Theo Sanderson
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theo.io
Theo Sanderson
@theo.io
researching viral pathogen genomics at @lshtm.bsky.social | theo.io / sandersonlab.org
Reposted by Theo Sanderson
I want to spell this out in case the implications aren't clear:

This means all public tools/webapps of GISAID data (all the ones you've been used to seeing thru the pandemic, as far as we can tell) are prohibited.

The file allowed this. Cut that - cut off all tools the public & others were using.
On Oct 1, 2025, GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5
November 7, 2025 at 2:41 PM
Reposted by Theo Sanderson
Nextstrain's daily-updated tree of SARS-CoV-2 genomes was my gateway into the world of viral phylogenetics in early 2020, and Nextstrain's beautiful interactive tree display is crucial to making usher.bio results usable. GISAID cutting off data harms global surveillance efforts. 🧵👇
On Oct 1, 2025, GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5
November 7, 2025 at 5:03 AM
Reposted by Theo Sanderson
If you are looking for a PhD in the UK, please check out the LIDo program - www.lido-dtp.ac.uk/apply.
If you are interested in viruses and making genetically edited salmon, please look up my icase project.
International students are welcome to apply!
Please reach out if you have questions.
November 4, 2025 at 11:14 AM
Reposted by Theo Sanderson
Closing these public analyses puts the world more in the dark and concretely harms surveillance as it becomes more difficult for variant spotters to contribute to global situational awareness. 4/5
November 6, 2025 at 9:46 PM
Reposted by Theo Sanderson
On Oct 1, 2025, GISAID informed us that they had ended updates to the flat file of SARS-CoV-2 genomic sequences and associated metadata that we had used to update Nextstrain analyses since Feb 2020. GISAID's stated rationale was that their "resources are limited". 1/5
November 6, 2025 at 9:46 PM
GISAID on providing data to @Nextstrain.org: "After consulting with our staff and advisors on the feasibility of keeping your global tree up-to-date, there was a clear consensus that continuing to generate, zip and move big files back and forth is not sustainable and a waste of resources."
🙃
Nextstrain: Interruption to GISAID-based SARS-CoV-2 sequence analyses
Nextstrain blog post from 2025-11-06; author(s): Trevor Bedford, Richard Neher and the Nextstrain team
next.nextstrain.org
November 6, 2025 at 9:51 PM
Reposted by Theo Sanderson
@andersonfbrito.bsky.social and I are seeking input from the community on hosting/sharing arbovirus sequencing data (DENV, CHIKV, OROV, ZIKV, & YFV) on @pathoplexus.org.

Please consider filling out this VERY SHORT survey about your interest and/or concerns.

docs.google.com/forms/d/e/1F...
Community survey on the addition of Dengue, Chikungunya, Oropouche, Zika and Yellow fever virus to Pathoplexus
Pathoplexus is a new platform for sharing pathogen sequence data, launched in August 2024 [1], with the primary aim of making sharing and accessing pathogen genomic data easier, faster, and more effic...
docs.google.com
October 30, 2025 at 8:11 PM
Reposted by Theo Sanderson
How certain is certain enough? This is probably the last public London talk I'll be giving on Proof in 2025 – and it's free – so see you there at 5.30pm on 24th November if you're around!

www.lshtm.ac.uk/newsevents/e...
How certain is certain enough? | LSHTM
When faced with a new health threat, there are three crucial questions we must consider. What is going on? What can we do about it? And how can we communicate these things effectively? This talk will
www.lshtm.ac.uk
October 24, 2025 at 6:28 PM
Reposted by Theo Sanderson
Tune in to find out:

- how to go from hallucinated cat pictures to hallucinated proteins
- whether @jacobtref.bsky.social can do photosynthesis
- whether we can make tiny protein straws for tardigrades to drink from
New episode of Hard Drugs!

What if you could design a protein never seen in nature?

Scientists are using new AI tools like RFDiffusion, AlphaFold & ProteinMPNN to hallucinate novel proteins to solve problems nature hasn't.

@jacobtref.bsky.social & I talk about the art of protein design 🧑‍🎨
The art of protein design with AI
YouTube video by Works in Progress
www.youtube.com
October 17, 2025 at 10:30 PM
Reposted by Theo Sanderson
I built a free tool to try to embarrass British police into doing their job cctv.numpad.io. More info here: onodi.co/bisect/
October 17, 2025 at 10:19 AM
The first mostly-AI-rendered film to gross >$100m worldwide will be released in

1️⃣ <a href="https://poll.blue/p/BxInEF/1" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">2026-2027
2️⃣ <a href="https://poll.blue/p/BxInEF/2" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">2028-2029
3️⃣ <a href="https://poll.blue/p/BxInEF/3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">2030-2035
4️⃣ <a href="https://poll.blue/p/BxInEF/4" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">2036+

📊 Show results
October 10, 2025 at 12:10 AM
Reposted by Theo Sanderson
The Mercator projection if it weren’t cropped

(click to view full size)
October 9, 2025 at 4:10 PM
Reposted by Theo Sanderson
#UKHSAVirusWatch is back, a summary of our weekly winter surveillance report .🦠🧵
This week's data shows an increase in COVID-19 activity, which is circulating at medium levels. Flu activity has also increased, particularly in those aged 15 to 24, but remains at baseline levels.
October 9, 2025 at 3:18 PM
Reposted by Theo Sanderson
“The Ebola virus disease (EVD) outbreak in the Democratic Republic of the Congo (DRC) shows signs of containment, with no new confirmed or probable cases reported since our last update”
Some cautious good news from @who.int
#IDSky

hq_who_departmentofcommunications.cmail19.com/t/d-l-ggllll...
October 8, 2025 at 5:25 PM
seems like we'll still have a job for a year or two #sora
October 7, 2025 at 9:42 PM
this is real fiasco
GPT5 switches to hidden output in its chain of thought:

‘However illusions: In Redwood Redwood "embedding ".

D …………………….’
October 7, 2025 at 9:20 PM
🤫
October 7, 2025 at 8:38 PM
Reposted by Theo Sanderson
Do you guys remember when they created a neuron-level model of a fruit fly’s brain and they made it sense something sweet and it stuck out its tongue
September 6, 2025 at 4:26 AM
enjoyed the bento lab in one battle after another
October 5, 2025 at 3:52 PM
(not intended as serious analysis!)
October 3, 2025 at 6:52 PM
Reposted by Theo Sanderson
No, you are not our product. Our product _is_ the code that we write and distribute for others to use. For others to take and build their communities. Making the users the product is exactly the model that never works and continues to never work.
October 3, 2025 at 2:25 PM
Reposted by Theo Sanderson
Amazing breakfast this morning. I love waffles
October 2, 2025 at 6:36 PM
In 2030 what proportion of the video content the average American watches will be directly AI-generated? (normalised by watch-time)

1️⃣ <a href="https://poll.blue/p/XKyvHx/1" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky"><10%
2️⃣ <a href="https://poll.blue/p/XKyvHx/2" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">10-30%
3️⃣ <a href="https://poll.blue/p/XKyvHx/3" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">30%-60%
4️⃣ <a href="https://poll.blue/p/XKyvHx/4" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link" target="_blank" rel="noopener" data-link="bsky">>60%

📊 Show results
October 1, 2025 at 9:50 PM