Congratulations! * Rapid epigenomic classification of acute leukemia* — the most innovative and impactful application of long-read sequencing and machine learning I know. Happy to be included!! #hemesky 🩸🧬💻🔬

Congratulations! * Rapid epigenomic classification of acute leukemia* — the most innovative and impactful application of long-read sequencing and machine learning I know. Happy to be included!! #hemesky 🩸🧬💻🔬

These findings provide new insight into blood aging at the source, and raise the possibility of targeting inflammatory HSCs to "rejuvenate" blood production in aging 🧪
Thanks Ksenia Safina and collaborators @trowbridgelab.bsky.social @bloodgenes.bsky.social Read more at doi.org/10.1101/2025... 5/5🏁

We discovered a type of stem cells that expand with age and is dominated by a program of inflammation and quiescence (GEP:1 below), which could leave the blood system less able to renew itself 📊 4/5

There is no clear agreement on the effects of aging on HSCs, and how different types of HSCs play into this. So we pulled seven datasets together and re-analyzed them using new bioinformatic methods, revealing a clearer picture 💻 3/5

Aging of blood system leads to health problems such as weakened immunity and a higher risk of anemia. Many of these changes can be traced back to HSCs, which reside in the bone marrow and renew all blood cells 🔬 2/5

There is no clear agreement on the effects of aging on HSCs, and how different types of HSCs play into this. So we pulled seven datasets together and re-analyzed them using new bioinformatic methods, revealing a clearer picture 3/5

Aging of blood system leads to health problems such as weakened immunity and a higher risk of anemia. Many of these changes can be traced back to HSCs, which reside in the bone marrow and renew all blood cells 2/5

Noted!

Congrats! Look forward to using it