September 21, 2025 at 9:37 AM
This World Alzheimer's Day, Dr Clíona Farrell reflects on progress and challenges in research, from blood biomarkers to new treatments. Read her blog now. #WorldAlzDay #WAD2025
www.dementiaresearcher.nihr.ac.uk/blog-world-a...
www.dementiaresearcher.nihr.ac.uk/blog-world-a...