👉 To conclude, we show that condensin I physically and functionally interacts with PiggyMac, thus highlighting a strong interaction between the two machineries.

🧬 We demonstrate that this new development-specific complex is essential for DNA elimination and the establishment of H3K9me3 & H3K27me3 patterns during development, fully phenocopying PiggyMac depletion.

🧪Using TurboID proximity labelling, we identified condensin I subunits among the closest interactors of the PiggyMac endonuclease, leading to the identification of a development-specific condensin I complex

I add an amazing time last week at the Epigenetics 2025 meeting from the @gensocuk.bsky.social in sunny Belfast! Great discussions and insights on my PhD project! Also very honored to have been awarded the best poster prize!