Organ perfusion is entering a promising but complex era. Addressing injury mechanisms like ferroptosis is key to safe, longer preservation.
#transplant #kidney #research #biomedicine

This raises questions about RBC-based strategies. In a joint perspective (Schneeberger et al.) we outline ideas to move forward and avoid these injury pathways.
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However, our group (Marlon de Haan et al.) shows in the same journal that ferroptosis is a key injury mechanism during perfusion—especially when red blood cells (RBCs) are used.
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A recent study in Nature Communications by Richard Dumbill et al. shows normothermic perfusion is feasible for 6+ hours.
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