ton rabelink
@trabelink.bsky.social
Ex vivo preservation of donor kidneys is crucial to improve transplant outcomes—and may allow future organ repair. But the challenge remains: how to preserve function for longer periods?
July 29, 2025 at 5:17 AM
Ex vivo preservation of donor kidneys is crucial to improve transplant outcomes—and may allow future organ repair. But the challenge remains: how to preserve function for longer periods?
Reposted by ton rabelink
Kidney transplantation is the only definitive treatment for end-stage kidney disease. This article explores challenges in renal replacement and highlights the clinical potential of bioengineering approaches to restore kidney function:
Replacing renal function using bioengineered tissues - Nature Reviews Bioengineering
Renal function can be replaced by bioengineered kidney tissue. This Review discusses in vivo kidney engineering, xenotransplantation, blastocyst complementation and stem-cell-derived kidney tissue engineering as approaches for renal replacement therapy.
go.nature.com
May 24, 2025 at 2:20 PM
Kidney transplantation is the only definitive treatment for end-stage kidney disease. This article explores challenges in renal replacement and highlights the clinical potential of bioengineering approaches to restore kidney function:
Reposted by ton rabelink
In a new preprint with @trabelink.bsky.social, T. Moritz & @bonalditiziana.bsky.social, we find that implantation leads to rewiring of the TCA cycle to support histone acetylation turnover and exit from naïve pluripotency. Gr8 work of @elenikafkia.bsky.social D. Pladevall-Morera et al. rb.gy/clk8vm
TCA cycle rewiring underpins implantation and histone acetylation programming
Metabolism has emerged as a key regulator of stem cell differentiation and their epigenomes. This coupling is particularly evident during the exit from naive pluripotency in vitro. However, our unders...
rb.gy
April 29, 2025 at 7:54 AM
In a new preprint with @trabelink.bsky.social, T. Moritz & @bonalditiziana.bsky.social, we find that implantation leads to rewiring of the TCA cycle to support histone acetylation turnover and exit from naïve pluripotency. Gr8 work of @elenikafkia.bsky.social D. Pladevall-Morera et al. rb.gy/clk8vm