Karen Maxwell
@themaxwelllab.bsky.social
Phage biologist focused on virus-host interactions and bacterial pathogenesis.
Reposted by Karen Maxwell
Excited to share: DNA glycosylases are diverse antiviral effectors. They recognize phage base modifications and initiate genome destruction. A structure‑guided approach made the scope of this discovery possible! 🧪 #phagesky doi.org/10.1101/2025... #phage #microbiology
Antiviral Defence is a Conserved Function of Diverse DNA Glycosylases
Bacteria are frequently attacked by viruses, known as phages, and rely on diverse defence systems like restriction endonucleases and CRISPR-Cas to survive. While phages can evade these defences by cov...
doi.org
October 30, 2025 at 12:16 PM
Excited to share: DNA glycosylases are diverse antiviral effectors. They recognize phage base modifications and initiate genome destruction. A structure‑guided approach made the scope of this discovery possible! 🧪 #phagesky doi.org/10.1101/2025... #phage #microbiology
Reposted by Karen Maxwell
It’s out! Brand new work from my PostDoc in @themaxwelllab.bsky.social exploring anti-phage defence in V. parahaemolyticus: Integrons are anti-phage defence libraries in Vibrio parahaemolyticus
rdcu.be/d7EsN
rdcu.be/d7EsN
Integrons are anti-phage defence libraries in Vibrio parahaemolyticus
Nature Microbiology - Integrons are genetic elements that capture and store gene cassettes in Vibrio species. Bioinformatic and molecular techniques show that these regions can be hotspots of phage...
rdcu.be
January 27, 2025 at 3:48 PM
It’s out! Brand new work from my PostDoc in @themaxwelllab.bsky.social exploring anti-phage defence in V. parahaemolyticus: Integrons are anti-phage defence libraries in Vibrio parahaemolyticus
rdcu.be/d7EsN
rdcu.be/d7EsN
This study led by @landongetz.bsky.social shows that anti-phage defences are stored in Vibrio integrons. It was so much fun to work with Landon and his team on this exciting project!
OUT NOW: Integrons are anti-phage defence libraries in Vibrio parahaemolyticus
@themaxwelllab.bsky.social
www.nature.com/articles/s41...
@themaxwelllab.bsky.social
www.nature.com/articles/s41...
Integrons are anti-phage defence libraries in Vibrio parahaemolyticus - Nature Microbiology
Integrons are genetic elements that capture and store gene cassettes in Vibrio species. Bioinformatic and molecular techniques show that these regions can be hotspots of phage defence systems.
www.nature.com
January 27, 2025 at 4:14 PM
This study led by @landongetz.bsky.social shows that anti-phage defences are stored in Vibrio integrons. It was so much fun to work with Landon and his team on this exciting project!