A titanic effort from Seda and the lab in collaboration with Nuria Flames’ lab ‪@sedakoyuncu.bsky.social‬ @unicologne.bsky.social‬ @cecad.bsky.social‬ ‪@ibv-csic.bsky.social‬ ‪@nataging.nature.com‬‬‬‬‬‬

We also discovered that the deubiquitinase USP4 leads to EPS8 accumulation during aging.
Reducing USP4 prevented EPS8 accumulation, extended lifespan, and lessened disease effects.
👉 Targeting EPS8/USP4 could open new therapeutic strategies for neurodegeneration.

In C. elegans & human cells, we found that age-related EPS8/RAC signaling hyperactivation promotes pathological aggregation of fifferent proteins (polyQ, FUS, TDP-43).
Decreasing EPS8 (or tuning RAC signaling) prevents aggregation & and neurodegeneration.

I was just wondering the same thing, given the number of recent papers along these lines

Hi Dani, I would really appreciate it if you can add me to the Science feed:
www.davidvilchezlab.com
scholar.google.com/citations?us...

The project will be carried out at the CECAD Research Center (University of Cologne): @unicologne.bsky.social @uniklinikkoeln.bsky.social @cecad.bsky.social

🤪🤪🤪🤪🤪🤪🤪🤪🤪

Felicidades!

Thanks Barak😉

The study is part of the CRC1678 consortium;) @crc1678.bsky.social