David Vilchez
@thevilchezlab.bsky.social
Biologist, Professor at CECAD, University of Cologne.
We study aging, age-related diseases, stem cell biology and proteostasis.
http://www.davidvilchezlab.com/
We study aging, age-related diseases, stem cell biology and proteostasis.
http://www.davidvilchezlab.com/
Saygin’s new ALS paper — showing nucleoporin alterations — just made the journal front cover @febsletters.bsky.social febs.onlinelibrary.wiley.com/doi/10.1002/...
febs.onlinelibrary.wiley.com/doi/10.1002/...
febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
Cover illustration Stress granules in iPSCs treated with arsenite (G3BP1 (green) / NUP107 (red) / Hoechst (nucleus)). Image credit: Saygin Bilican. The image refers to Bilican et al., “C9orf72 ALS-ca....
febs.onlinelibrary.wiley.com
November 10, 2025 at 7:29 PM
Saygin’s new ALS paper — showing nucleoporin alterations — just made the journal front cover @febsletters.bsky.social febs.onlinelibrary.wiley.com/doi/10.1002/...
febs.onlinelibrary.wiley.com/doi/10.1002/...
febs.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by David Vilchez
🚨Check out this new study from our Research Unit member @bjornschumacher.bsky.social on gene expression patterns linked to age deceleration and rejuvenation during Dauer Diapause. Congratulations! 🎉
🚀 🚀 🚀 Our latest paper is out now: Age Deceleration and Reversal Gene Patterns in Dauer Diapause. We can learn from nature how aging of a whole organism with completely differentiated tissues can be slowed and how that organism can be completely rejuvenated.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Age Deceleration and Reversal Gene Patterns in Dauer Diapause
The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d...
onlinelibrary.wiley.com
October 20, 2025 at 8:28 AM
🚨Check out this new study from our Research Unit member @bjornschumacher.bsky.social on gene expression patterns linked to age deceleration and rejuvenation during Dauer Diapause. Congratulations! 🎉
Reposted by David Vilchez
www.cell.com/cell/abstrac...
A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
A host organelle integrates stolen chloroplasts for animal photosynthesis
Sea slugs steal foreign chloroplasts and store them in specialized organelles that
facilitate photosynthesis and eventual digestion to mediate starvation resistance.
www.cell.com
September 17, 2025 at 5:04 PM
www.cell.com/cell/abstrac...
A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
A host organelle (in sea slugs) integrates stolen chloroplasts for animal photosynthesis
Reposted by David Vilchez
🧓Wie das Altern neurodegenerative Krankheiten treibt 🧠
@thevilchezlab.bsky.social @cecad.bsky.social hat einen direkten molekularen Zusammenhang zwischen Altern und neurodegenerativen Krankheiten identifiziert.
@thevilchezlab.bsky.social @cecad.bsky.social hat einen direkten molekularen Zusammenhang zwischen Altern und neurodegenerativen Krankheiten identifiziert.
September 3, 2025 at 3:17 PM
🧓Wie das Altern neurodegenerative Krankheiten treibt 🧠
@thevilchezlab.bsky.social @cecad.bsky.social hat einen direkten molekularen Zusammenhang zwischen Altern und neurodegenerativen Krankheiten identifiziert.
@thevilchezlab.bsky.social @cecad.bsky.social hat einen direkten molekularen Zusammenhang zwischen Altern und neurodegenerativen Krankheiten identifiziert.
Reposted by David Vilchez
🧓How aging drives neurodegenerative diseases🧠
@thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.
@thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.
September 3, 2025 at 3:24 PM
🧓How aging drives neurodegenerative diseases🧠
@thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.
@thevilchezlab.bsky.social @cecad.bsky.social has identified a direct molecular link between aging and neurodegeneration by investigating how age-related changes in cell signalling contribute to toxic protein aggregation.
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation - Nature Aging
Aging is a risk factor for neurodegenerative diseases associated with protein aggregation. Here the authors identify age-related hyperactivation of EPS8/RAC signaling in C. elegans as a driver of path...
www.nature.com
September 3, 2025 at 9:19 AM
🚨 New from our lab: Here we explored how aging contributes to harmful protein aggregation in diseases like Huntington’s & ALS.
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
The culprit? An overlooked aging factor — EPS8 and RAC signaling. #Aging #Longevity #Proteostasis #ALSResearch
🧵
www.nature.com/articles/s43...
New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...
FEBS Press
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient-derived neurons and C. elegans models, w...
febs.onlinelibrary.wiley.com
September 2, 2025 at 7:11 AM
New work from the lab! C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules - Bilican - FEBS Letters - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1002/...
Shuttle and stabilize: H1.2-FUS complex in amyotrophic lateral sclerosis pathogenesis
journals.lww.com/nrronline/ci...
journals.lww.com/nrronline/ci...
Shuttle and stabilize: H1.2-FUS complex in amyotrophic... : Neural Regeneration Research
An abstract is unavailable. This article is available as a PDF only.
journals.lww.com
August 30, 2025 at 6:27 AM
Shuttle and stabilize: H1.2-FUS complex in amyotrophic lateral sclerosis pathogenesis
journals.lww.com/nrronline/ci...
journals.lww.com/nrronline/ci...
Reposted by David Vilchez
💫NEW: @annaleder.bsky.social et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins. @masgu.bsky.social @hillerlab.bsky.social
bit.ly/47b3Mjk
bit.ly/47b3Mjk
A multichaperone condensate enhances protein folding in the endoplasmic reticulum - Nature Cell Biology
Leder et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins.
bit.ly
August 22, 2025 at 5:36 PM
💫NEW: @annaleder.bsky.social et al. show that the chaperones PDIA6, Hsp70 BiP, ERdj3, PDIA1 and Hsp90 form co-condensates within the endoplasmic reticulum, enhancing folding and preventing misfolding of client proteins. @masgu.bsky.social @hillerlab.bsky.social
bit.ly/47b3Mjk
bit.ly/47b3Mjk
Franziska Hommen did an excellent job in her thesis defense — we have a new PhD in the building! @cecad.bsky.social @cga-age.bsky.social
July 30, 2025 at 1:27 PM
Franziska Hommen did an excellent job in her thesis defense — we have a new PhD in the building! @cecad.bsky.social @cga-age.bsky.social
May 17, 2025 at 10:16 AM
We have a 4-year postdoc position open in our Research Unit on proteostasis!
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...
Postdoc Position (f/m/x)
We are looking to support our rapidly growing team as soon as possible:
jobs-uk-koeln.onlyfy.jobs
May 15, 2025 at 10:01 AM
We have a 4-year postdoc position open in our Research Unit on proteostasis!
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...
The project explores inter-tissue regulation using advanced proteomics approaches.
Collaborative & interdisciplinary environment. More details & application here:
jobs-uk-koeln.onlyfy.jobs/job/pktg6ivj...
Reposted by David Vilchez
🧪#Celegans - I am very excited to announce the publication of our latest finding in transgenerational epigenetic inheritance (TEI) of learned pathogen avoidance - • C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1 www.science.org/doi/10.1126/...
C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1
C. elegans’ TEI of learned pathogen avoidance is induced by a third bacterial small RNA, Pfs1, from P. fluorescens 15.
www.science.org
April 23, 2025 at 8:31 PM
🧪#Celegans - I am very excited to announce the publication of our latest finding in transgenerational epigenetic inheritance (TEI) of learned pathogen avoidance - • C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1 www.science.org/doi/10.1126/...
Reposted by David Vilchez
Online now - a tribute to the memory of Prof. Joan J. Guinovart from Jordi Duran and Matthew Gentry.
Prof. Guinovart was a renowned biochemist in the field of glycogen metabolism and known for his leadership in science.
(1/4)
Prof. Guinovart was a renowned biochemist in the field of glycogen metabolism and known for his leadership in science.
(1/4)
April 18, 2025 at 2:10 PM
Online now - a tribute to the memory of Prof. Joan J. Guinovart from Jordi Duran and Matthew Gentry.
Prof. Guinovart was a renowned biochemist in the field of glycogen metabolism and known for his leadership in science.
(1/4)
Prof. Guinovart was a renowned biochemist in the field of glycogen metabolism and known for his leadership in science.
(1/4)
New work from our lab;)
C9orf72 ALS-causing mutations lead to nucleoporin Nup107 aggregation and subsequent pathological changes https://www.biorxiv.org/content/10.1101/2025.04.16.649118v1
April 18, 2025 at 10:22 AM
New work from our lab;)
Thrilled to announce that our DFG Research Unit on cell-autonomous regulation of proteostasis has been approved for funding!
March 31, 2025 at 1:39 PM
Thrilled to announce that our DFG Research Unit on cell-autonomous regulation of proteostasis has been approved for funding!
Reposted by David Vilchez
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
March 3, 2025 at 3:55 PM
Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.
Reposted by David Vilchez
#NCB2024
In October, @toettch.bsky.social, McNamara & co reported that, in #gastruloids, cell sorting rearranges patchy domains of Wnt activity into a single pole, which defines the anterior–posterior axis.
rdcu.be/d4vk5
www.nature.com/articles/s41...
In October, @toettch.bsky.social, McNamara & co reported that, in #gastruloids, cell sorting rearranges patchy domains of Wnt activity into a single pole, which defines the anterior–posterior axis.
rdcu.be/d4vk5
www.nature.com/articles/s41...
Recording morphogen signals reveals mechanisms underlying gastruloid symmetry breaking
Nature Cell Biology - Toettcher, McNamara and colleagues use synthetic ‘signal-recording’ gene circuits on mouse gastruloids and find that cell sorting rearranges patchy domains of Wnt...
rdcu.be
December 22, 2024 at 9:30 PM
#NCB2024
In October, @toettch.bsky.social, McNamara & co reported that, in #gastruloids, cell sorting rearranges patchy domains of Wnt activity into a single pole, which defines the anterior–posterior axis.
rdcu.be/d4vk5
www.nature.com/articles/s41...
In October, @toettch.bsky.social, McNamara & co reported that, in #gastruloids, cell sorting rearranges patchy domains of Wnt activity into a single pole, which defines the anterior–posterior axis.
rdcu.be/d4vk5
www.nature.com/articles/s41...
I have no words to express how much I owe to Joan for his mentorship and advice. I became a professor thanks to his unwavering support. For instance, he insisted that I take English courses—and even paid for them—because I didn’t speak English while pursuing my PhD. I will miss you tons 😢😢
With great sadness, we announce the passing of Dr. Joan Guinovart, founder, former scientist, director, and Emeritus Professor of IRB Barcelona.
Our deepest condolences to his loved ones and the IRB Barcelona community.
You will always be remembered, Captain.
Our deepest condolences to his loved ones and the IRB Barcelona community.
You will always be remembered, Captain.
January 1, 2025 at 2:34 PM
I have no words to express how much I owe to Joan for his mentorship and advice. I became a professor thanks to his unwavering support. For instance, he insisted that I take English courses—and even paid for them—because I didn’t speak English while pursuing my PhD. I will miss you tons 😢😢
Reposted by David Vilchez
Here is a brief summary of academic journals and news account.
Please help me add more accounts to this list!
go.bsky.app/hCfhqn
Please help me add more accounts to this list!
go.bsky.app/hCfhqn
November 30, 2024 at 3:21 AM
Here is a brief summary of academic journals and news account.
Please help me add more accounts to this list!
go.bsky.app/hCfhqn
Please help me add more accounts to this list!
go.bsky.app/hCfhqn
If your are having issues receiving strains from the CGC in Europe, this can really help,…Launch of the European Hub for CGC strain distribution community.alliancegenome.org/t/european-s...
European Shipping Hub
We are glad to announce the launch of the European Hub for CGC strain distribution. Since the pandemic, CGC shipments have become increasingly difficult to manage with higher costs, longer transit ti...
community.alliancegenome.org
November 20, 2024 at 10:14 PM
If your are having issues receiving strains from the CGC in Europe, this can really help,…Launch of the European Hub for CGC strain distribution community.alliancegenome.org/t/european-s...
Reposted by David Vilchez
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
Action Intent Links | Bluesky
Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...
docs.bsky.app
November 18, 2024 at 2:48 PM
We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
docs.bsky.app/docs/advance...
#AcademicSky #HigherEd #Altmetrics
Bioart: a cool freeware alternative to Biorender bioart.niaid.nih.gov from the NIH
Bioart
bioart.niaid.nih.gov
November 18, 2024 at 6:40 AM
Bioart: a cool freeware alternative to Biorender bioart.niaid.nih.gov from the NIH
New paper from the lab! ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes: cell.com/cell-reports... #ALS
ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes
Alirzayeva et al. find that ALS-related mutant FUS gains interaction with PARP1 and
histone H1.2. Reducing either PARP1 activity or H1.2 levels prevents pathological
changes in human motor neurons and...
cell.com
August 21, 2024 at 3:37 PM
New paper from the lab! ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes: cell.com/cell-reports... #ALS