@vagnarellilab.bsky.social
Reposted
The first paper from the Robson lab and a wonderful team effort with our international collaborators. Through a lot of detective work, we unravel an important artifact, Ab-trapping, that leads to profoundly misleading signal in both microscopy and genomics. Absolutely worth a read!
🚨 Preprint alert 🚨
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Excited to share our work on "Ab-trapping," an antibody artifact causing misleading peripheral ("rim") staining in imaging & genomics (IF, CUT&Tag, CUT&RUN). Antibodies fail to penetrate structures, accumulating at the periphery. A 🧵👇
doi.org/10.1101/2025...
Ab-trapping - a peripheral staining artifact in antibody-based microscopy and genomics
Antibodies (Ab) are essential for detecting specific epitopes in microscopy and genomics, but can produce artifacts leading to erroneous interpretations. Here, we characterize a novel artifact, Ab-tra...
doi.org
April 14, 2025 at 8:29 PM
The first paper from the Robson lab and a wonderful team effort with our international collaborators. Through a lot of detective work, we unravel an important artifact, Ab-trapping, that leads to profoundly misleading signal in both microscopy and genomics. Absolutely worth a read!
Reposted
Excited to announce the Emerging Innovators Fellowship for outstanding scientists of black heritage @mrc-lms.bsky.social
If you’re interested in applying & have a passion for cell cycle control or quiescence, do get in touch
Please circulate!
If you’re interested in applying & have a passion for cell cycle control or quiescence, do get in touch
Please circulate!
We’re thrilled to introduce our Emerging Innovators Fellowship, a new 3-year fully-funded postdoctoral fellowship designed to support scientists from Black heritage backgrounds.
Register now for our introductory Webinar on Tuesday 8th April at 9am!
Register now for our introductory Webinar on Tuesday 8th April at 9am!
LMS Emerging Innovators Fellowship Introductory Webinar
Join the LMS for an online session to learn more about our Emerging Innovators Fellowship for postdocs of Black heritage and how to apply
www.eventbrite.co.uk
April 3, 2025 at 3:12 PM
Excited to announce the Emerging Innovators Fellowship for outstanding scientists of black heritage @mrc-lms.bsky.social
If you’re interested in applying & have a passion for cell cycle control or quiescence, do get in touch
Please circulate!
If you’re interested in applying & have a passion for cell cycle control or quiescence, do get in touch
Please circulate!
Reposted
www.biorxiv.org/content/10.1...
A CDCA2 - MYC positive feedback loop controls cancer cells survival
Happy to share this new discovery of a link between CDCA2/PP1 and MYC.
Thanks @breastcancernow.bsky.social @Kidscan_UK for supporting the work
And all the coauthors who contributed over the years!
A CDCA2 - MYC positive feedback loop controls cancer cells survival
Happy to share this new discovery of a link between CDCA2/PP1 and MYC.
Thanks @breastcancernow.bsky.social @Kidscan_UK for supporting the work
And all the coauthors who contributed over the years!
www.biorxiv.org
March 1, 2025 at 8:45 AM
www.biorxiv.org/content/10.1...
A CDCA2 - MYC positive feedback loop controls cancer cells survival
Happy to share this new discovery of a link between CDCA2/PP1 and MYC.
Thanks @breastcancernow.bsky.social @Kidscan_UK for supporting the work
And all the coauthors who contributed over the years!
A CDCA2 - MYC positive feedback loop controls cancer cells survival
Happy to share this new discovery of a link between CDCA2/PP1 and MYC.
Thanks @breastcancernow.bsky.social @Kidscan_UK for supporting the work
And all the coauthors who contributed over the years!
www.biorxiv.org/content/10.1...
A CDCA2 - MYC positive feedback loop controls cancer cells survival
Happy to share this new discovery of a link between CDCA2/PP1 and MYC.
Thanks @breastcancernow.bsky.social @Kidscan_UK for supporting the work
And all the coauthors who contributed over the years!
A CDCA2 - MYC positive feedback loop controls cancer cells survival
Happy to share this new discovery of a link between CDCA2/PP1 and MYC.
Thanks @breastcancernow.bsky.social @Kidscan_UK for supporting the work
And all the coauthors who contributed over the years!
www.biorxiv.org
March 1, 2025 at 8:45 AM
www.biorxiv.org/content/10.1...
A CDCA2 - MYC positive feedback loop controls cancer cells survival
Happy to share this new discovery of a link between CDCA2/PP1 and MYC.
Thanks @breastcancernow.bsky.social @Kidscan_UK for supporting the work
And all the coauthors who contributed over the years!
A CDCA2 - MYC positive feedback loop controls cancer cells survival
Happy to share this new discovery of a link between CDCA2/PP1 and MYC.
Thanks @breastcancernow.bsky.social @Kidscan_UK for supporting the work
And all the coauthors who contributed over the years!
Many congratulations to Paulina Bryjka from the lab for winning the first Poster prize at the PGR research conference and to have managed to excite the entire College about the beauty of human centromeres. Such a proud supervisor!
January 25, 2025 at 2:05 PM
Many congratulations to Paulina Bryjka from the lab for winning the first Poster prize at the PGR research conference and to have managed to excite the entire College about the beauty of human centromeres. Such a proud supervisor!
Reposted
What pays off if the goal is to secure a faculty position in academia. Emphasises big papers and post-doc career rather than PhD. Not surprising but unfortunately puts even more emphasis on hitting a breakthrough paper rather than building persistently certain research direction.
More than 40 percent of #postdocs leave academia. Those who landed a coveted faculty position were more likely to have had a highly cited paper, changed their research topic between their #PhD and postdoc, or moved abroad after receiving their doctorate. www.pnas.org/doi/10.1073/... @pnas.org
More than 40% of postdocs leave academia, study reveals
Publishing highly cited papers helps postdoctoral researchers to land a faculty job.
www.nature.com
January 24, 2025 at 5:49 AM
What pays off if the goal is to secure a faculty position in academia. Emphasises big papers and post-doc career rather than PhD. Not surprising but unfortunately puts even more emphasis on hitting a breakthrough paper rather than building persistently certain research direction.
Reposted
Our fully 3D-printed microscope is featured in @newscientist.bsky.social www.newscientist.com/article/2462...
World’s first fully 3D-printed microscope made in under 3 hours
The microscope cost less than £50 to build using an open-source design and a common 3D printer
www.newscientist.com
January 10, 2025 at 9:44 PM
Our fully 3D-printed microscope is featured in @newscientist.bsky.social www.newscientist.com/article/2462...
Reposted
PhD studentship!
Chromatin! Structural Biology! Signaling! Stem Cells! Beautiful Devon!
Honestly, what more could you want?
APPLY NOW!
Deadline Friday 10 Jan!
@lsiexeter.bsky.social
Chromatin! Structural Biology! Signaling! Stem Cells! Beautiful Devon!
Honestly, what more could you want?
APPLY NOW!
Deadline Friday 10 Jan!
@lsiexeter.bsky.social
Fully funded #PhD Studentship with myself and JJ Phillips at the Living Systems Institute, @uniofexeter.bsky.social
"Control of chromatin remodeller activity to direct cell fate decisions"
#Chromatin #Transcription #StemCells #StructuralBiology
Please re-skeet!
www.exeter.ac.uk/research/ins...
"Control of chromatin remodeller activity to direct cell fate decisions"
#Chromatin #Transcription #StemCells #StructuralBiology
Please re-skeet!
www.exeter.ac.uk/research/ins...
LSI PhD programme | Living Systems Institute | University of Exeter
www.exeter.ac.uk
January 9, 2025 at 6:59 AM
PhD studentship!
Chromatin! Structural Biology! Signaling! Stem Cells! Beautiful Devon!
Honestly, what more could you want?
APPLY NOW!
Deadline Friday 10 Jan!
@lsiexeter.bsky.social
Chromatin! Structural Biology! Signaling! Stem Cells! Beautiful Devon!
Honestly, what more could you want?
APPLY NOW!
Deadline Friday 10 Jan!
@lsiexeter.bsky.social
Happy Holiday season to all friends, reviewers (even reviewer #3), colleagues trainees and support staff who contribute to make scientific discoveries still a wonderful dream... Happy discoveries for 2025!
December 24, 2024 at 3:36 PM
Happy Holiday season to all friends, reviewers (even reviewer #3), colleagues trainees and support staff who contribute to make scientific discoveries still a wonderful dream... Happy discoveries for 2025!
Many congratulations Dr Dorothee Kommer! Proud supervisor😊
Thanks to the external examiners Prof @viji-draviam.bsky.social, Dr Sally Wheatley and internal Dr Michell Sahai.
Thanks to the external examiners Prof @viji-draviam.bsky.social, Dr Sally Wheatley and internal Dr Michell Sahai.
December 18, 2024 at 6:16 PM
Many congratulations Dr Dorothee Kommer! Proud supervisor😊
Thanks to the external examiners Prof @viji-draviam.bsky.social, Dr Sally Wheatley and internal Dr Michell Sahai.
Thanks to the external examiners Prof @viji-draviam.bsky.social, Dr Sally Wheatley and internal Dr Michell Sahai.
Exciting few days ahead @CellBio2024. If you are around, come and meet us to hear some new developments on mitotic exit @vagnarellilab.bsky.social and H2A.Z in cell division
December 14, 2024 at 5:55 PM
Exciting few days ahead @CellBio2024. If you are around, come and meet us to hear some new developments on mitotic exit @vagnarellilab.bsky.social and H2A.Z in cell division
Reposted
Please RS/RT. #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup.
➡️Register now www.grc.org/histone-and-...
➡️Register now www.grc.org/histone-and-...
December 8, 2024 at 11:38 AM
Please RS/RT. #GordonConference on "Histone and DNA Modifications" #epigenetics #chromatin 20-25. July 2025. Il Ciocco, Italy. Great speaker lineup.
➡️Register now www.grc.org/histone-and-...
➡️Register now www.grc.org/histone-and-...
Reposted
Origin of Chromosome 12 Trisomy Surge in Human Induced Pluripotent Stem Cells (iPSCs) https://www.biorxiv.org/content/10.1101/2024.12.02.626470v1
Origin of Chromosome 12 Trisomy Surge in Human Induced Pluripotent Stem Cells (iPSCs) https://www.biorxiv.org/content/10.1101/2024.12.02.626470v1
Trisomy of chromosome 12 is the most common whole-chromosome abnormality found during culture of hum
www.biorxiv.org
December 3, 2024 at 6:30 AM
Origin of Chromosome 12 Trisomy Surge in Human Induced Pluripotent Stem Cells (iPSCs) https://www.biorxiv.org/content/10.1101/2024.12.02.626470v1
Reposted
and the clinical briefing www.nature.com/articles/d41...
Toxicity and costs of cancer treatment reduced by deferring CDK4/6 inhibitor use
No difference in survival outcomes between use of CDK4/6 inhibitors as first- or second-line treatment in metastatic breast cancer.
www.nature.com
November 28, 2024 at 8:57 AM
and the clinical briefing www.nature.com/articles/d41...
Reposted
🔊
We are recruiting PhD students and Postdocs!
We are seeking highly motivated, talented, and creative researchers, with strong background in cell and developmental biology, who are looking to spearhead original interdisciplinary investigations, addressing overlooked biology.
1/5
We are recruiting PhD students and Postdocs!
We are seeking highly motivated, talented, and creative researchers, with strong background in cell and developmental biology, who are looking to spearhead original interdisciplinary investigations, addressing overlooked biology.
1/5
November 30, 2024 at 5:55 PM
🔊
We are recruiting PhD students and Postdocs!
We are seeking highly motivated, talented, and creative researchers, with strong background in cell and developmental biology, who are looking to spearhead original interdisciplinary investigations, addressing overlooked biology.
1/5
We are recruiting PhD students and Postdocs!
We are seeking highly motivated, talented, and creative researchers, with strong background in cell and developmental biology, who are looking to spearhead original interdisciplinary investigations, addressing overlooked biology.
1/5
Reposted
I gladly bring this meeting to your attention so that you can mark dates in your calendar in case your are interest. Additional information will follow. Please circulate if possible.
November 17, 2024 at 11:52 AM
I gladly bring this meeting to your attention so that you can mark dates in your calendar in case your are interest. Additional information will follow. Please circulate if possible.
Reposted
Great news! If you're having trouble receiving strain orders in the EU there's a new European Distribution Hub!
community.alliancegenome.org/t/european-s...
community.alliancegenome.org/t/european-s...
European Shipping Hub
We are glad to announce the launch of the European Hub for CGC strain distribution. Since the pandemic, CGC shipments have become increasingly difficult to manage with higher costs, longer transit ti...
community.alliancegenome.org
November 21, 2024 at 7:22 AM
Great news! If you're having trouble receiving strain orders in the EU there's a new European Distribution Hub!
community.alliancegenome.org/t/european-s...
community.alliancegenome.org/t/european-s...