Triona Ní Chonghaile
@ttclab.bsky.social
The goal of the Targeted Therapeutics in Cancer lab is to kill cancer cells. Our research interests include mitochondrial apoptosis, epigenetics, and metabolism.
Reposted by Triona Ní Chonghaile
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT
Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...
www.science.org
November 6, 2025 at 7:01 PM
1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A fantastic viewpoint by @frezzalab.bsky.social network.febs.org/posts/thinki...
It reminds me of the lampost-and-key analogy described in this article by Michael Yaffe www.science.org/doi/10.1126/....
The goal is to understand network-based signalling.
It reminds me of the lampost-and-key analogy described in this article by Michael Yaffe www.science.org/doi/10.1126/....
The goal is to understand network-based signalling.
November 4, 2025 at 12:18 PM
A fantastic viewpoint by @frezzalab.bsky.social network.febs.org/posts/thinki...
It reminds me of the lampost-and-key analogy described in this article by Michael Yaffe www.science.org/doi/10.1126/....
The goal is to understand network-based signalling.
It reminds me of the lampost-and-key analogy described in this article by Michael Yaffe www.science.org/doi/10.1126/....
The goal is to understand network-based signalling.
Reposted by Triona Ní Chonghaile
Congratulations to the recipients of the Nobel Prize in Physiology or Medicine 2025 - Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance" including the identification of regulatory T cells
#NobelPrize #Tregs
@nobelprize.bsky.social 🧪🔬🏆
#NobelPrize #Tregs
@nobelprize.bsky.social 🧪🔬🏆
October 6, 2025 at 11:00 AM
Congratulations to the recipients of the Nobel Prize in Physiology or Medicine 2025 - Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance" including the identification of regulatory T cells
#NobelPrize #Tregs
@nobelprize.bsky.social 🧪🔬🏆
#NobelPrize #Tregs
@nobelprize.bsky.social 🧪🔬🏆
Reposted by Triona Ní Chonghaile
🏆 Congratulations to our Director, Prof @dchenshall.bsky.social, on receiving the ILAE Ambassador for Epilepsy Award at the 36th International Epilepsy Congress in Lisbon—recognising his global impact on epilepsy research.
@ilae-epilepsy.bsky.social @researchireland.ie @epilepsyireland.bsky.social
@ilae-epilepsy.bsky.social @researchireland.ie @epilepsyireland.bsky.social
September 1, 2025 at 8:08 AM
🏆 Congratulations to our Director, Prof @dchenshall.bsky.social, on receiving the ILAE Ambassador for Epilepsy Award at the 36th International Epilepsy Congress in Lisbon—recognising his global impact on epilepsy research.
@ilae-epilepsy.bsky.social @researchireland.ie @epilepsyireland.bsky.social
@ilae-epilepsy.bsky.social @researchireland.ie @epilepsyireland.bsky.social
Reposted by Triona Ní Chonghaile
Cells swapping their #mitochondria - this sounded like science fiction 🧪 when the first studies started coming out!
But now this has been observed in #cancer, #yeast, #molluscs, and under normal physiology - as a way to regulate energy demands, metabolism, cell fate & much more - true #powerhouses!
But now this has been observed in #cancer, #yeast, #molluscs, and under normal physiology - as a way to regulate energy demands, metabolism, cell fate & much more - true #powerhouses!
Cells are swapping their mitochondria. What does this mean for our health?
Researchers are studying why the energy factories are moving between cells and whether the process can be harnessed to treat cancer and other diseases.
www.nature.com
September 1, 2025 at 2:03 PM
Cells swapping their #mitochondria - this sounded like science fiction 🧪 when the first studies started coming out!
But now this has been observed in #cancer, #yeast, #molluscs, and under normal physiology - as a way to regulate energy demands, metabolism, cell fate & much more - true #powerhouses!
But now this has been observed in #cancer, #yeast, #molluscs, and under normal physiology - as a way to regulate energy demands, metabolism, cell fate & much more - true #powerhouses!
Huge congratulations to Andy on the publication of his PhD work! This was a massive team effort, thanks to the lab for helping out & collaborators: Ingmar Schoen, Emmar Kerr @mariemcilroy.bsky.social
Link here:
www.nature.com/articles/s41.... Thanks to funding from @researchireland.ie
Link here:
www.nature.com/articles/s41.... Thanks to funding from @researchireland.ie
Inhibition of HDAC6 alters fumarate hydratase activity and mitochondrial structure - Nature Communications
Here they show that HDAC6 inhibition regulates fumarate hydratase (FH), disrupts mitochondria, increases fumarate, and causes cancer cell death. This suggests that HDAC6 inhibition could be a strategy...
www.nature.com
July 29, 2025 at 9:22 AM
Huge congratulations to Andy on the publication of his PhD work! This was a massive team effort, thanks to the lab for helping out & collaborators: Ingmar Schoen, Emmar Kerr @mariemcilroy.bsky.social
Link here:
www.nature.com/articles/s41.... Thanks to funding from @researchireland.ie
Link here:
www.nature.com/articles/s41.... Thanks to funding from @researchireland.ie
Very excited about the first Irish Multiple Myeloma Meeting being held this September 12th!! Mark the calendars it should be a great meeting.
May 8, 2025 at 9:18 AM
Very excited about the first Irish Multiple Myeloma Meeting being held this September 12th!! Mark the calendars it should be a great meeting.
Reposted by Triona Ní Chonghaile
ApoList – April 2025 – Articles on apoptosis and cell death
With several articles about how mRNA splicing problems cause necroptosis by zDNA,
and about different outcomes of macrophages phagocytising apoptotic cells of different cell types (efferocytosis)
celldeath.wordpress.com/2025/05/06/a...
With several articles about how mRNA splicing problems cause necroptosis by zDNA,
and about different outcomes of macrophages phagocytising apoptotic cells of different cell types (efferocytosis)
celldeath.wordpress.com/2025/05/06/a...
ApoList – April 2025
Bcl-2 family proteins Structural basis of BAK sequestration by MCL-1 in apoptosis Shagun Srivastava, Giridhar Sekar, Adedolapo Ojoawo, Anup Aggarwal, Elisabeth Ferreira, Emiko Uchikawa, Meek Yang, …
celldeath.wordpress.com
May 6, 2025 at 1:41 PM
ApoList – April 2025 – Articles on apoptosis and cell death
With several articles about how mRNA splicing problems cause necroptosis by zDNA,
and about different outcomes of macrophages phagocytising apoptotic cells of different cell types (efferocytosis)
celldeath.wordpress.com/2025/05/06/a...
With several articles about how mRNA splicing problems cause necroptosis by zDNA,
and about different outcomes of macrophages phagocytising apoptotic cells of different cell types (efferocytosis)
celldeath.wordpress.com/2025/05/06/a...
Congratulations to Dr. Ludovica Di Martino @rcsi.bsky.social for receiving the Prof. John Fitzpatrick award at the IACR meeting for her presentation on Multiple Myeloma. We celebrated with delicious Italian treats! Thanks to collaborator Prof. Siobhan Glavey @Beaumont RCSI Cancer Centre.
March 11, 2025 at 11:34 AM
Congratulations to Dr. Ludovica Di Martino @rcsi.bsky.social for receiving the Prof. John Fitzpatrick award at the IACR meeting for her presentation on Multiple Myeloma. We celebrated with delicious Italian treats! Thanks to collaborator Prof. Siobhan Glavey @Beaumont RCSI Cancer Centre.
Reposted by Triona Ní Chonghaile
Thrilled our review was selected as a #science #highlight in this #Cell timeline of the last decade 🧪
"Embracing #cancer complexity: Hallmarks of systemic disease"
Swanton et al, 2024
www.sciencedirect.com/science/arti...
@charlesswanton.bsky.social
@cancerresearchuk.org
@cp-cell.bsky.social
"Embracing #cancer complexity: Hallmarks of systemic disease"
Swanton et al, 2024
www.sciencedirect.com/science/arti...
@charlesswanton.bsky.social
@cancerresearchuk.org
@cp-cell.bsky.social
January 27, 2025 at 1:00 PM
Thrilled our review was selected as a #science #highlight in this #Cell timeline of the last decade 🧪
"Embracing #cancer complexity: Hallmarks of systemic disease"
Swanton et al, 2024
www.sciencedirect.com/science/arti...
@charlesswanton.bsky.social
@cancerresearchuk.org
@cp-cell.bsky.social
"Embracing #cancer complexity: Hallmarks of systemic disease"
Swanton et al, 2024
www.sciencedirect.com/science/arti...
@charlesswanton.bsky.social
@cancerresearchuk.org
@cp-cell.bsky.social
Huge congratulations to the newly minted Dr. Andy Roe on his viva 🎉!! Thanks so much to examiners @crismunozp.bsky.social and Dr. Niamh Connolly (not on Blue sky!) and the chair @christophertorrens.bsky.social @rcsi.bsky.social @rcsi-research.bsky.social. Looking forward to following your 💫 career.
December 12, 2024 at 9:01 PM
Huge congratulations to the newly minted Dr. Andy Roe on his viva 🎉!! Thanks so much to examiners @crismunozp.bsky.social and Dr. Niamh Connolly (not on Blue sky!) and the chair @christophertorrens.bsky.social @rcsi.bsky.social @rcsi-research.bsky.social. Looking forward to following your 💫 career.
An interesting paper just published in Nature on HDAC6 as a valine sensor:
rdcu.be/d1waX
rdcu.be/d1waX
Human HDAC6 senses valine abundancy to regulate DNA damage
Nature - The histone deacetylase HDAC6 is a sensor of valine levels, and the abundance of valine in cells regulates DNA damage and cell homeostasis functions.
rdcu.be
November 26, 2024 at 1:10 PM
An interesting paper just published in Nature on HDAC6 as a valine sensor:
rdcu.be/d1waX
rdcu.be/d1waX
Reposted by Triona Ní Chonghaile
Our perspective in Science Magazine on #Ferroptosis—#disease perils and #therapeutic promise www.science.org/doi/10.1126/... written for a general audience -- not too technical. Congrats to authors Ashley Brown and Tal Hirschhorn!
Ferroptosis—disease perils and therapeutic promise
Mechanisms of iron-dependent cell death reveal potential new targets for disease treatment
www.science.org
November 22, 2024 at 2:48 AM
Our perspective in Science Magazine on #Ferroptosis—#disease perils and #therapeutic promise www.science.org/doi/10.1126/... written for a general audience -- not too technical. Congrats to authors Ashley Brown and Tal Hirschhorn!
Reposted by Triona Ní Chonghaile
Unfortunately, we have to postpone tomorrow’s webinar with Emma Farley. We will reschedule as soon as we can!
Nice to see all you chromatin & epigenetics aficionados here! As we build our network back up please repost details for our upcoming webinar this Friday!
We are delighted to welcome Emma Farley for her webinar 'Dependency Grammar of Developmental Enhancers' on November 22nd. Registration below 👇
We are delighted to welcome Emma Farley for her webinar 'Dependency Grammar of Developmental Enhancers' on November 22nd. Registration below 👇
November 21, 2024 at 5:09 PM
Unfortunately, we have to postpone tomorrow’s webinar with Emma Farley. We will reschedule as soon as we can!