Thiago J Borges, PhD
@tjborges.bsky.social
Transplant biologist and immunologist | Instructor
@MGHSurgery @mgh_transplant @HarvardMed. Posts are my own
@MGHSurgery @mgh_transplant @HarvardMed. Posts are my own
Pinned
The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell–mediated transplant rejection
Siglec-E negatively regulates innate immune responses and acute T cell–mediated transplant rejection in mice, offering a potential therapeutic target.
www.science.org
🚨 Our new study in @SciTranslMed identified the inhibitory receptor Siglec-E as a critical brake on dendritic cell activation and T cell–mediated transplant rejection. 1/4
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
🚨 Our new study in @SciTranslMed identified the inhibitory receptor Siglec-E as a critical brake on dendritic cell activation and T cell–mediated transplant rejection. 1/4
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The inhibitory receptor Siglec-E controls antigen-presenting cell activation and T cell–mediated transplant rejection
Siglec-E negatively regulates innate immune responses and acute T cell–mediated transplant rejection in mice, offering a potential therapeutic target.
www.science.org
May 7, 2025 at 8:46 PM
🚨 Our new study in @SciTranslMed identified the inhibitory receptor Siglec-E as a critical brake on dendritic cell activation and T cell–mediated transplant rejection. 1/4
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
🚨 Great Opportunity! 🚨
The Riella Lab, at the Mass General Hospital, is seeking a Postdoc in Transplant Immunology with expertise in Microsurgery.
📍 Apply now! #Postdoc #Microsurgery #TransplantResearch
The Riella Lab, at the Mass General Hospital, is seeking a Postdoc in Transplant Immunology with expertise in Microsurgery.
📍 Apply now! #Postdoc #Microsurgery #TransplantResearch
March 6, 2025 at 10:22 PM
🚨 Great Opportunity! 🚨
The Riella Lab, at the Mass General Hospital, is seeking a Postdoc in Transplant Immunology with expertise in Microsurgery.
📍 Apply now! #Postdoc #Microsurgery #TransplantResearch
The Riella Lab, at the Mass General Hospital, is seeking a Postdoc in Transplant Immunology with expertise in Microsurgery.
📍 Apply now! #Postdoc #Microsurgery #TransplantResearch
Reposted by Thiago J Borges, PhD
Presented at #ISNWCN:
A new report describes the transplantation of a gene-edited porcine kidney in a hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access challenges. Read the full report: nej.md/3Esayoz
@theisn.org
A new report describes the transplantation of a gene-edited porcine kidney in a hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access challenges. Read the full report: nej.md/3Esayoz
@theisn.org
Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease | NEJM
Xenotransplantation offers a potential solution to the organ shortage crisis. A 62-year-old
hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and
marked dialysis-access...
nej.md
February 7, 2025 at 4:15 PM
Presented at #ISNWCN:
A new report describes the transplantation of a gene-edited porcine kidney in a hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access challenges. Read the full report: nej.md/3Esayoz
@theisn.org
A new report describes the transplantation of a gene-edited porcine kidney in a hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access challenges. Read the full report: nej.md/3Esayoz
@theisn.org
Reposted by Thiago J Borges, PhD
Cardiac allograft tolerance can be achieved in nonhuman primates by donor bone marrow and kidney cotransplantation | Science Translational Medicine www.science.org/doi/10.1126/...
Cardiac allograft tolerance can be achieved in nonhuman primates by donor bone marrow and kidney cotransplantation
Combining transient mixed chimerism with kidney cotransplantation achieves heart allograft tolerance in nonhuman primates.
www.science.org
January 22, 2025 at 8:04 PM
Cardiac allograft tolerance can be achieved in nonhuman primates by donor bone marrow and kidney cotransplantation | Science Translational Medicine www.science.org/doi/10.1126/...
Reposted by Thiago J Borges, PhD
Review
@sciimmunology.bsky.social
DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer
science.org/doi/10.1126/...
@sciimmunology.bsky.social
DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer
science.org/doi/10.1126/...
January 17, 2025 at 9:55 PM
Review
@sciimmunology.bsky.social
DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer
science.org/doi/10.1126/...
@sciimmunology.bsky.social
DC–T cell interactions during priming influence CD8+ T cell fate, and DCs subsequently sustain T cell responses against cancer
science.org/doi/10.1126/...
Reposted by Thiago J Borges, PhD
A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity
@scienceimmuno.bsky.social @enfuhui.bsky.social
www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @enfuhui.bsky.social
www.science.org/doi/10.1126/...
Functional differences between rodent and human PD-1 linked to evolutionary divergence
A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity.
www.science.org
January 3, 2025 at 7:34 PM
A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity
@scienceimmuno.bsky.social @enfuhui.bsky.social
www.science.org/doi/10.1126/...
@scienceimmuno.bsky.social @enfuhui.bsky.social
www.science.org/doi/10.1126/...
Reposted by Thiago J Borges, PhD
Dysregulated Treg repair responses lead to chronic rejection after heart transplantation
www.jci.org/articles/vie...
www.jci.org/articles/vie...
December 3, 2024 at 7:08 PM
Dysregulated Treg repair responses lead to chronic rejection after heart transplantation
www.jci.org/articles/vie...
www.jci.org/articles/vie...
Great opportunity! I learned a lot from the experience
👇🏼👇🏼👇🏼👇🏼
👇🏼👇🏼👇🏼👇🏼
Interested in learning more about the editorial and review process for manuscript submissions? The #AmericanJournalofTransplantation is accepting fellow applications now- see link 👇
www.amjtransplant.com/fellowship [amjtransplant.com]
Accepting applications December 1 - January 15, 2025.
www.amjtransplant.com/fellowship [amjtransplant.com]
Accepting applications December 1 - January 15, 2025.
www.amjtransplant.com
December 3, 2024 at 1:23 AM
Great opportunity! I learned a lot from the experience
👇🏼👇🏼👇🏼👇🏼
👇🏼👇🏼👇🏼👇🏼
Reposted by Thiago J Borges, PhD
The hypoimmune mouse (MHC-deletion, CD47 overexpression) and all of its organs are completely invisible to allogeneic immune cells
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
November 29, 2024 at 7:58 PM
The hypoimmune mouse (MHC-deletion, CD47 overexpression) and all of its organs are completely invisible to allogeneic immune cells
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...