Eric Brooks
@tomorrowbot.bsky.social
Developmental biologist interested in how morphogenesis is encoded in space and time. Microscope lover. Mets fan.
Reposted by Eric Brooks
Cilia Alert! So excited to finally have this paper on the CPLANE complex out in @natcomms.nature.com! We show that RSG1 is a human ciliopathy protein and links CPLANE to the transition zone. 1/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The human ciliopathy protein RSG1 links the CPLANE complex to transition zone architecture - Nature Communications
The CPLANE complex is essential for ciliogenesis, and mutations to all but one subunit have been associated with ciliopathies. Here they identify three familial mutations in the final subunit, RSG1, t...
www.nature.com
July 1, 2025 at 5:22 PM
Cilia Alert! So excited to finally have this paper on the CPLANE complex out in @natcomms.nature.com! We show that RSG1 is a human ciliopathy protein and links CPLANE to the transition zone. 1/n
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Eric Brooks
A look at the developing human embryonic forebrain in 3D!
Post-doc @stochastalive.bsky.social shares this week's image showing a dorsal view of the human embryonic forebrain at Carnegie Stage 16 (~6 weeks post conception). Major regions marked by FOXG1, WNT8B, PAX6, and SHH are displayed.
Post-doc @stochastalive.bsky.social shares this week's image showing a dorsal view of the human embryonic forebrain at Carnegie Stage 16 (~6 weeks post conception). Major regions marked by FOXG1, WNT8B, PAX6, and SHH are displayed.
June 11, 2025 at 4:54 PM
A look at the developing human embryonic forebrain in 3D!
Post-doc @stochastalive.bsky.social shares this week's image showing a dorsal view of the human embryonic forebrain at Carnegie Stage 16 (~6 weeks post conception). Major regions marked by FOXG1, WNT8B, PAX6, and SHH are displayed.
Post-doc @stochastalive.bsky.social shares this week's image showing a dorsal view of the human embryonic forebrain at Carnegie Stage 16 (~6 weeks post conception). Major regions marked by FOXG1, WNT8B, PAX6, and SHH are displayed.
Reposted by Eric Brooks
Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data"
A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making
Applied to ventral neural tube development
www.biorxiv.org/content/10.1...
A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making
Applied to ventral neural tube development
www.biorxiv.org/content/10.1...
Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data
Building a mechanistic understanding of cell fate decisions remains a fundamental goal of developmental biology, with implications for stem cell therapies, regenerative medicine and understanding dise...
www.biorxiv.org
May 29, 2025 at 12:08 PM
Our latest "Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data"
A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making
Applied to ventral neural tube development
www.biorxiv.org/content/10.1...
A rigorous mathematical foundation for Waddington's landscape to study cell fate decision making
Applied to ventral neural tube development
www.biorxiv.org/content/10.1...
Reposted by Eric Brooks
#ApicalConstriction and #DevBio afficionados - we've got two new pre-prints you may be interested in, below:
May 20, 2025 at 2:30 PM
#ApicalConstriction and #DevBio afficionados - we've got two new pre-prints you may be interested in, below:
Congrats on the big year, Ben!
WOW! Been a crazy busy year but we've gotten a lot of stuff across the finish line. All the credit to my team here at U of L and our collabs at IU SOM, Oxford, CU Anschutz and UC Merced! Gonna update y'all with this Bluetorial!
May 6, 2025 at 8:57 PM
Congrats on the big year, Ben!
Reposted by Eric Brooks
WOW! Been a crazy busy year but we've gotten a lot of stuff across the finish line. All the credit to my team here at U of L and our collabs at IU SOM, Oxford, CU Anschutz and UC Merced! Gonna update y'all with this Bluetorial!
May 6, 2025 at 5:57 PM
WOW! Been a crazy busy year but we've gotten a lot of stuff across the finish line. All the credit to my team here at U of L and our collabs at IU SOM, Oxford, CU Anschutz and UC Merced! Gonna update y'all with this Bluetorial!
Reposted by Eric Brooks
The "Biological Differentiation Across the Scales" virtual seminar series kicked off on April 28 with an insightful, engaging talk by @ecbrooks96.bsky.social. Missed it live? Watch the recording: www.isdifferentiation.org/Journal/Page... @rogerslabucd.bsky.social @uribelab.bsky.social #devbio
May 6, 2025 at 3:07 PM
The "Biological Differentiation Across the Scales" virtual seminar series kicked off on April 28 with an insightful, engaging talk by @ecbrooks96.bsky.social. Missed it live? Watch the recording: www.isdifferentiation.org/Journal/Page... @rogerslabucd.bsky.social @uribelab.bsky.social #devbio
We are pleased to share the version of record of our study on the complex role of Wnt signaling in control of cell behavior during cranial neural tube closure. This work was spearheaded by the fantastic Amber Bogart and is out now in @devbiol.bsky.social www.sciencedirect.com/science/arti...
Canonical Wnt pathway modulation is required to correctly execute multiple independent cellular dynamic programs during cranial neural tube closure
Defects in cranial neural tube closure are among the most common and deleterious human structural birth defects. Correct cranial closure requires the …
www.sciencedirect.com
April 28, 2025 at 5:23 PM
We are pleased to share the version of record of our study on the complex role of Wnt signaling in control of cell behavior during cranial neural tube closure. This work was spearheaded by the fantastic Amber Bogart and is out now in @devbiol.bsky.social www.sciencedirect.com/science/arti...
Reposted by Eric Brooks
A gorgeous (first of many!) paper out of the Brooks Lab (@tomorrowbot.bsky.social): www.sciencedirect.com/science/arti...
Neural tube closure! Wnt signaling! Cell proliferation! Quantitative microscopy! What’s not to love?
Neural tube closure! Wnt signaling! Cell proliferation! Quantitative microscopy! What’s not to love?
Canonical Wnt pathway modulation is required to correctly execute multiple independent cellular dynamic programs during cranial neural tube closure
Defects in cranial neural tube closure are among the most common and deleterious human structural birth defects. Correct cranial closure requires the …
www.sciencedirect.com
April 28, 2025 at 1:11 AM
A gorgeous (first of many!) paper out of the Brooks Lab (@tomorrowbot.bsky.social): www.sciencedirect.com/science/arti...
Neural tube closure! Wnt signaling! Cell proliferation! Quantitative microscopy! What’s not to love?
Neural tube closure! Wnt signaling! Cell proliferation! Quantitative microscopy! What’s not to love?
Reposted by Eric Brooks
A new 2D gene expression map of the mouse brain during early development.
Mapping brain development
A new study provides a two-dimensional gene expression map during early brain development.
elifesciences.org
April 12, 2025 at 3:21 AM
A new 2D gene expression map of the mouse brain during early development.
Reposted by Eric Brooks
Join us for the @socdevbio.bsky.social Southeast Regional Meeting, May 19-21! www.sdbonline.org/sesdb2025 Showcase your exciting research & receive valuable feedback at any stage, from a newly fertilized idea to a rapidly gastrulating hypothesis to a fully 'developed' story. 🙂 #SESDB2025 #DevBio
April 8, 2025 at 11:46 PM
Join us for the @socdevbio.bsky.social Southeast Regional Meeting, May 19-21! www.sdbonline.org/sesdb2025 Showcase your exciting research & receive valuable feedback at any stage, from a newly fertilized idea to a rapidly gastrulating hypothesis to a fully 'developed' story. 🙂 #SESDB2025 #DevBio
Excited to share the version of record of our study of patterned gene expression during the earliest stages of neural development, out now in @elife.bsky.social! A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate doi.org/10.7554/eLif...
A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate
Single-cell RNA sequencing and computational analysis define a spatial and temporal map of gene expression during early patterning and morphogenesis of the mouse cranial neural plate, providing a reso...
doi.org
April 7, 2025 at 10:54 PM
Excited to share the version of record of our study of patterned gene expression during the earliest stages of neural development, out now in @elife.bsky.social! A single-cell atlas of spatial and temporal gene expression in the mouse cranial neural plate doi.org/10.7554/eLif...
My daily haiku from grant writing:
More words fall beneath
The stoke of my delete key
Concision triumphs
More words fall beneath
The stoke of my delete key
Concision triumphs
January 17, 2025 at 1:14 AM
My daily haiku from grant writing:
More words fall beneath
The stoke of my delete key
Concision triumphs
More words fall beneath
The stoke of my delete key
Concision triumphs
Reposted by Eric Brooks
A new single-cell atlas of gene expression provides insights into the patterning of the neural plate of mice.
🔗 https://elifesciences.org/articles/105042?utm_source=bluesky&utm_medium=social&utm_campaign=organic_insights
🔗 https://elifesciences.org/articles/105042?utm_source=bluesky&utm_medium=social&utm_campaign=organic_insights
January 7, 2025 at 2:59 PM
A new single-cell atlas of gene expression provides insights into the patterning of the neural plate of mice.
🔗 https://elifesciences.org/articles/105042?utm_source=bluesky&utm_medium=social&utm_campaign=organic_insights
🔗 https://elifesciences.org/articles/105042?utm_source=bluesky&utm_medium=social&utm_campaign=organic_insights
Pleased to present the first preprint from our group, spearheaded by the fantastic Amber Bogart. We examined the consequences of either reduced or hyperactivated Want signaling on the cellular drivers of cranial closure. www.biorxiv.org/content/10.1...
Wnt pathway modulation is required to correctly execute multiple independent cellular dynamic programs during cranial neural tube closure
Defects in cranial neural tube closure are among the most common and deleterious human structural birth defects. Correct cranial closure requires the coordination of multiple cell dynamic programs inc...
www.biorxiv.org
December 20, 2024 at 5:01 PM
Pleased to present the first preprint from our group, spearheaded by the fantastic Amber Bogart. We examined the consequences of either reduced or hyperactivated Want signaling on the cellular drivers of cranial closure. www.biorxiv.org/content/10.1...