University of Minnesota Infectious Diseases
@umn-idim.bsky.social
Official account of the U of M Infectious Diseases and International Medicine Division.
Posting anything under the #IDSky 🦠🧫🧬🔬📚
Posting anything under the #IDSky 🦠🧫🧬🔬📚
New research from Dr. Debes:
In a Colombian cohort with Metabolic Associated Steatotic Liver Disease, the PNPLA3 risk allele was highly prevalent and strongly linked to advanced fibrosis and cirrhosis. Gene combinations also increased risk. #GISky
In a Colombian cohort with Metabolic Associated Steatotic Liver Disease, the PNPLA3 risk allele was highly prevalent and strongly linked to advanced fibrosis and cirrhosis. Gene combinations also increased risk. #GISky
Genetic Analysis of Metabolic-associated Steatosis Liver Disease in a Colombian Cohort
Numerous studies have identified genetic variations linked to the development and
progression of Metabolic Associated Steatosis Liver Disease (MASLD), but their relevance
is not completely understood ...
www.jcehepatology.com
November 15, 2025 at 1:19 PM
New research from Dr. Debes:
In a Colombian cohort with Metabolic Associated Steatotic Liver Disease, the PNPLA3 risk allele was highly prevalent and strongly linked to advanced fibrosis and cirrhosis. Gene combinations also increased risk. #GISky
In a Colombian cohort with Metabolic Associated Steatotic Liver Disease, the PNPLA3 risk allele was highly prevalent and strongly linked to advanced fibrosis and cirrhosis. Gene combinations also increased risk. #GISky
New research from Dr. Alon Herschhorn and team reveals a more efficient way to produce the HIV-1 gp120 protein, a key component for vaccine and viral entry studies. The stable cell line method yields 50× more protein than traditional approaches. #IDSky
Highly efficient production of HIV-1AD8 gp120 in mammalian cells | Journal of Virology
There are approximately 40.8 million people living with HIV-1 (PLWH) worldwide, with
an estimate of about 1.3 million new HIV-1 infections in 2024, highlighting the urgent
need for an effective HIV-1 ...
journals.asm.org
November 12, 2025 at 12:32 AM
New research from Dr. Alon Herschhorn and team reveals a more efficient way to produce the HIV-1 gp120 protein, a key component for vaccine and viral entry studies. The stable cell line method yields 50× more protein than traditional approaches. #IDSky
@nejm.org + @cidrap.bsky.social are launching Public Health Alerts — a new rapid-report platform to rival MMWR. Free, timely, and aimed at practitioners & researchers alike.
#IDSky
#IDSky
NEJM and public health group are launching rival to CDC’s MMWR publication
Two institutions are coming together to create an alternative to the CDC’s vaunted Morbidity and Mortality Weekly Report
www.statnews.com
November 10, 2025 at 1:33 PM
@nejm.org + @cidrap.bsky.social are launching Public Health Alerts — a new rapid-report platform to rival MMWR. Free, timely, and aimed at practitioners & researchers alike.
#IDSky
#IDSky
Mortality from advanced HIV disease remains high. The NIRVANA trial, led by Dr. Caleb Skipper and colleagues, tests whether treating CMV viraemia with valganciclovir can save lives. A phase 2b study now underway in Uganda and South Africa. #IDSky #Research
royalsocietypublishing.org
November 10, 2025 at 1:10 PM
What’s the optimal antibiotic duration after DAIR for acute periprosthetic joint infection (PJI)?
🌍 An international consensus led by ID faculty Dr. Geno Tai and colleagues recommends at least 12 weeks of therapy. #IDSky #MedSky #OrthoSky
🌍 An international consensus led by ID faculty Dr. Geno Tai and colleagues recommends at least 12 weeks of therapy. #IDSky #MedSky #OrthoSky
2025 ICM: Debridement, Antibiotics, and Implant Retention (DAIR)
James Cashman, Paul McCarroll, Peter Choong, Pedro Ivo Carvalho, Nicolaas Budhiparama,
Ewout S Veltman, David Dewar, Mehmet Kursat Yilmaz
www.arthroplastyjournal.org
November 9, 2025 at 2:53 PM
🌍 Diseases cross borders—and ID specialists need global skills to match.
Take our new online course: “Travel and Tropical Medicine for the Infectious Disease Specialist.”
🎓 30 CME credits
🧬 Prep for CTropMed®
📚 Interactive, case-based, flexible learning
#IDSky #MedSky
Take our new online course: “Travel and Tropical Medicine for the Infectious Disease Specialist.”
🎓 30 CME credits
🧬 Prep for CTropMed®
📚 Interactive, case-based, flexible learning
#IDSky #MedSky
GMED X900 Travel and Tropical Medicine for the Infectious Disease Specialist
learning.umn.edu
November 4, 2025 at 10:28 PM
New research from Dr. Susan Kline and colleagues shows that antibody levels after the Novavax (NVX-CoV2373) vaccine strongly predict protection against severe COVID-19. Higher neutralizing antibodies meant far fewer severe Delta infections.
#IDSky
academic.oup.com/cid/advance-...
#IDSky
academic.oup.com/cid/advance-...
Validate User
academic.oup.com
October 28, 2025 at 11:45 PM
New research from Dr. Susan Kline and colleagues shows that antibody levels after the Novavax (NVX-CoV2373) vaccine strongly predict protection against severe COVID-19. Higher neutralizing antibodies meant far fewer severe Delta infections.
#IDSky
academic.oup.com/cid/advance-...
#IDSky
academic.oup.com/cid/advance-...
We’re heading to #IDWeek2025!
Along with our colleagues at the Minnesota Department of Health and across the Twin Cities, we will be sharing:
📰 26 posters
🎤 12 symposiums
🗣️ 4 oral abstracts
🏆 1 plenary
We’re excited to showcase the incredible work coming out of Minnesota. See you there! #IDSky
Along with our colleagues at the Minnesota Department of Health and across the Twin Cities, we will be sharing:
📰 26 posters
🎤 12 symposiums
🗣️ 4 oral abstracts
🏆 1 plenary
We’re excited to showcase the incredible work coming out of Minnesota. See you there! #IDSky
October 19, 2025 at 4:54 PM
We’re heading to #IDWeek2025!
Along with our colleagues at the Minnesota Department of Health and across the Twin Cities, we will be sharing:
📰 26 posters
🎤 12 symposiums
🗣️ 4 oral abstracts
🏆 1 plenary
We’re excited to showcase the incredible work coming out of Minnesota. See you there! #IDSky
Along with our colleagues at the Minnesota Department of Health and across the Twin Cities, we will be sharing:
📰 26 posters
🎤 12 symposiums
🗣️ 4 oral abstracts
🏆 1 plenary
We’re excited to showcase the incredible work coming out of Minnesota. See you there! #IDSky
High CRP = high risk.
In a Ugandan cohort of 1,378 people with advanced HIV (CD4 ≤200), Dr. Boulware’s team found that CRP ≥10 mg/L predicted a 4× higher risk of hospitalization and 10× higher risk of death within 30 days. #IDSky
In a Ugandan cohort of 1,378 people with advanced HIV (CD4 ≤200), Dr. Boulware’s team found that CRP ≥10 mg/L predicted a 4× higher risk of hospitalization and 10× higher risk of death within 30 days. #IDSky
Predictive value of C-reactive protein for hospitalization and mortality among people with advanced HIV disease in Uganda receiving the WHO-recommended package of care
Among Ugandan outpatients with advanced HIV, elevated serum CRP (≥10 mg/L) predicted 30-day risk of opportunistic infection, hospitalization, and death. Ea
academic.oup.com
October 11, 2025 at 2:52 PM
High CRP = high risk.
In a Ugandan cohort of 1,378 people with advanced HIV (CD4 ≤200), Dr. Boulware’s team found that CRP ≥10 mg/L predicted a 4× higher risk of hospitalization and 10× higher risk of death within 30 days. #IDSky
In a Ugandan cohort of 1,378 people with advanced HIV (CD4 ≤200), Dr. Boulware’s team found that CRP ≥10 mg/L predicted a 4× higher risk of hospitalization and 10× higher risk of death within 30 days. #IDSky
🦠 Save the date!
Emerging Infections 2025
📍 Minneapolis, MN | 🗓️ Nov 21, 2025
Now in its 31st year, this conference cohosted by Mayo Clinic, the University of Minnesota, and MDH unites clinicians, laboratorians, and public health experts to tackle today’s emerging infectious threats. #IDSky
Emerging Infections 2025
📍 Minneapolis, MN | 🗓️ Nov 21, 2025
Now in its 31st year, this conference cohosted by Mayo Clinic, the University of Minnesota, and MDH unites clinicians, laboratorians, and public health experts to tackle today’s emerging infectious threats. #IDSky
October 9, 2025 at 10:51 AM
🦠 Save the date!
Emerging Infections 2025
📍 Minneapolis, MN | 🗓️ Nov 21, 2025
Now in its 31st year, this conference cohosted by Mayo Clinic, the University of Minnesota, and MDH unites clinicians, laboratorians, and public health experts to tackle today’s emerging infectious threats. #IDSky
Emerging Infections 2025
📍 Minneapolis, MN | 🗓️ Nov 21, 2025
Now in its 31st year, this conference cohosted by Mayo Clinic, the University of Minnesota, and MDH unites clinicians, laboratorians, and public health experts to tackle today’s emerging infectious threats. #IDSky
There’s now an app for all things fungi 🦠🍄
Dr. Matthew Pullen, Assistant Professor at the University of Minnesota, helped launch Dr Fungus—a free app that brings the trusted resource to your phone.
Explore fungal infections, antifungal treatments, and case-based learning—all in one place.
Dr. Matthew Pullen, Assistant Professor at the University of Minnesota, helped launch Dr Fungus—a free app that brings the trusted resource to your phone.
Explore fungal infections, antifungal treatments, and case-based learning—all in one place.
Home - Doctor Fungus
Welcome to Doctor Fungus! An Educational Website of theMycoses Study Group Education and Research Consortium (MSGERC) [View Legal Information] Where to Start Mycology Case of the Month An Introducti...
DrFungus.org
October 7, 2025 at 1:09 PM
There’s now an app for all things fungi 🦠🍄
Dr. Matthew Pullen, Assistant Professor at the University of Minnesota, helped launch Dr Fungus—a free app that brings the trusted resource to your phone.
Explore fungal infections, antifungal treatments, and case-based learning—all in one place.
Dr. Matthew Pullen, Assistant Professor at the University of Minnesota, helped launch Dr Fungus—a free app that brings the trusted resource to your phone.
Explore fungal infections, antifungal treatments, and case-based learning—all in one place.
Dr. Radha Rajasingham & Dr. Nathan Bahr explore this critical question in a new article. Their work highlights ongoing knowledge gaps around ART timing, antifungal regimens, and how to ensure treatments are effective, safe, and accessible worldwide. 🌍💊
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Can liposomal amphotericin B be used as a preventive measure for cryptococcal meningitis?
Published in Expert Review of Anti-infective Therapy (Just accepted, 2025)
www.tandfonline.com
October 3, 2025 at 11:56 AM
Dr. Radha Rajasingham & Dr. Nathan Bahr explore this critical question in a new article. Their work highlights ongoing knowledge gaps around ART timing, antifungal regimens, and how to ensure treatments are effective, safe, and accessible worldwide. 🌍💊
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
Dr. David Boulware’s latest study sheds light on the immune response in HIV-associated cryptococcal meningitis.
🧪 Early deaths were linked to immune exhaustion in cerebrospinal fluid cells. Low CD8+ T cells + higher PD-1 expression = higher risk. #IDSky
🧪 Early deaths were linked to immune exhaustion in cerebrospinal fluid cells. Low CD8+ T cells + higher PD-1 expression = higher risk. #IDSky
Cerebrospinal Fluid Mononuclear Cell Phenotype and Activation Predictors of 2-week and 1-year survival among Persons with HIV-Associated Cryptococcal Meningitis
AbstractBackground. Despite efforts to optimize therapy for HIV-associated cryptococcal meningitis (CM), survival outcomes remain poor. It is unclear how t
academic.oup.com
August 25, 2025 at 11:49 AM
Dr. David Boulware’s latest study sheds light on the immune response in HIV-associated cryptococcal meningitis.
🧪 Early deaths were linked to immune exhaustion in cerebrospinal fluid cells. Low CD8+ T cells + higher PD-1 expression = higher risk. #IDSky
🧪 Early deaths were linked to immune exhaustion in cerebrospinal fluid cells. Low CD8+ T cells + higher PD-1 expression = higher risk. #IDSky
🧠💉 Exciting news! Our faculty member Dr. Nathan Bahr co-authored the brand-new Clinical Practice Guideline for Tuberculous Meningitis. This work provides crucial recommendations for diagnosis & treatment of this devastating infection worldwide. #IDSky
A clinical practice guideline for tuberculous meningitis
Tuberculous meningitis is the most severe form of tuberculosis, causing death or disability
in around half of those affected. There are no up-to-date international guidelines
defining its optimal mana...
www.thelancet.com
August 23, 2025 at 7:00 PM
🧠💉 Exciting news! Our faculty member Dr. Nathan Bahr co-authored the brand-new Clinical Practice Guideline for Tuberculous Meningitis. This work provides crucial recommendations for diagnosis & treatment of this devastating infection worldwide. #IDSky
Cryptococcosis remains a leading cause of death in people with HIV. Dr. David Boulware’s FLOOR trial tested whether lower flucytosine dosing could keep treatment effective while reducing side effects. #IDSky
What is the correct dose of flucytosine in cryptococcal meningitis? 100mg/kg is a round number? Is it correct? We sought to test whether lower dose 60mg/kg x 10 days was equally effective. doi.org/10.1093/cid/...
Trial was designed by the great ID UMN fellow Tom McHale @umn-idim.bsky.social
Trial was designed by the great ID UMN fellow Tom McHale @umn-idim.bsky.social
August 11, 2025 at 2:58 PM
Cryptococcosis remains a leading cause of death in people with HIV. Dr. David Boulware’s FLOOR trial tested whether lower flucytosine dosing could keep treatment effective while reducing side effects. #IDSky
📅 Save the date: Sept 7–9, 2025
📍 Minneapolis, MN
Join us for the 2025 Congenital CMV Public Health & Policy Conference!
We’ll cover diagnosis, treatment, prevention, and family support. Our goal? Fewer babies born with CMV—and better lives for those affected.
#CMV #PublicHealth #IDSky
📍 Minneapolis, MN
Join us for the 2025 Congenital CMV Public Health & Policy Conference!
We’ll cover diagnosis, treatment, prevention, and family support. Our goal? Fewer babies born with CMV—and better lives for those affected.
#CMV #PublicHealth #IDSky
CMV Conference
cmv.usu.edu
July 31, 2025 at 2:10 PM
📅 Save the date: Sept 7–9, 2025
📍 Minneapolis, MN
Join us for the 2025 Congenital CMV Public Health & Policy Conference!
We’ll cover diagnosis, treatment, prevention, and family support. Our goal? Fewer babies born with CMV—and better lives for those affected.
#CMV #PublicHealth #IDSky
📍 Minneapolis, MN
Join us for the 2025 Congenital CMV Public Health & Policy Conference!
We’ll cover diagnosis, treatment, prevention, and family support. Our goal? Fewer babies born with CMV—and better lives for those affected.
#CMV #PublicHealth #IDSky
Faculty Dr. William M. Stauffer co-led the 2025 International Refugee and Migration Health Conference in Halifax—bringing together 600+ global leaders to address health equity for displaced people. 🧵#IDSky
The Halifax Declaration: protecting health, dignity, and human rights in an era of forced displacement
www.sciencedirect.com
July 30, 2025 at 2:00 PM
Faculty Dr. William M. Stauffer co-led the 2025 International Refugee and Migration Health Conference in Halifax—bringing together 600+ global leaders to address health equity for displaced people. 🧵#IDSky
🚨 New National Guidelines Alert!
Our very own Dr. Dimitri Drekonja together with colleagues just authored the IDSA guidelines for urinary tract infections.
ID expertise from the University of Minnesota helping shape clinical care nationwide. 💪💊 #IDSky #UMNproud #UTI #MedSky #InfectiousDiseases
Our very own Dr. Dimitri Drekonja together with colleagues just authored the IDSA guidelines for urinary tract infections.
ID expertise from the University of Minnesota helping shape clinical care nationwide. 💪💊 #IDSky #UMNproud #UTI #MedSky #InfectiousDiseases
Complicated Urinary Tract Infections (cUTI): Clinical Guidelines for Treatment and Management
www.idsociety.org
July 26, 2025 at 5:00 PM
🚨 New National Guidelines Alert!
Our very own Dr. Dimitri Drekonja together with colleagues just authored the IDSA guidelines for urinary tract infections.
ID expertise from the University of Minnesota helping shape clinical care nationwide. 💪💊 #IDSky #UMNproud #UTI #MedSky #InfectiousDiseases
Our very own Dr. Dimitri Drekonja together with colleagues just authored the IDSA guidelines for urinary tract infections.
ID expertise from the University of Minnesota helping shape clinical care nationwide. 💪💊 #IDSky #UMNproud #UTI #MedSky #InfectiousDiseases
✨ #FollowFriday ✨
We’re so close to 4,000 followers! Help us get there by tapping that follow button and tagging a colleague who should be part of our community. 🧫🌍🧠
Grateful for all of you who make this space smarter, kinder, and more curious. #IDSky #MedSky
We’re so close to 4,000 followers! Help us get there by tapping that follow button and tagging a colleague who should be part of our community. 🧫🌍🧠
Grateful for all of you who make this space smarter, kinder, and more curious. #IDSky #MedSky
June 27, 2025 at 11:37 AM
✨ #FollowFriday ✨
We’re so close to 4,000 followers! Help us get there by tapping that follow button and tagging a colleague who should be part of our community. 🧫🌍🧠
Grateful for all of you who make this space smarter, kinder, and more curious. #IDSky #MedSky
We’re so close to 4,000 followers! Help us get there by tapping that follow button and tagging a colleague who should be part of our community. 🧫🌍🧠
Grateful for all of you who make this space smarter, kinder, and more curious. #IDSky #MedSky
🧠📈 New research from @drboulware.bsky.social @natebahrid.bsky.social
In people with TB meningitis (a serious brain infection), high levels of inflammation in the blood were linked to worse recovery.
A simple blood test (CRP) could help doctors predict who’s at higher risk early on. #IDSky
In people with TB meningitis (a serious brain infection), high levels of inflammation in the blood were linked to worse recovery.
A simple blood test (CRP) could help doctors predict who’s at higher risk early on. #IDSky
Prognostic Value of C-Reactive Protein in Adults With Tuberculous Meningitis: A Prospective Cohort Study
Among a cohort of adults with tuberculous meningitis, including 83% living with human immunodeficiency virus, we found that baseline C-reactive protein ≥40
academic.oup.com
June 27, 2025 at 11:30 AM
🧠📈 New research from @drboulware.bsky.social @natebahrid.bsky.social
In people with TB meningitis (a serious brain infection), high levels of inflammation in the blood were linked to worse recovery.
A simple blood test (CRP) could help doctors predict who’s at higher risk early on. #IDSky
In people with TB meningitis (a serious brain infection), high levels of inflammation in the blood were linked to worse recovery.
A simple blood test (CRP) could help doctors predict who’s at higher risk early on. #IDSky
Dr. Lokensgard and his team just made a fascinating discovery: certain immune cells called bTRMs stay in the brain after a viral infection and quietly keep the virus from waking up again. When these cells were removed in mice, the virus started to stir. #IDSky
www.mdpi.com
June 17, 2025 at 12:39 PM
Dr. Lokensgard and his team just made a fascinating discovery: certain immune cells called bTRMs stay in the brain after a viral infection and quietly keep the virus from waking up again. When these cells were removed in mice, the virus started to stir. #IDSky
🌲🔥 Our former ID fellow led a powerful study linking wildfire smoke and COVID-19 outcomes in California during 2020.
Climate change isn't just an environmental crisis—it’s an infectious diseases one too. 🌍🦠 #IDSky
Climate change isn't just an environmental crisis—it’s an infectious diseases one too. 🌍🦠 #IDSky
Spatiotemporal Association of Coronavirus Disease 2019 Cases and Deaths With Exposure to Wildfire Particulate Matter in 2020
In 2020 wildfires in California were particularly severe as the COVID-19 pandemic emerged. Wildfire particulate matter was spatially and temporally associa
academic.oup.com
June 16, 2025 at 1:02 PM
🌲🔥 Our former ID fellow led a powerful study linking wildfire smoke and COVID-19 outcomes in California during 2020.
Climate change isn't just an environmental crisis—it’s an infectious diseases one too. 🌍🦠 #IDSky
Climate change isn't just an environmental crisis—it’s an infectious diseases one too. 🌍🦠 #IDSky
How common is Valley fever really? A new study by faculty Dr. Bahr and colleagues estimates over 273,000 symptomatic cases of coccidioidomycosis in 2019—up to 18x higher than what’s reported nationally. Most cases are missed or misdiagnosed. #ValleyFever #PublicHealth #IDSky
Estimated Burden of Coccidioidomycosis
This cross-sectional study generates a systematic and rigorous estimate of national incident symptomatic coccidioidomycosis cases by developing a model to account for cases missed through national sur...
jamanetwork.com
June 9, 2025 at 10:40 PM
How common is Valley fever really? A new study by faculty Dr. Bahr and colleagues estimates over 273,000 symptomatic cases of coccidioidomycosis in 2019—up to 18x higher than what’s reported nationally. Most cases are missed or misdiagnosed. #ValleyFever #PublicHealth #IDSky
Can early changes in COVID-19 viral load predict serious outcomes? 🧬 Dr. Boulware and team led the first individual participant data meta-analysis to find out! They pooled data from 23 trials to tackle this key question for Phase 2 clinical trials. #IDSky
The choice of viral load endpoint in early phase trials of COVID-19 treatments aiming to reduce 28-day hospitalization and/or death
This meta-analysis uses individual participant data to evaluate various SARS-CoV-2 viral load outcomes as surrogates for 28-day hospitalization/death. Chan
academic.oup.com
June 7, 2025 at 4:37 PM
Can early changes in COVID-19 viral load predict serious outcomes? 🧬 Dr. Boulware and team led the first individual participant data meta-analysis to find out! They pooled data from 23 trials to tackle this key question for Phase 2 clinical trials. #IDSky
🧠🔬 Grand Rounds Spotlight
Drs. Caleb Skipper and Mark Schleiss delivering a powerful discussion on the life-course implications of Cytomegalovirus (CMV) — a virus that continues to reveal its complexity far beyond the contexts of pregnancy or immunocompromised populations. #IDSky
Drs. Caleb Skipper and Mark Schleiss delivering a powerful discussion on the life-course implications of Cytomegalovirus (CMV) — a virus that continues to reveal its complexity far beyond the contexts of pregnancy or immunocompromised populations. #IDSky
May 16, 2025 at 9:53 PM
🧠🔬 Grand Rounds Spotlight
Drs. Caleb Skipper and Mark Schleiss delivering a powerful discussion on the life-course implications of Cytomegalovirus (CMV) — a virus that continues to reveal its complexity far beyond the contexts of pregnancy or immunocompromised populations. #IDSky
Drs. Caleb Skipper and Mark Schleiss delivering a powerful discussion on the life-course implications of Cytomegalovirus (CMV) — a virus that continues to reveal its complexity far beyond the contexts of pregnancy or immunocompromised populations. #IDSky