Tobi Alegbe
@tobioinformatics.bsky.social
I look at small things on a big scale
Single-cell data scientist at Open Targets, EMBL-EBI. Previously StatGen PhD student at Sanger Institute
Single-cell data scientist at Open Targets, EMBL-EBI. Previously StatGen PhD student at Sanger Institute
Pinned
🚨New preprint just dropped 🚨
medrxiv.org/content/10.1101/2025.06.24.25330216
The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!
medrxiv.org/content/10.1101/2025.06.24.25330216
The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!
Reposted by Tobi Alegbe
Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
Sperm sequencing reveals extensive positive selection in the male germline - Nature
A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.
www.nature.com
October 8, 2025 at 3:51 PM
Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...
Reposted by Tobi Alegbe
Happy to share that this work together with @opentargets.org is now out at Nature Communications.
Out now in Nature Comms: the largest trans-eQTL meta-analysis in a single cell type!
An Open Targets team led by Krista Freimann and @kauralasoo.bsky.social analysed 3,734 lymphoblastoid cell line samples across nine cohorts, identifying four robust loci
www.nature.com/articles/s41...
An Open Targets team led by Krista Freimann and @kauralasoo.bsky.social analysed 3,734 lymphoblastoid cell line samples across nine cohorts, identifying four robust loci
www.nature.com/articles/s41...
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus - Nature Communications | Open Targets
Out now in Nature Comms: the largest trans-eQTL meta-analysis in a single cell type!
An Open Targets team led by Krista Freimann and Kaur Alasoo analysed 3,734 lymphoblastoid cell line samples across...
www.linkedin.com
October 2, 2025 at 1:05 PM
Happy to share that this work together with @opentargets.org is now out at Nature Communications.
Reposted by Tobi Alegbe
Scientists have uncovered hidden genetic drivers of conditions like IBD by stimulating immune cells. 🔬
The findings have resulted in a dataset called MacroMap, which offers insight into why some people are vulnerable to certain conditions.
sanger.ac.uk/news_item/ac...
The findings have resulted in a dataset called MacroMap, which offers insight into why some people are vulnerable to certain conditions.
sanger.ac.uk/news_item/ac...
Activated immune cells reveal hidden drivers of autoimmune diseases
A new resource, MacroMap, provides a rich dataset that researchers can use to explore genetic mechanisms behind complex diseases.
sanger.ac.uk
August 27, 2025 at 9:43 AM
Scientists have uncovered hidden genetic drivers of conditions like IBD by stimulating immune cells. 🔬
The findings have resulted in a dataset called MacroMap, which offers insight into why some people are vulnerable to certain conditions.
sanger.ac.uk/news_item/ac...
The findings have resulted in a dataset called MacroMap, which offers insight into why some people are vulnerable to certain conditions.
sanger.ac.uk/news_item/ac...
🚨New preprint just dropped 🚨
medrxiv.org/content/10.1101/2025.06.24.25330216
The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!
medrxiv.org/content/10.1101/2025.06.24.25330216
The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!
July 8, 2025 at 8:52 AM
🚨New preprint just dropped 🚨
medrxiv.org/content/10.1101/2025.06.24.25330216
The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!
medrxiv.org/content/10.1101/2025.06.24.25330216
The main output from my PhD is finally public and we’re SUPER excited about the findings! If you’re interested in what we learnt about IBD with a massive 700+ sample sc-eQTL dataset of the gut, read on!
An awesome preprint by a superstar PhD student looking at the utility of blood vs tissue in the context of disease!
🚨 SUPER EXCITED to share our new preprint on the mucosal and circulatory immune landscape of Crohn’s disease!
🩸 Blood is commonly used in biomarker discovery and drug development, but how well does it reflect what's actually happening in the gut? 👀
🧵 1/10
🔗 www.medrxiv.org/content/10.1...
🩸 Blood is commonly used in biomarker discovery and drug development, but how well does it reflect what's actually happening in the gut? 👀
🧵 1/10
🔗 www.medrxiv.org/content/10.1...
Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn's disease
Crohn's disease (CD) is a heterogeneous disease characterized by chronic inflammation of the gastrointestinal tract driven by an aberrant immune response. To understand the immune mechanisms underlyin...
www.medrxiv.org
June 5, 2025 at 8:39 AM
An awesome preprint by a superstar PhD student looking at the utility of blood vs tissue in the context of disease!
Reposted by Tobi Alegbe
🚨 SUPER EXCITED to share our new preprint on the mucosal and circulatory immune landscape of Crohn’s disease!
🩸 Blood is commonly used in biomarker discovery and drug development, but how well does it reflect what's actually happening in the gut? 👀
🧵 1/10
🔗 www.medrxiv.org/content/10.1...
🩸 Blood is commonly used in biomarker discovery and drug development, but how well does it reflect what's actually happening in the gut? 👀
🧵 1/10
🔗 www.medrxiv.org/content/10.1...
Tissue-specific and circulatory immune signatures of mucosal inflammation in Crohn's disease
Crohn's disease (CD) is a heterogeneous disease characterized by chronic inflammation of the gastrointestinal tract driven by an aberrant immune response. To understand the immune mechanisms underlyin...
www.medrxiv.org
June 4, 2025 at 8:02 PM
🚨 SUPER EXCITED to share our new preprint on the mucosal and circulatory immune landscape of Crohn’s disease!
🩸 Blood is commonly used in biomarker discovery and drug development, but how well does it reflect what's actually happening in the gut? 👀
🧵 1/10
🔗 www.medrxiv.org/content/10.1...
🩸 Blood is commonly used in biomarker discovery and drug development, but how well does it reflect what's actually happening in the gut? 👀
🧵 1/10
🔗 www.medrxiv.org/content/10.1...
Reposted by Tobi Alegbe
Heading to #EMDS24 in 🇦🇹 this week?
Come hear about our work on the "inflammatory handbrake" exerted by intestinal monocytes in human IBD and murine colitis through ACOD1.
Wednesday, Session 4 1640-55; See you there!
www.biorxiv.org/content/10.1...
Come hear about our work on the "inflammatory handbrake" exerted by intestinal monocytes in human IBD and murine colitis through ACOD1.
Wednesday, Session 4 1640-55; See you there!
www.biorxiv.org/content/10.1...
November 27, 2024 at 8:07 AM
Heading to #EMDS24 in 🇦🇹 this week?
Come hear about our work on the "inflammatory handbrake" exerted by intestinal monocytes in human IBD and murine colitis through ACOD1.
Wednesday, Session 4 1640-55; See you there!
www.biorxiv.org/content/10.1...
Come hear about our work on the "inflammatory handbrake" exerted by intestinal monocytes in human IBD and murine colitis through ACOD1.
Wednesday, Session 4 1640-55; See you there!
www.biorxiv.org/content/10.1...