Peter van Galen
@vangalenlab.bsky.social
We study how blood ages & how to improve leukemia treatment, using cell biology + bioinformatics — @mgbresearch @harvardmed @broadinstitute — https://vangalenlab.org
Exciting to see our latest story out in print — with @sandramcallister.bsky.social — on how breast cancer differs between younger and older patients, leading the way to tailored management to improve outcomes 💻🔬🧬🧪
November 6, 2025 at 1:00 PM
Exciting to see our latest story out in print — with @sandramcallister.bsky.social — on how breast cancer differs between younger and older patients, leading the way to tailored management to improve outcomes 💻🔬🧬🧪
These findings provide new insight into blood aging at the source, and raise the possibility of targeting inflammatory HSCs to "rejuvenate" blood production in aging 🧪
Thanks Ksenia Safina and collaborators @trowbridgelab.bsky.social @bloodgenes.bsky.social Read more at doi.org/10.1101/2025... 5/5🏁
Thanks Ksenia Safina and collaborators @trowbridgelab.bsky.social @bloodgenes.bsky.social Read more at doi.org/10.1101/2025... 5/5🏁
September 6, 2025 at 1:33 AM
These findings provide new insight into blood aging at the source, and raise the possibility of targeting inflammatory HSCs to "rejuvenate" blood production in aging 🧪
Thanks Ksenia Safina and collaborators @trowbridgelab.bsky.social @bloodgenes.bsky.social Read more at doi.org/10.1101/2025... 5/5🏁
Thanks Ksenia Safina and collaborators @trowbridgelab.bsky.social @bloodgenes.bsky.social Read more at doi.org/10.1101/2025... 5/5🏁
We discovered a type of stem cells that expand with age and is dominated by a program of inflammation and quiescence (GEP:1 below), which could leave the blood system less able to renew itself 📊 4/5
September 6, 2025 at 1:33 AM
We discovered a type of stem cells that expand with age and is dominated by a program of inflammation and quiescence (GEP:1 below), which could leave the blood system less able to renew itself 📊 4/5
There is no clear agreement on the effects of aging on HSCs, and how different types of HSCs play into this. So we pulled seven datasets together and re-analyzed them using new bioinformatic methods, revealing a clearer picture 💻 3/5
September 6, 2025 at 1:33 AM
There is no clear agreement on the effects of aging on HSCs, and how different types of HSCs play into this. So we pulled seven datasets together and re-analyzed them using new bioinformatic methods, revealing a clearer picture 💻 3/5
Aging of blood system leads to health problems such as weakened immunity and a higher risk of anemia. Many of these changes can be traced back to HSCs, which reside in the bone marrow and renew all blood cells 🔬 2/5
September 6, 2025 at 1:33 AM
Aging of blood system leads to health problems such as weakened immunity and a higher risk of anemia. Many of these changes can be traced back to HSCs, which reside in the bone marrow and renew all blood cells 🔬 2/5
Excited to share our latest work on blood aging! To find out why the blood system changes as people age, we started at the source: hematopoietic stem cells (HSCs) #hemesky 🩸🧬 doi.org/10.1101/2025... 🧵 1/5
September 6, 2025 at 1:33 AM
Excited to share our latest work on blood aging! To find out why the blood system changes as people age, we started at the source: hematopoietic stem cells (HSCs) #hemesky 🩸🧬 doi.org/10.1101/2025... 🧵 1/5
There is no clear agreement on the effects of aging on HSCs, and how different types of HSCs play into this. So we pulled seven datasets together and re-analyzed them using new bioinformatic methods, revealing a clearer picture 3/5
September 6, 2025 at 1:20 AM
There is no clear agreement on the effects of aging on HSCs, and how different types of HSCs play into this. So we pulled seven datasets together and re-analyzed them using new bioinformatic methods, revealing a clearer picture 3/5
Aging of blood system leads to health problems such as weakened immunity and a higher risk of anemia. Many of these changes can be traced back to HSCs, which reside in the bone marrow and renew all blood cells 2/5
September 6, 2025 at 1:20 AM
Aging of blood system leads to health problems such as weakened immunity and a higher risk of anemia. Many of these changes can be traced back to HSCs, which reside in the bone marrow and renew all blood cells 2/5
Online today! *Aging, Immune Fitness and Cancer* 🔬 Learn the latest about the intersection between these processes in
@natrevcancer.nature.com 🧬 Great to work with
@sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...
@natrevcancer.nature.com 🧬 Great to work with
@sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...
August 15, 2025 at 2:57 PM
Online today! *Aging, Immune Fitness and Cancer* 🔬 Learn the latest about the intersection between these processes in
@natrevcancer.nature.com 🧬 Great to work with
@sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...
@natrevcancer.nature.com 🧬 Great to work with
@sandramcallister.bsky.social lab again 😁 doi.org/10.1038/s415...
This may be my favorite paper of the year so far: integrating single-cell leukemia datasets to reveal how differentiation and mutations interact to drive disease, along with a tool that speeds up bone marrow cell annotation from ~4 weeks to ~4 hours..! aacrjournals.org/bloodcancerd... 🔬🩸🧬 #hemesky
August 5, 2025 at 10:46 PM
This may be my favorite paper of the year so far: integrating single-cell leukemia datasets to reveal how differentiation and mutations interact to drive disease, along with a tool that speeds up bone marrow cell annotation from ~4 weeks to ~4 hours..! aacrjournals.org/bloodcancerd... 🔬🩸🧬 #hemesky
Whenever the team @posit.co brings out a new feature, it’s exactly how I wished it would be. AI integration done right 🧠 positron.posit.co/assistant @anthropic.com
August 4, 2025 at 2:42 PM
Whenever the team @posit.co brings out a new feature, it’s exactly how I wished it would be. AI integration done right 🧠 positron.posit.co/assistant @anthropic.com
Had a great time catching up with friends and learning new science at FASEB Hematologic Malignancies! #hemesky @faseborg.bsky.social #HEMSRC
August 2, 2025 at 1:48 PM
Had a great time catching up with friends and learning new science at FASEB Hematologic Malignancies! #hemesky @faseborg.bsky.social #HEMSRC
Erasmus MC Hematology Lecture speaker lineup never fails to impress! #hemesky 🧪🩸 mcusercontent.com/71bcc0f3bb8a...
January 11, 2025 at 2:03 PM
Erasmus MC Hematology Lecture speaker lineup never fails to impress! #hemesky 🧪🩸 mcusercontent.com/71bcc0f3bb8a...
Just a reminder of what is easily in my top 5 of favorite papers from 2023 www.cell.com/iscience/ful... @bailee-kain.bsky.social @thekinglab.bsky.social
January 4, 2025 at 2:09 PM
Just a reminder of what is easily in my top 5 of favorite papers from 2023 www.cell.com/iscience/ful... @bailee-kain.bsky.social @thekinglab.bsky.social
Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...
December 23, 2024 at 12:54 PM
Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...
Boston’s North End ❄️
December 22, 2024 at 4:48 PM
Boston’s North End ❄️
Our new review “Insights into Leukemia from Single-Cell Genomics” is out! Great work by Nurefsan Sariipek @nursariipek.bsky.social 📝 www.annualreviews.org/content/jour... #hemesky 🩸🧬
December 16, 2024 at 2:52 PM
Our new review “Insights into Leukemia from Single-Cell Genomics” is out! Great work by Nurefsan Sariipek @nursariipek.bsky.social 📝 www.annualreviews.org/content/jour... #hemesky 🩸🧬
December 5, 2024 at 2:09 PM
...setting a transcript threshold that seems appropriate for blood progenitors will eliminate many T cell populations. This is illustrated in our MAESTER paper supplement pubmed.ncbi.nlm.nih.gov/35210612/ Thanks @sandramcallister.bsky.social for sending this along
3/3 #HemeSky 🩸 #GeneSky 🧬
3/3 #HemeSky 🩸 #GeneSky 🧬
December 4, 2024 at 2:55 PM
...setting a transcript threshold that seems appropriate for blood progenitors will eliminate many T cell populations. This is illustrated in our MAESTER paper supplement pubmed.ncbi.nlm.nih.gov/35210612/ Thanks @sandramcallister.bsky.social for sending this along
3/3 #HemeSky 🩸 #GeneSky 🧬
3/3 #HemeSky 🩸 #GeneSky 🧬
Interesting BMC Genomics paper filters "nucleus-free" low-quality cells using the number of intronic reads. MALAT1 expression may provide a shortcut, but I would be wary of filtering out meaningful data 1/3 🩸🧬 @tmontsay.bsky.social @annaesteveco.bsky.social www.ncbi.nlm.nih.gov/pubmed/39574...
December 4, 2024 at 2:55 PM
Interesting BMC Genomics paper filters "nucleus-free" low-quality cells using the number of intronic reads. MALAT1 expression may provide a shortcut, but I would be wary of filtering out meaningful data 1/3 🩸🧬 @tmontsay.bsky.social @annaesteveco.bsky.social www.ncbi.nlm.nih.gov/pubmed/39574...
For example, setting a transcript threshold that seems appropriate for blood cell progenitors will eliminate many T cell populations. This is illustrated in this figure from our MAESTER paper supplement pubmed.ncbi.nlm.nih.gov/35210612/ Thanks @sandramcallister.bsky.social for sending this along
3/3
3/3
December 4, 2024 at 2:33 PM
For example, setting a transcript threshold that seems appropriate for blood cell progenitors will eliminate many T cell populations. This is illustrated in this figure from our MAESTER paper supplement pubmed.ncbi.nlm.nih.gov/35210612/ Thanks @sandramcallister.bsky.social for sending this along
3/3
3/3
On Thanksgiving day, what is the effect of frequent blood donations? Donors may have a higher prevalence of EPO-responsive clonal hematopoiesis, but there is no increased risk for malignant clones, underscoring safety of repetitive blood donations. www.medrxiv.org/content/10.1... 🩸🧪 #hemesky
November 28, 2024 at 12:41 PM
On Thanksgiving day, what is the effect of frequent blood donations? Donors may have a higher prevalence of EPO-responsive clonal hematopoiesis, but there is no increased risk for malignant clones, underscoring safety of repetitive blood donations. www.medrxiv.org/content/10.1... 🩸🧪 #hemesky
Bad use case 🫠 (and reminder to carefully check everything ChatGPT generates)
November 18, 2024 at 9:01 PM
Bad use case 🫠 (and reminder to carefully check everything ChatGPT generates)
Not many papers change the way I think about AML, but this exceptional work shows how cell states and genetics intertwine to mediate venetoclax resistance, unifying previous studies by identifying RAS-mutated LSCs that are primed to produce myeloid cells #hemesky 🩸🧪 www.nature.com/articles/s41...
November 16, 2024 at 12:19 AM
Not many papers change the way I think about AML, but this exceptional work shows how cell states and genetics intertwine to mediate venetoclax resistance, unifying previous studies by identifying RAS-mutated LSCs that are primed to produce myeloid cells #hemesky 🩸🧪 www.nature.com/articles/s41...