Loss of lean mass is a potential concern for semaglutide-induced weight loss. This study indicates that semaglutide has unexpected effects on skeletal muscle mass and strength in mice, demonstrating a...

Identifying the set of genes that regulate baseline healthy aging – aging that is not confounded by illness – is critical to understating aging biology. Machine learning-based age-estimators (such as ...

Long-term resistance training promotes skeletal muscle hypertrophy and boosts energy metabolism. The stress-inducible protein, SESN2 is a mediator of …

The pursuit for the elixir of eternal youth has fascinated scientists for centuries. Yet, natural ageing—marked by the gradual decline of biological, physiological, psychological, and behavioural proc...

Since the early 2000s, omics approaches to study skeletal muscle hypertrophy consequent to loading (e.g. resistance exercise) have expanded dramatically. Beginning with genomics and transcriptomics, t...

On 1–2 November 2024, the annual Biomarkers of Aging conference welcomed academic and industry scientists, and partners from governmental and nongovernmental organizations, to Harvard Medical School i...

Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately...

Nature Metabolism, Published online: 14 March 2025; doi:10.1038/s42255-025-01235-8SIRT5 protects against primate skeletal muscle ageing through TBK1 desuccinylation, which inhibits the downstream inflammatory and senescent phenotypes.

Nature Metabolism, Published online: 14 March 2025; doi:10.1038/s42255-025-01228-7Sarcopenia is one of the main contributors to the loss of independence in older adults. A study in primates demonstrates that SIRT5-mediated desuccinylation of TBK1 at Lys137 inhibits the activation of TBK1 and its downstream pro-inflammatory responses, thereby protecting skeletal muscle from ageing.

Nature Metabolism, Published online: 17 March 2025; doi:10.1038/s42255-025-01237-6This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological,…

Nature Metabolism, Published online: 14 March 2025; doi:10.1038/s42255-025-01254-5The cyclic metabolic switching theory of intermittent fasting

Nature Metabolism, Published online: 14 March 2025; doi:10.1038/s42255-025-01228-7Sarcopenia is one of the main contributors to the loss of independence in older adults. A study in primates demonstrates that SIRT5-mediated desuccinylation of TBK1 at…

In absence of oxidative stress (i.e., Control, left panel) Keap1 binds and ubiquitinates the antioxidant response element (ARE) transcription factor NRF2. Ubiquitinated NRF2 is degraded and unable to....

npj Metabolic Health and Disease - AMPK phosphosite profiling by label-free mass spectrometry reveals a multitude of mTORC1-regulated substrates

Insulin regulates glucose uptake and metabolism in muscle via the insulin receptor. Here we show that Lrtm1 (Leucine Rich Repeats and Transmembrane Domains