timasaki.bsky.social
@timasaki.bsky.social
Reposted
Our latest work is out in biorxiv! 😊

We show that human spastin, a microtubule severing enzyme, behaves completely differently in presence of free tubulin - it forms tubulin ring stack and promotes de novo microtubule nucleation.

www.biorxiv.org/content/10.1...
Human spastin functions as an ATPase-independent microtubule nucleator via ring-stack formation
Microtubule severing enzyme spastin plays pivotal roles in cytokinesis and neuronal outgrowth, and its mutations cause hereditary spastic paraplegia (HSP). Here we show that, at physiological tubulin ...
www.biorxiv.org
December 1, 2025 at 8:20 AM
Reposted
Excited to share our work on archaeal 3D genome! This paper revealed how an archaeal SMC complex sculpts TAD-like domains by cooperating with a roadblock NAP and physical properties of DNA. Many congrats to our talented PhD student Kodai!
www.nature.com/articles/s41...
Chromosomal domain formation by archaeal SMC, a roadblock protein, and DNA structure - Nature Communications
Eukaryotic chromosomes are organized into arrays of compact domain structures called TADs. Here the authors show that a member of the Archaea, the prokaryotic domain closest to the Eukarya, uses a euk...
www.nature.com
February 19, 2025 at 12:20 PM
Reposted
ワシントンの悲劇的な飛行機事故を受けて、トランプは「ぜんぶ多様性が悪いんだ、航空局が障害者を雇ったからだ!」などと、人類史の汚点と呼ぶにふさわしい信じがたい暴言をさっそく発しているが、むしろお前のせいだろ説が濃厚に。

「注目すべきは、トランプ政権が1月20日に発足すると、連邦政府職員の解雇を迅速に開始したため、連邦航空局の指導部には空席が点在していることだ。」記事より

まぁまだ事故の細かい原因は不明なので保留だが、仮にこの見方が正しいとして、悪政によってここまで迅速に、最悪の形で「結果が出て」しまうことがあるとは…。
www.theguardian.com/us-news/2025...
Trump blames others but Washington air crash comes amid upheaval in US aviation
More flights, staffing shortages and mounting safety questions may have played a role in deadly air collision
www.theguardian.com
January 31, 2025 at 1:08 AM
秒でフォローバックされた
December 6, 2024 at 10:22 AM