Abhishek Trivedi
@trivedi09.bsky.social
Post-doc@ASU. Worked on T9SS. Gliding motility. Rotary motor and M.tb Biofilms.
Reposted by Abhishek Trivedi
'Congress has your back': US senators tell scientists they want to protect NIH budget
->Nature | #Science | More info from EcoSearch
->Nature | #Science | More info from EcoSearch
'Congress has your back': US senators tell scientists they want to protect NIH budget
Attendees at a meeting of a US Senate appropriations committee on 31 July: from left, Patty Murray, a Democrat from Washington state; Susan Collins, a Republican from Maine; and Mitch McConnell, a Republican from Kentucky.Credit: Tom Williams/CQ-Roll Call via Getty...
www.nature.com
August 2, 2025 at 1:38 AM
Reposted by Abhishek Trivedi
🄰🅆🄴🅂🄾🄼🄴
Stubbusch et al 𝘚𝘊𝘐𝘌𝘕𝘊𝘌
Bacteria 🦠 repurpose Type VI Secretion Systems based on environmental cues:
Nutrient-rich environments ➜ kill competitors
Under starvation ➜ lyse neighbors to scavenge their nutrients
Even “non-pathogens” shift from competition to predation as a survival strategy
Stubbusch et al 𝘚𝘊𝘐𝘌𝘕𝘊𝘌
Bacteria 🦠 repurpose Type VI Secretion Systems based on environmental cues:
Nutrient-rich environments ➜ kill competitors
Under starvation ➜ lyse neighbors to scavenge their nutrients
Even “non-pathogens” shift from competition to predation as a survival strategy
Antagonism as a foraging strategy in microbial communities
In natural habitats, nutrient availability limits bacterial growth. We discovered that bacteria can overcome this limitation by acquiring nutrients by lysing neighboring cells through contact-dependen...
www.science.org
June 14, 2025 at 4:37 AM
🄰🅆🄴🅂🄾🄼🄴
Stubbusch et al 𝘚𝘊𝘐𝘌𝘕𝘊𝘌
Bacteria 🦠 repurpose Type VI Secretion Systems based on environmental cues:
Nutrient-rich environments ➜ kill competitors
Under starvation ➜ lyse neighbors to scavenge their nutrients
Even “non-pathogens” shift from competition to predation as a survival strategy
Stubbusch et al 𝘚𝘊𝘐𝘌𝘕𝘊𝘌
Bacteria 🦠 repurpose Type VI Secretion Systems based on environmental cues:
Nutrient-rich environments ➜ kill competitors
Under starvation ➜ lyse neighbors to scavenge their nutrients
Even “non-pathogens” shift from competition to predation as a survival strategy
Did you know some bacteria can move by spinning tiny motors embedded in their outer membrane? These motors are part of the Type 9 Secretion System (T9SS), which helps them glide and secrete proteins. 🚶♂️🦠
June 13, 2025 at 9:14 PM
Did you know some bacteria can move by spinning tiny motors embedded in their outer membrane? These motors are part of the Type 9 Secretion System (T9SS), which helps them glide and secrete proteins. 🚶♂️🦠
We identified a switch protein that controls the rotational direction of the bacterial T9SS motor a molecular gear shift in Flavobacterium
A molecular conveyor belt-associated protein controls the rotational direction of the bacterial type 9 secretion system | mBio journals.asm.org/doi/full/10....
A molecular conveyor belt-associated protein controls the rotational direction of the bacterial type 9 secretion system | mBio journals.asm.org/doi/full/10....
A molecular conveyor belt-associated protein controls the rotational direction of the bacterial type 9 secretion system | mBio
The type 9 secretion system (T9SS) is fundamental to bacterial gliding motility, pathogenesis, and surface colonization. Our findings reveal that the C-terminal region of the conveyor belt-associated protein GldJ functions as a molecular switch which is ...
journals.asm.org
June 13, 2025 at 9:07 PM
We identified a switch protein that controls the rotational direction of the bacterial T9SS motor a molecular gear shift in Flavobacterium
A molecular conveyor belt-associated protein controls the rotational direction of the bacterial type 9 secretion system | mBio journals.asm.org/doi/full/10....
A molecular conveyor belt-associated protein controls the rotational direction of the bacterial type 9 secretion system | mBio journals.asm.org/doi/full/10....
Reposted by Abhishek Trivedi
Krista Freeman et al 𝘊𝘌𝘓𝘓
stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm
can inform precise targeted phage therapies for TB and NTM infections
www.cell.com/cell/fulltex...
stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm
can inform precise targeted phage therapies for TB and NTM infections
www.cell.com/cell/fulltex...
April 18, 2025 at 10:33 AM
Krista Freeman et al 𝘊𝘌𝘓𝘓
stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm
can inform precise targeted phage therapies for TB and NTM infections
www.cell.com/cell/fulltex...
stunning atomic-level imaging (Cryo-EM, cryo-ET) reveals how 𝐛𝐚𝐜𝐭𝐞𝐫𝐢𝐨𝐩𝐡𝐚𝐠𝐞 Bxb1 reshapes its tail tip to breach the mycobacterial cell wall and deliver DNA to the cytoplasm
can inform precise targeted phage therapies for TB and NTM infections
www.cell.com/cell/fulltex...
Reposted by Abhishek Trivedi
The link provides access to the article for another 2 weeks before a paywall goes up. Use it or lose it.
🔬🦠 How to make sense of the taxonomic complexity & interpersonal variability of the gut microbiota? We propose that beneath this complexity lies a hierarchy of factors that control gut microbiota assembly. Read more! #Microbiome #GutHealth
authors.elsevier.com/a/1km32_,2Ci...
authors.elsevier.com/a/1km32_,2Ci...
March 24, 2025 at 4:06 AM
The link provides access to the article for another 2 weeks before a paywall goes up. Use it or lose it.
U.S. early-career researchers struggling amid chaos | Science | AAAS www.science.org/content/arti...
U.S. early-career researchers struggling amid chaos
Uncertain funding, government firings, and distressed universities hit vulnerable groups especially hard
www.science.org
February 22, 2025 at 6:10 AM
U.S. early-career researchers struggling amid chaos | Science | AAAS www.science.org/content/arti...
Reposted by Abhishek Trivedi
ATTENTION (PLEASE SHARE)
If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.
There are lots of talented and accomplished people who may be looking for new opportunities.
If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.
There are lots of talented and accomplished people who may be looking for new opportunities.
a poster that says if life gives you lemon make lemonade on it
ALT: a poster that says if life gives you lemon make lemonade on it
media.tenor.com
February 15, 2025 at 3:37 PM
ATTENTION (PLEASE SHARE)
If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.
There are lots of talented and accomplished people who may be looking for new opportunities.
If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.
There are lots of talented and accomplished people who may be looking for new opportunities.
Reposted by Abhishek Trivedi
Deeply saddened by the passing of Prof. Mike Sheetz, a true leader in Mechanobiology. His groundbreaking work on Kinesin, membrane organization, and mechanotransduction has left an indelible mark. A tremendous loss to science. #Mechanobiology #Science #LaskerAward
February 1, 2025 at 11:29 AM
Deeply saddened by the passing of Prof. Mike Sheetz, a true leader in Mechanobiology. His groundbreaking work on Kinesin, membrane organization, and mechanotransduction has left an indelible mark. A tremendous loss to science. #Mechanobiology #Science #LaskerAward
Reposted by Abhishek Trivedi
OUT NOW: KorB is a DNA clamp which slides along DNA to mediate long-range gene silencing upon interaction with the clamp-locking KorA protein
by Tung Le & co @johninnescentre.bsky.social
www.nature.com/articles/s41...
by Tung Le & co @johninnescentre.bsky.social
www.nature.com/articles/s41...
KorB switching from DNA-sliding clamp to repressor mediates long-range gene silencing in a multi-drug resistance plasmid - Nature Microbiology
Structural and single-molecule analyses show the CTPase, KorB, is a sliding DNA clamp that interacts with a clamp-locking protein KorA to inhibit gene expression over distances of more than 1 kb in th...
www.nature.com
January 23, 2025 at 10:58 AM
OUT NOW: KorB is a DNA clamp which slides along DNA to mediate long-range gene silencing upon interaction with the clamp-locking KorA protein
by Tung Le & co @johninnescentre.bsky.social
www.nature.com/articles/s41...
by Tung Le & co @johninnescentre.bsky.social
www.nature.com/articles/s41...
Reposted by Abhishek Trivedi
Do you know who Douglas Prasher is? Many don't, even though he is the person who cloned the original #GFP gene in the late 1980s. In my short history of plant light #microscopy I also cover a bit of his story - & why he is relatively unknown today, despite the importance of his work. See this 🧵👇
May 20, 2024 at 2:19 PM
Do you know who Douglas Prasher is? Many don't, even though he is the person who cloned the original #GFP gene in the late 1980s. In my short history of plant light #microscopy I also cover a bit of his story - & why he is relatively unknown today, despite the importance of his work. See this 🧵👇